G
Gonçalo R. Abecasis
Researcher at University of Michigan
Publications - 629
Citations - 271012
Gonçalo R. Abecasis is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 179, co-authored 595 publications receiving 230323 citations. Previous affiliations of Gonçalo R. Abecasis include Johns Hopkins University School of Medicine & Wellcome Trust Centre for Human Genetics.
Papers
More filters
Journal ArticleDOI
Whole-genome sequencing reveals host factors underlying critical COVID-19
Athanasios Kousathanas,Erola Pairo-Castineira,Konrad Rawlik,Alexander Stuckey,Christopher A. Odhams,S. Walker,Clark D Russell,Tomas Malinauskas,Yang Wu,Jonathan E Millar,Xia Shen,Katherine S. Elliott,Fiona Griffiths,Wilna Oosthuyzen,K.W. Morrice,Seán Keating,Bo Wang,Daniel R. Rhodes,Lucija Klaric,Marie Zechner,Nicholas J. Parkinson,Afshan Siddiq,Peter GoddardP. Goddard,Sally Donovan,David M. Maslove,Alistair Nichol,Malcolm G Semple,Tala Zainy,Fiona Maleady-Crowe,L. Todd,Shahla Karbalaei Salehi,Julian C. Knight,Greg Elgar,G. Chan,Prabhu Arumugam,Christine Patch,Augusto Rendon,David Bentley,Clarence D. Kingsley,Jack A. Kosmicki,Julie Horowitz,Aris Baras,Gonçalo R. Abecasis,Manuel A. R. Ferreira,Anne E. Justice,Tooraj Mirshahi,Matthew T. Oetjens,Daniel J. Rader,Marylyn D. Ritchie,Anurag Verma,Tom Fowler,Manu Shankar-Hari,Charlotte Summers,Charles J. Hinds,Peter Horby,Lowell Ling,D. McAuley,Hugh Montgomery,Peter J. M. Openshaw,Paul Elliott,Timothy S. Walsh,Albert Tenesa,Angie Fawkes,Lee Murphy,Kathryn M Rowan,Chris P. Ponting,Veronique Vitart,James F. Wilson,Andrew D. Bretherick,Richard T. Scott,Sara Clohisey Hendry,Loukas Moutsianas,Andy Law,Mark J. Caulfield,J Kenneth Baillie +74 more
TL;DR: The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms as mentioned in this paper .
Journal ArticleDOI
Functional equivalence of genome sequencing analysis pipelines enables harmonized variant calling across human genetics projects
Allison A. Regier,Yossi Farjoun,David E. Larson,Olga Krasheninina,Hyun Min Kang,Daniel P. Howrigan,Bo Juen Chen,Manisha Kher,Eric Banks,Darren C. Ames,Adam C. English,Heng Li,Jinchuan Xing,Yeting Zhang,Tara C. Matise,Gonçalo R. Abecasis,Will Salerno,Michael C. Zody,Benjamin M. Neale,Ira M. Hall +19 more
TL;DR: US genome centers and NIH programs define WGS data processing standards and a flexible validation method, facilitating collaboration in human genetics research.
Journal ArticleDOI
Multiple Loci within the major histocompatibility complex confer risk of psoriasis.
Bing Jian Feng,Liangdan Sun,Razieh Soltani-Arabshahi,Anne M. Bowcock,Rajan P. Nair,Philip E. Stuart,James T. Elder,Steven J. Schrodi,Ann B. Begovich,Gonçalo R. Abecasis,Xuejun Zhang,Kristina Callis-Duffin,Gerald G. Krueger,David E. Goldgar +13 more
TL;DR: It is demonstrated that there are at least two additional loci within the MHC conferring risk of psoriasis within the human leukocyte antigen (HLA) region, independently of HLA-Cw*0602 and the C6orf10 locus, suggesting the potential pathogenic involvement of Hla-B.
Journal ArticleDOI
Elucidating the genetic architecture of familial schizophrenia using rare copy number variant and linkage scans
Bin Xu,Abigail Woodroffe,Laura Rodriguez-Murillo,J. Louw Roos,Elizabeth J. van Rensburg,Gonçalo R. Abecasis,Joseph A. Gogos,Maria Karayiorgou +7 more
TL;DR: The results from approaches designed to detect risk variants with relatively low frequency and high penetrance in a well-defined and relatively homogeneous population, provide strong empirical evidence supporting the notion that multiple genetic variants, including individually rare ones, that affect many different genes contribute to the genetic risk of familial schizophrenia.
Journal ArticleDOI
Exome sequencing and complex disease: practical aspects of rare variant association studies
TL;DR: Practical guidance is provided in the design and analysis of complex trait association studies focused on rare, coding variants to include rare coding variants which often have more marked functional consequences.