E
Edward G. Lakatta
Researcher at National Institutes of Health
Publications - 902
Citations - 95504
Edward G. Lakatta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 146, co-authored 858 publications receiving 88637 citations. Previous affiliations of Edward G. Lakatta include University of Pittsburgh & University College London.
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Journal Article
Leucine-enkephalin increases the level of inositol (1,4,5) triphosphate and releases calcium from an intracellular pool in rat ventricular cardiac myocytes.
TL;DR: Leu-Enk induces depletion of Ca2+ from the SR by a receptor-mediated mechanism which appears to involve an increase in the intracellular level of Ins (1,4,5) P3.
Journal ArticleDOI
Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats
Vladimir A. Kashkin,Edwin Zvartau,Olga V. Fedorova,Yakov Y. Bagrov,Edward G. Lakatta,Alexei Y. Bagrov +5 more
TL;DR: In vivo administration of anti-MBG antibody to rats prevented withdrawal-induced BP elevation, and may link mechanisms of ethanol dependence and hypertension.
Posted ContentDOI
Genetic analysis of over one million people identifies 535 novel loci for blood pressure
Evangelos Evangelou,Evangelos Evangelou,Helen R. Warren,Helen R. Warren,David Mosen-Ansorena,Borbala Mifsud,Raha Pazoki,He Gao,Georgios Ntritsos,Niki Dimou,Claudia P. Cabrera,Claudia P. Cabrera,Ibrahim Karaman,Fu Liang Ng,Marina Evangelou,K. Witkowska,Evan Tzanis,Jacklyn N. Hellwege,Ayush Giri,Digna R. Velez Edwards,Yan V. Sun,Kelly Cho,Kelly Cho,J. Michael Gaziano,J. Michael Gaziano,Peter W.F. Wilson,Philip S. Tsao,Csaba P. Kovesdy,Tõnu Esko,Tõnu Esko,Reedik Mägi,Lili Milani,Peter Almgren,Thibaud Boutin,Stéphanie Debette,Jun Ding,Franco Giulianini,Elizabeth G. Holliday,Anne U. Jackson,Ruifang Li-Gao,Wei-Yu Lin,Jian'an Luan,Massimo Mangino,Christopher Oldmeadow,Bram P. Prins,Yong Qian,Muralidharan Sargurupremraj,Nabi Shah,Nabi Shah,Praveen Surendran,Sébastien Thériault,Sébastien Thériault,Niek Verweij,Niek Verweij,Sara M. Willems,Jing Hua Zhao,Philippe Amouyel,John M. C. Connell,Renée de Mutsert,Alex S. F. Doney,Martin Farrall,Martin Farrall,Cristina Menni,Andrew D. Morris,Raymond Noordam,Guillaume Paré,Neil Poulter,Denis C. Shields,Alice Stanton,Simon Thom,Gonçalo R. Abecasis,Najaf Amin,Dan E. Arking,Kristin L. Ayers,Caterina Barbieri,Chiara Batini,Joshua C. Bis,Tineka Blake,Murielle Bochud,Michael Boehnke,Eric Boerwinkle,Dorret I. Boomsma,Erwin P. Bottinger,Peter S. Braund,Marco Brumat,Archie Campbell,Harry Campbell,Aravinda Chakravarti,John C. Chambers,Ganesh Chauhan,Marina Ciullo,Massimiliano Cocca,Francis S. Collins,Heather J. Cordell,Gail Davies,Martin H. de Borst,Eco J. C. de Geus,Ian J. Deary,Joris Deelen,Fabiola M Del Greco,Cumhur Y Demirkale,Marcus Dörr,Georg Ehret,Georg Ehret,Roberto Elosua,Stefan Enroth,A. Mesut Erzurumluoglu,Teresa Ferreira,Mattias Frånberg,Mattias Frånberg,Oscar H. Franco,Ilaria Gandin,Paolo Gasparini,Vilmantas Giedraitis,Christian Gieger,Giorgia Girotto,Anuj Goel,Anuj Goel,Alan J. Gow,Alan J. Gow,Vilmundur Gudnason,Xiuqing Guo,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Sarah E. Harris,Catharina A. Hartman,Aki S. Havulinna,Andrew A. Hicks,Edith Hofer,Albert Hofman,Jouke-Jan Hottenga,Jennifer E. Huffman,Shih-Jen Hwang,Erik Ingelsson,Erik Ingelsson,Alan L. James,Rick Jansen,Marjo-Riitta Järvelin,Roby Joehanes,Åsa Johansson,Andrew D. Johnson,Peter K. Joshi,Pekka Jousilahti,J. Wouter Jukema,Antti Jula,Mika Kähönen,Sekar Kathiresan,Sekar Kathiresan,Bernard Keavney,Bernard Keavney,Kay-Tee Khaw,Paul Knekt,Joanne Knight,Ivana Kolcic,Jaspal S. Kooner,Seppo Koskinen,Kati Kristiansson,Zoltán Kutalik,Zoltán Kutalik,Maris