George Davey Smith

TL;DR: Among Danish children, those with the most educated and highest earning parents had least insulin resistance, whereas the opposite was true for children from Estonia and Portugal.

TL;DR: Genetic inhibition of PCSK9 had similar metabolic effects to statin therapy on detailed lipid and metabolite profiles, however,PCSK9 inhibitors are predicted to have weaker effects on very-low-density lipoprotein lipids compared with statins for an equivalent lowering of low-densitylipoprotein cholesterol, which potentially translate into smaller reductions in cardiovascular disease risk.

TL;DR: Testing the association between obesity measured by body mass index (BMI) and one of the best-known genetic variants showing strong selective pressure: the functional variant in the cis-regulatory element of the lactase gene found that the carriers of the allele responsible for LP among Europeans showed higher BMI.

TL;DR: The lack of association between fat mass and a methylation proxy SNP suggests that reverse causation or confounding may explain the initial association betweenFat mass and gene regulation and noncausal methylation patterns may still be useful predictors of later adiposity.

TL;DR: The established association of rs1229984 with reduced alcohol consumption over the life-course is confirmed, contributing new evidence of an effect before and during pregnancy.