G
George Davey Smith
Researcher at University of Bristol
Publications - 2646
Citations - 294406
George Davey Smith is an academic researcher from University of Bristol. The author has contributed to research in topics: Population & Mendelian randomization. The author has an hindex of 224, co-authored 2540 publications receiving 248373 citations. Previous affiliations of George Davey Smith include Keele University & Western Infirmary.
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Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits
Ioanna Tachmazidou,Daniel Suveges,Josine L. Min,Graham R. S. Ritchie,Graham R. S. Ritchie,Julia Steinberg,Klaudia Walter,Valentina Iotchkova,Valentina Iotchkova,Jeremy Schwartzentruber,Jie Huang,Yasin Memari,Shane A. McCarthy,Andrew A Crawford,Cristina Bombieri,Massimiliano Cocca,Aliki-Eleni Farmaki,Tom R. Gaunt,Pekka Jousilahti,Marjolein N. Kooijman,Benjamin Lehne,Giovanni Malerba,Satu Männistö,Angela Matchan,Carolina Medina-Gomez,Sarah Metrustry,Abhishek Nag,Ioanna Ntalla,Lavinia Paternoster,Nigel W. Rayner,Nigel W. Rayner,Nigel W. Rayner,Cinzia Sala,William R. Scott,William R. Scott,Hashem A. Shihab,Lorraine Southam,Lorraine Southam,Beate St Pourcain,Michela Traglia,Katerina Trajanoska,Gialuigi Zaza,Weihua Zhang,Weihua Zhang,María Soler Artigas,Narinder Bansal,Marianne Benn,Marianne Benn,Zhongsheng Chen,Petr Danecek,Petr Danecek,Wei-Yu Lin,Adam E. Locke,Adam E. Locke,Jian'an Luan,Alisa K. Manning,Alisa K. Manning,Antonella Mulas,Carlo Sidore,Anne Tybjærg-Hansen,Anne Tybjærg-Hansen,Anette Varbo,Anette Varbo,Magdalena Zoledziewska,Chris Finan,Konstantinos Hatzikotoulas,Audrey E. Hendricks,Audrey E. Hendricks,John P. Kemp,Alireza Moayyeri,Alireza Moayyeri,Kalliope Panoutsopoulou,Michal Szpak,Scott Wilson,Scott Wilson,Scott Wilson,Michael Boehnke,Francesco Cucca,Emanuele Di Angelantonio,Emanuele Di Angelantonio,Claudia Langenberg,Cecilia M. Lindgren,Cecilia M. Lindgren,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Børge G. Nordestgaard,Børge G. Nordestgaard,Robert A. Scott,Martin D. Tobin,Martin D. Tobin,Nicholas J. Wareham,Paul Burton,John C. Chambers,John C. Chambers,John C. Chambers,George Davey Smith,George Dedoussis,Janine F. Felix,Oscar H. Franco,Giovanni Gambaro,Paolo Gasparini,Christopher J Hammond,Albert Hofman,Vincent W. V. Jaddoe,Marcus E. Kleber,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Markus Perola,Markus Perola,Markus Perola,Caroline L Relton,Susan M. Ring,Fernando Rivadeneira,Veikko Salomaa,Tim D. Spector,Oliver Stegle,Daniela Toniolo,André G. Uitterlinden,Inês Barroso,Inês Barroso,Celia M. T. Greenwood,Celia M. T. Greenwood,John R. B. Perry,John R. B. Perry,Brian R. Walker,Adam S. Butterworth,Adam S. Butterworth,Yali Xue,Richard Durbin,Kerrin S. Small,Nicole Soranzo,Nicholas J. Timpson,Eleftheria Zeggini +137 more
TL;DR: This work applied a hybrid whole-genome sequencing (WGS) and deep imputation approach to examine the broader allelic architecture of 12 anthropometric traits associated with height, body mass, and fat distribution in up to 267,616 individuals to report 106 genome-wide significant signals that have not been previously identified.
Journal ArticleDOI
Longitudinal analysis of DNA methylation associated with birth weight and gestational age
Andrew J Simpkin,Matthew Suderman,Tom R. Gaunt,Oliver Lyttleton,Wendy L. McArdle,Susan M. Ring,Kate Tilling,George Davey Smith,Caroline L Relton +8 more
TL;DR: Analysis of serial methylation from birth to adolescence provided evidence for a lack of persistence of methylation differences beyond early childhood, and sites associated with birth weight were linked to developmental genes and have methylation levels which are associated with developmental phenotypes.
Journal ArticleDOI
Cardiovascular biomarkers and vascular function during childhood in the offspring of mothers with hypertensive disorders of pregnancy: findings from the Avon Longitudinal Study of Parents and Children
Debbie A Lawlor,Corrie Macdonald-Wallis,Abigail Fraser,Scott M. Nelson,Aroon D. Hingorani,George Davey Smith,Naveed Sattar,John E. Deanfield +7 more
TL;DR: The findings support the existence of shared mother-offspring risk factors that are specific for higher BP, rather than the additional cardiometabolic abnormalities of hypertensive disorder of pregnancy having long-term consequences for offspring.
Journal ArticleDOI
AHRR (cg05575921) hypomethylation marks smoking behaviour, morbidity and mortality
Stig E. Bojesen,Stig E. Bojesen,Nicholas J. Timpson,Caroline L Relton,George Davey Smith,Børge G. Nordestgaard,Børge G. Nordestgaard +6 more
TL;DR: AHRR (cg05575921) hypomethylation, a marker of smoking behaviour, provides potentially clinical relevant predictions of future smoking-related morbidity and mortality.
Journal ArticleDOI
Prepubertal start of father's smoking and increased body fat in his sons: further characterisation of paternal transgenerational responses
TL;DR: The results highlight the importance of the developmental timing of the paternal exposure as well as gender differences in offspring outcomes and smoking by boys in mid childhood may contribute to obesity in adolescent boys of the next generation.