Laan,Marty Larson,Lenore J. Launer,Benjamin Lehne,Terho Lehtimäki,Daniel Levy,David C. Liewald,Li Lin,Lars Lind,Cecilia M. Lindgren,Cecilia M. Lindgren,Yongmei Liu,Ruth J. F. Loos,Ruth J. F. Loos,Lorna M. Lopez,Lorna M. Lopez,Lorna M. Lopez,Lingchan Lu,Leo-Pekka Lyytikäinen,Anubha Mahajan,Chrysovalanto Mamasoula,Jaume Marrugat,Jonathan Marten,Yuri Milaneschi,Anna Morgan,Andrew P. Morris,Andrew P. Morris,Alanna C. Morrison,Peter J. Munson,Mike A. Nalls,Priyanka Nandakumar,Christopher P. Nelson,Christopher Newton-Cheh,Teemu J. Niiranen,Ilja M. Nolte,Teresa Nutile,Albertine J. Oldehinkel,Ben A. Oostra,Paul F. O'Reilly,Elin Org,Sandosh Padmanabhan,Sandosh Padmanabhan,Walter Palmas,Arno Palotie,Alison Pattie,Brenda W.J.H. Penninx,Markus Perola,Markus Perola,Markus Perola,Annette Peters,Ozren Polasek,Peter P. Pramstaller,Nguyen Quang Tri,Olli T. Raitakari,Olli T. Raitakari,Meixia Ren,Meixia Ren,Rainer Rettig,Kenneth Rice,Paul M. Ridker,Janina S Reid,Harriëtte Riese,Samuli Ripatti,Antonietta Robino,Lynda M. Rose,Jerome I. Rotter,Igor Rudan,Daniella Ruggiero,Yasaman Saba,Cinzia Sala,Veikko Salomaa,Nilesh J. Samani,Antti-Pekka Sarin,Rheinhold Schmidt,Helena Schmidt,Nick Shrine,David S. Siscovick,Albert V. Smith,Harold Schneider,Siim Sõber,Rossella Sorice,John M. Starr,David J. Stott,David P. Strachan,Rona J. Strawbridge,Johan Sundström,Morris A. Swertz,Kent D. Taylor,Alexander Teumer,Martin D. Tobin,Daniela Toniolo,Michela Traglia,Stella Trompet,Jaakko Tuomilehto,Christophe Tzourio,André G. Uitterlinden,Ahmad Vaez,Ahmad Vaez,Peter J. van der Most,Cornelia M. van Duijn,Anne-Claire Vergnaud,Germaine C. Verwoert,Veronique Vitart,Uwe Völker,Peter Vollenweider,Dragana Vuckovic,Hugh Watkins,Hugh Watkins,Sarah H. Wild,Gonneke Willemsen,James F. Wilson,Alan F. Wright,Jie Yao,Tatijana Zemunik,Weihua Zhang,John Attia,Adam S. Butterworth,Adam S. Butterworth,Daniel I. Chasman,David Conen,Francesco Cucca,John Danesh,John Danesh,Caroline Hayward,Joanna M. M. Howson,Markku Laakso,Edward G. Lakatta,Claudia Langenberg,Ollie Melander,Dennis O. Mook-Kanamori,Patricia B. Munroe,Colin N. A. Palmer,Lorenz Risch,Robert A. Scott,Rodney J. Scott,Peter S. Sever,Tim D. Spector,Pim van der Harst,Nicholas J. Wareham,Eleftheria Zeggini,Morris Brown,Morris Brown,Andres Metspalu,Adriana M. Hung,Christopher J. O'Donnell,Todd L. Edwards,Bruce M. Psaty,Bruce M. Psaty,Ioanna Tzoulaki,Ioanna Tzoulaki,Michael R. Barnes,Michael R. Barnes,Louise V. Wain,Paul Elliott,Mark J. Caulfield,Mark J. Caulfield +315 more
TL;DR: This work identifies 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also reveal shared loci influencing lifestyle exposures that offer the potential for a precision medicine strategy for future cardiovascular disease prevention.
Journal ArticleDOI
Contribution of spontaneous L-type Ca2+ channel activation to the genesis of Ca2+ sparks in resting cardiac myocytes.
Zhang Guangqin,Fu Yu,Yang Dongmei,Hao Xuemei,Bai Shuhua,Tang Yiqun,Edward G. Lakatta,Wu Caihong,Cheng He-ping +8 more
TL;DR: In this paper, the authors used confocal laser scanning microscopy and fluo-4 to visualize local Ca2+ sparks in intact rat ventricular myocytes and found that infrequent and stochastic openings of sarcolemmal L-type channels in resting heart cells contribute significantly to the production of spontaneous Ca 2+ sparks.
Journal ArticleDOI
Age Associated Decrease in Intrinsic Action Potential (AP) Firing Rate in Sinoatrial Node Cells is Linked to Deficient Intrinsic cAMP-PKA-Ca2+ Signaling
TL;DR: It is concluded that intrinsic SR Ca2+cycling and its response to PDE inhibition decline with age, and that this decline is linked to the age-associated decrease in IAPFR.