G
Gonçalo R. Abecasis
Researcher at University of Michigan
Publications - 629
Citations - 271012
Gonçalo R. Abecasis is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 179, co-authored 595 publications receiving 230323 citations. Previous affiliations of Gonçalo R. Abecasis include Johns Hopkins University School of Medicine & Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
RAREMETAL: fast and powerful meta-analysis for rare variants.
TL;DR: RAREMETAL facilitates analyses of individual studies, accommodates a variety of input file formats, handles related and unrelated individuals, executes both single variant and burden tests and performs conditional association analyses.
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A Fast and Accurate Algorithm to Test for Binary Phenotypes and Its Application to PheWAS
TL;DR: A computationally fast score-test-based method that estimates the distribution of the test statistic by using the saddlepoint approximation that can control type I error rates while replicating previously known association signals even for traits with a very small number of cases and a large number of controls.
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Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants that contribute to lipid levels and coronary artery disease
Xiangfeng Lu,Xiangfeng Lu,Gina M. Peloso,Gina M. Peloso,Dajiang J. Liu,Ying Wu,He Zhang,Wei Zhou,Jun Li,Clara S. Tang,Rajkumar Dorajoo,Huaixing Li,Jirong Long,Xiuqing Guo,Ming Xu,Cassandra N. Spracklen,Yang Chen,Xuezhen Liu,Yan Zhang,Chiea Chuen Khor,Chiea Chuen Khor,Jianjun Liu,Liang Sun,Laiyuan Wang,Yu-Tang Gao,Yao Hu,Kuai Yu,Yiqin Wang,Chloe Y Y Cheung,Feijie Wang,Jianfeng Huang,Jianfeng Huang,Qiao Fan,Qiuyin Cai,Shufeng Chen,Shi Jinxiu,Xueli Yang,Wanting Zhao,Wayne H-H Sheu,Stacey S. Cherny,Meian He,Alan B. Feranil,Linda S. Adair,Penny Gordon-Larsen,Shufa Du,Rohit Varma,Yii-Der Ida Chen,Xiao-Ou Shu,Karen S.L. Lam,Tien Yin Wong,Santhi K. Ganesh,Zengnan Mo,Kristian Hveem,Kristian Hveem,Lars G. Fritsche,Lars G. Fritsche,Jonas B. Nielsen,Hung-Fat Tse,Yong Huo,Ching-Yu Cheng,Y. Eugene Chen,Wei Zheng,E. Shyong Tai,Wei Gao,Xu Lin,Wei Huang,Gonçalo R. Abecasis,Sekar Kathiresan,Sekar Kathiresan,Karen L. Mohlke,Tangchun Wu,Pak C. Sham,Dongfeng Gu,Cristen J. Willer +73 more
TL;DR: The data demonstrate that most of the low-frequency or rare coding variants associated with lipids are population specific, and that examining genomic data across diverse ancestries may facilitate the identification of functional genes at associated loci.
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Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL.
Eva Ellinghaus,Philip E. Stuart,David Ellinghaus,Rajan P. Nair,Sophie Debrus,John Verner Raelson,Majid Belouchi,Trilokraj Tejasvi,Yanming Li,Lam C. Tsoi,Anna T Onken,Tõnu Esko,Andres Metspalu,Proton Rahman,Dafna D. Gladman,Anne M. Bowcock,Cynthia Helms,Gerald G. Krueger,Sulev Kõks,Külli Kingo,Christian Gieger,H.-Erich Wichmann,Ulrich Mrowietz,Stephan Weidinger,Stefan Schreiber,Gonçalo R. Abecasis,James T. Elder,James T. Elder,Michael Weichenthal,Andre Franke +29 more
TL;DR: It is hypothesized that c-Rel, as a member of the Rel/NF-κB family, is associated with PsA in the context of disease pathways that involve other identified PsA and PsV susceptibility genes including TNIP1, TNFAIP3 and NFκBIA.
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Scalable generalized linear mixed model for region-based association tests in large biobanks and cohorts.
Wei Zhou,Zhangchen Zhao,Jonas B. Nielsen,Lars G. Fritsche,Jonathon LeFaive,Sarah A Gagliano Taliun,Wenjian Bi,Maiken Elvestad Gabrielsen,Mark J. Daly,Benjamin M. Neale,Benjamin M. Neale,Kristian Hveem,Gonçalo R. Abecasis,Cristen J. Willer,Seunggeun Lee,Seunggeun Lee +15 more
TL;DR: SAIGE-GENE is a scalable generalized mixed-model region-based association test that can analyze large datasets while accounting for sample relatedness and unbalanced case–control ratios for binary traits.