Edward G. Lakatta

TL;DR: Rest and exercise left ventricular function are not related to percent body fat in healthy older men, however, older more obese men have a smaller increase in heart rate and end diastolic volume and a greater decrease in end systolic volumefrom rest to peak effort as a mechanism to augment exercise cardiac output.

TL;DR: In this article, the authors show that Ca2+ and Vm domain kinetic transitions (time to AP ignition in diastole and 90% AP recovery) occurring within given AP, the mean AP firing intervals, and AP firing interval variabilities within time-series of APs in 230 individual nodal cells are self-similar (obey power laws).

TL;DR: Intrinsic cycle length variability in single SANC is linked to cycle to cycle stochastic variations in roughly periodic LCRs, and closely predicted the time of occurrence of the next AP.

TL;DR: A review of the field of cardiac-aging research across the spectrum of change with a special focus on discoveries at the microscopic level is provided.

TL;DR: This article will review, and provide a synthesis, of the most recent findings on the wide range of actions of NO on myocardial contractility in an attempt to discriminate the downstream effectors, and to establish whether the multiple contractile responses to NO may be attributed to the activation of distinct cGMP- dependent or independent mechanisms.