G
George Davey Smith
Researcher at University of Bristol
Publications - 2646
Citations - 294406
George Davey Smith is an academic researcher from University of Bristol. The author has contributed to research in topics: Population & Mendelian randomization. The author has an hindex of 224, co-authored 2540 publications receiving 248373 citations. Previous affiliations of George Davey Smith include Keele University & Western Infirmary.
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Journal ArticleDOI
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus
Carolina Medina-Gomez,John P. Kemp,Karol Estrada,Joel Eriksson,Jeff Liu,Sjur Reppe,David M. Evans,Denise H.M. Heppe,Liesbeth Vandenput,Lizbeth Herrera,Susan M. Ring,Claudia J. Kruithof,Nicholas J. Timpson,M. Carola Zillikens,Ole Kristoffer Olstad,Hou-Feng Zheng,Hou-Feng Zheng,J. Brent Richards,J. Brent Richards,J. Brent Richards,Beate St Pourcain,Albert Hofman,Vincent W. V. Jaddoe,George Davey Smith,Mattias Lorentzon,Kaare M. Gautvik,André G. Uitterlinden,Robert Brommage,Claes Ohlsson,Jonathan H Tobias,Fernando Rivadeneira +30 more
TL;DR: Wnt16 knockout mice with reduced total body BMD and gene expression profiles in human bone biopsies support a role of C7orf58 and WNT16 on the BMD phenotypes observed at the human population level.
Journal ArticleDOI
IQ in Early Adulthood and Mortality By Middle Age Cohort Study of 1 Million Swedish Men
G. David Batty,Karin Modig Wennerstad,George Davey Smith,David Gunnell,Ian J. Deary,Per Tynelius,Finn Rasmussen +6 more
TL;DR: In this paper, a cohort of over 1 million Swedish men who underwent IQ testing at military service conscription at about 18 years of age was followed for mortality experience until middle age, and found a robust stepwise relation between early adult IQ and risk of total and accident mortality in men.
Journal ArticleDOI
DNA Methylation Patterns in Cord Blood DNA and Body Size in Childhood
Caroline L Relton,Alexandra Groom,Beate St Pourcain,Adrian Sayers,Daniel Swan,Nicholas D. Embleton,Nicholas D. Embleton,Mark S. Pearce,Susan M. Ring,Kate Northstone,Jon H Tobias,Joseph Trakalo,Andy R Ness,Seif O. Shaheen,George Davey Smith +14 more
TL;DR: DNA methylation patterns in cord blood show some association with altered gene expression, body size and composition in childhood, and despite suggestion of a mechanistic epigenetic link between in utero life and later phenotype, further investigation is required to establish causality.
Journal ArticleDOI
Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium
Amy E Taylor,Meg E Fluharty,Johan Håkon Bjørngaard,Maiken Elvestad Gabrielsen,Frank Skorpen,Riccardo E. Marioni,Archie Campbell,Jorgen Engmann,Saira Saeed Mirza,Anu Loukola,Tiina Laatikainen,Timo Partonen,Marika Kaakinen,Francesca Ducci,Alana Cavadino,Lise Lotte N. Husemoen,Tarunveer S. Ahluwalia,Rikke Kart Jacobsen,Tea Skaaby,Jeanette Frost Ebstrup,Erik Lykke Mortensen,Camelia C. Minică,Jacqueline M. Vink,Gonneke Willemsen,Pedro Marques-Vidal,Caroline Dale,Antoinette Amuzu,Lucy T. Lennon,Jari Lahti,Aarno Palotie,Katri Räikkönen,Andrew Wong,Lavinia Paternoster,Angelita Pui-Yee Wong,L. John Horwood,Michael F. Murphy,Elaine C. Johnstone,Martin A. Kennedy,Zdenka Pausova,Tomáš Paus,Yoav Ben-Shlomo,Ellen A. Nohr,Diana Kuh,Mika Kivimäki,Johan G. Eriksson,Richard W Morris,Juan P. Casas,Martin Preisig,Dorret I. Boomsma,Allan Linneberg,Chris Power,Elina Hyppönen,Juha Veijola,Marjo-Riitta Järvelin,Tellervo Korhonen,Henning Tiemeier,Meena Kumari,David J. Porteous,Caroline Hayward,Pål Richard Romundstad,George Davey Smith,Marcus R. Munafò +61 more
TL;DR: Findings from Mendelian randomisation analyses do not support a causal role of smoking heaviness in the development of depression and anxiety.
Journal ArticleDOI
BMI as a Modifiable Risk Factor for Type 2 Diabetes: Refining and Understanding Causal Estimates Using Mendelian Randomization.
Laura J Corbin,Rebecca C Richmond,Kaitlin H Wade,Stephen Burgess,Jack Bowden,George Davey Smith,Nicholas J. Timpson +6 more
TL;DR: The potential for pleiotropic genetic variants to generate bias, revise existing estimates, and illustrate value in new analysis methods are explored and the potential for new approaches to mitigate the bias caused is demonstrated.