G
George Davey Smith
Researcher at University of Bristol
Publications - 2646
Citations - 294406
George Davey Smith is an academic researcher from University of Bristol. The author has contributed to research in topics: Population & Mendelian randomization. The author has an hindex of 224, co-authored 2540 publications receiving 248373 citations. Previous affiliations of George Davey Smith include Keele University & Western Infirmary.
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Separating the Mechanism-Based and Off-Target Actions of Cholesteryl Ester Transfer Protein Inhibitors With CETP Gene Polymorphisms
Reecha Sofat,Aroon D. Hingorani,Liam Smeeth,Steve E. Humphries,Philippa J. Talmud,Jackie A. Cooper,Tina Shah,Manjinder S. Sandhu,Sally L. Ricketts,S. Matthijs Boekholdt,S. Matthijs Boekholdt,Nicholas J. Wareham,Kay-Tee Khaw,Meena Kumari,Mika Kivimäki,Michael Marmot,Folkert W. Asselbergs,Pim van der Harst,Robin P. F. Dullaart,Gerjan Navis,Dirk J. van Veldhuisen,Wiek H. van Gilst,John F. Thompson,Pamela A. McCaskie,Lyle J. Palmer,Marcello Arca,Fabiana Quagliarini,Carlo Gaudio,François Cambien,Viviane Nicaud,Odette Poirer,Vilmundur Gudnason,Aaron Isaacs,Jacqueline C.M. Witteman,Cornelia M. van Duijn,Michael J. Pencina,Ramachandran S. Vasan,Ralph B. D'Agostino,Jose M. Ordovas,Tricia Li,Sakari Kakko,Heikki Kauma,Markku J. Savolainen,Y. Antero Kesäniemi,A. Sandhofer,Bernhard Paulweber,José V. Sorlí,Akimoto Goto,Shinji Yokoyama,Kenji Okumura,Benjamin D. Horne,Chris J. Packard,Dilys J. Freeman,Ian Ford,Naveed Sattar,Valerie McCormack,Debbie A Lawlor,Shah Ebrahim,George Davey Smith,John J.P. Kastelein,John E. Deanfield,Juan P. Casas,Juan P. Casas +62 more
TL;DR: In this paper, the effect of single-nucleotide polymorphisms and torcetrapib treatment on lipid fractions, blood pressure, and electrolytes in up to 67 687 individuals from genetic studies and 17 911 from randomized trials was compared.
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Modifiable Maternal Exposures and Offspring Blood Pressure: A Review of Epidemiological Studies of Maternal Age, Diet, and Smoking
TL;DR: In this paper, the authors reviewed epidemiology studies of modifiable maternal exposures and offspring blood pressure (BP) and found no strong evidence that any component of maternal diet during pregnancy (maternal protein, energy, calcium, and various other nutrients) influences offspring BP.
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Changes in ponderal index and body mass index across childhood and their associations with fat mass and cardiovascular risk factors at age 15.
Laura D Howe,Kate Tilling,Li Benfield,Jennifer Logue,Naveed Sattar,Andy R Ness,George Davey Smith,Debbie A Lawlor +7 more
TL;DR: This study suggests that associations between early overweight and subsequent adverse cardiovascular health are largely due to overweight children tending to remain overweight.
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Using Mendelian randomization to determine causal effects of maternal pregnancy (intrauterine) exposures on offspring outcomes: Sources of bias and methods for assessing them
Debbie A Lawlor,Rebecca C Richmond,Nicole M. Warrington,Nicole M. Warrington,George McMahon,George Davey Smith,Jack Bowden,David M. Evans,David M. Evans +8 more
TL;DR: Recommendations that researchers should use when applying MR to test the effects of intrauterine exposures on postnatal offspring outcomes are provided and an illustrative example with real data is used to demonstrate how these can be applied and subsequent results appropriately interpreted.
Journal ArticleDOI
Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype
Paul Brennan,James McKay,Lee E. Moore,David Zaridze,Anush Mukeria,Neonilia Szeszenia-Dabrowska,Jolanta Lissowska,Peter Rudnai,Eleonora Fabianova,Dana Mates,Vladimir Bencko,Lenka Foretova,Vladimir Janout,Wong Ho Chow,Nathaniel Rothman,Amelie Chabrier,Valerie Gaborieau,Nic Timpson,Rayjean J. Hung,Rayjean J. Hung,George Davey Smith +20 more
TL;DR: The results highlight the potential for genetic variation to act as an unconfounded marker of environmentally modifiable factors, and offer the potential to obtain estimates of the causal effect of obesity.