Edward G. Lakatta

TL;DR: It is concluded that the widely divergent, Ca2+-dependent systolic and diastolic properties of intact rat and rabbit cardiac muscle are retained with a high degree of fidelity in the majority of viable single myocytes isolated from the myocardium of these species, and that these myocytes are thus a valid model for studies of Ca2-dependent excitation- contraction mechanisms in the heart.

TL;DR: Manipulating the cardiac Mito membrane n-3-to-n-6 PUFA ratio shows that the activation of Ca2+-dependent PDH can be augmented when the n-4 to n-6PUFA ratio is low, or attenuated when this ratio is relatively high (n-3 PUFA-rich diet).

TL;DR: Ca2+ release flux across the sarcoplasmic reticulum (SR) during cardiac excitation‐contraction coupling was investigated using a novel fluorescence method and it appears that not only the amount of Ca2+ released, but also the synchronization among release sites affects the whole‐cell Ca2- transient and the Ca2‐‐myofilament interaction.

TL;DR: It is concluded that discordant regulation of factors that determine the activation status of type 2 matrix metalloprotease, coupled with an increase in the expression of its zymogen, occur with aging, which lead to an increased in the amount of activated protease.

TL;DR: It is proposed that the action of EMD 57033 is at the actin-myosin interface on a "receptor" that may be on actin or the crossbridge of crossbridges from weak to strong force-generating states.