G
George Davey Smith
Researcher at University of Bristol
Publications - 2646
Citations - 294406
George Davey Smith is an academic researcher from University of Bristol. The author has contributed to research in topics: Population & Mendelian randomization. The author has an hindex of 224, co-authored 2540 publications receiving 248373 citations. Previous affiliations of George Davey Smith include Keele University & Western Infirmary.
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Journal ArticleDOI
Recent Developments in Mendelian Randomization Studies
Jie Zheng,Denis Baird,Maria Carolina Borges,Jack Bowden,Gibran Hemani,Philip C Haycock,David M. Evans,David M. Evans,George Davey Smith +8 more
TL;DR: In conjunction with the growing availability of large-scale genomic databases, higher level of automation and increased robustness of the methods, MR promises to be a valuable strategy to examine causality in complex biological/omics networks, inform drug development and prioritize intervention targets for disease prevention in the future.
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Cholesterol lowering and mortality: the importance of considering initial level of risk.
TL;DR: Currently evaluated cholesterol lowering drugs seem to produce mortality benefits in only a small proportion of patients at very high risk of death from coronary heart disease, and future trials should aim to clarify the level of risk above which treatment is of net benefit.
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Reduced or modified dietary fat for preventing cardiovascular disease
Lee Hooper,Carolyn Summerbell,Rachel Thompson,Deirdre Sills,Felicia G. Roberts,Helen J Moore,George Davey Smith +6 more
TL;DR: The findings are suggestive of a small but potentially important reduction in cardiovascular risk on modification of dietary fat, but not reduction of total fat, in longer trials.
Journal ArticleDOI
Mendelian randomization in cardiometabolic disease: challenges in evaluating causality
TL;DR: Challenges in interpreting Mendelian randomization analyses are described, including those from studies using genetic variants to assess causality of multiple traits; studies describing pleiotropic variants; and those investigating variants that disrupt normal function of an exposure.
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Objectively Measured Physical Activity and Fat Mass in a Large Cohort of Children
Andy R Ness,Sam D Leary,Calum Mattocks,Steven N. Blair,John J. Reilly,Jonathan C. K. Wells,Sue Ingle,Kate Tilling,George Davey Smith,Chris Riddoch +9 more
TL;DR: A strong graded inverse association between physical activity and obesity that was stronger in boys is demonstrated and the data suggest that higher intensity physical activity may be more important than total activity.