G
George Davey Smith
Researcher at University of Bristol
Publications - 2646
Citations - 294406
George Davey Smith is an academic researcher from University of Bristol. The author has contributed to research in topics: Population & Mendelian randomization. The author has an hindex of 224, co-authored 2540 publications receiving 248373 citations. Previous affiliations of George Davey Smith include Keele University & Western Infirmary.
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Journal ArticleDOI
Maternal Smoking and Child Psychological Problems: Disentangling Causal and Noncausal Effects
Marie-Jo Brion,Cesar G. Victora,Alicia Matijasevich,Bernardo L. Horta,Luciana Anselmi,Colin D Steer,Ana M. B. Menezes,Debbie A Lawlor,George Davey Smith +8 more
TL;DR: Evidence from 4 approaches suggests a possible intrauterine effect of maternal smoking on offspring conduct/externalizing problems.
Posted ContentDOI
Improving the accuracy of two-sample summary data Mendelian randomization: moving beyond the NOME assumption
Jack Bowden,Fabiola M. Del Greco,Cosetta Minelli,Debbie A Lawlor,Nuala A. Sheehan,John Thompson,George Davey Smith +6 more
TL;DR: In this article, a modified 2nd order approximation to the variance of the derived causal estimate is proposed to mitigate the adverse effects of the most popular 2nd-order approximation, leading to an inflation in the chances of detecting heterogeneity when in fact it is not present.
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A genome-wide association study of body mass index across early life and childhood
Nicole M. Warrington,Laura D Howe,Lavinia Paternoster,Marika Kaakinen,Sauli Herrala,Ville Huikari,Y. Wu,John P. Kemp,Nicholas J. Timpson,Beate St Pourcain,George Davey Smith,Kate Tilling,Marjo-Riitta Järvelin,Craig E. Pennell,David M. Evans,Debbie A Lawlor,Laurent Briollais,Lyle J. Palmer +17 more
TL;DR: This genome-wide association study of BMI trajectories over childhood identified a novel locus that warrants further investigation and demonstrated that the use of repeated measures data can increase power to allow detection of genetic loci with smaller sample sizes.
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Genetic Regulation of Birth Weight and Fasting Glucose by a Common Polymorphism in the Islet Cell Promoter of the Glucokinase Gene
Michael N. Weedon,Timothy M. Frayling,Beverley M. Shields,Beatrice Knight,Tina Turner,Bradley S Metcalf,Linda D. Voss,Terence J. Wilkin,Anne Marie McCarthy,Yoav Ben-Shlomo,George Davey Smith,Susan M. Ring,Richard D. Jones,Jean Golding,Liisa Byberg,Vera Mann,Tomas Axelsson,Ann-Christine Syvänen,David A. Leon,Andrew T. Hattersley +19 more
TL;DR: It is established that common genetic variation, in addition to rare mutations and environmental factors, can affect both FPG and birth weight.
Journal ArticleDOI
Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index
Rachel M. Freathy,Gbenga Kazeem,Richard W Morris,Paul C. D. Johnson,Lavinia Paternoster,Shah Ebrahim,Andrew T. Hattersley,Anita Hill,Aroon D. Hingorani,Claus Holst,Barbara J. Jefferis,Sofia I. Iqbal Kring,Vincent Mooser,Sandosh Padmanabhan,Martin Preisig,Susan M. Ring,Naveed Sattar,Mark N. Upton,Peter Vollenweider,Gérard Waeber,Thorkild I. A. Sørensen,Timothy M. Frayling,Graham Watt,Debbie A Lawlor,Peter H. Whincup,Federica Tozzi,George Davey Smith,Marcus R. Munafò +27 more
TL;DR: Smoking status modifies the association between the 15q25 SNP, rs1051730, and BMI, which strengthens evidence that smoking exposure is causally associated with reduced BMI.