G
Gonçalo R. Abecasis
Researcher at University of Michigan
Publications - 629
Citations - 271012
Gonçalo R. Abecasis is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 179, co-authored 595 publications receiving 230323 citations. Previous affiliations of Gonçalo R. Abecasis include Johns Hopkins University School of Medicine & Wellcome Trust Centre for Human Genetics.
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Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Sonia Shah,Albert Henry,Carolina Roselli,Honghuang Lin,Gardar Sveinbjornsson,Ghazaleh Fatemifar,Åsa K. Hedman,Jemma B. Wilk,Michael Morley,Mark Chaffin,Anna Helgadottir,Niek Verweij,Abbas Dehghan,Peter Almgren,Charlotte Andersson,Krishna G. Aragam,Johan Ärnlöv,Joshua D. Backman,Mary L. Biggs,Heather L. Bloom,Jeffrey Brandimarto,Michael R. Brown,Leonard Buckbinder,David J. Carey,Daniel I. Chasman,Xing Chen,Xu Chen,Jonathan H. Chung,William A. Chutkow,James P. Cook,Graciela E. Delgado,Spiros Denaxas,Alex S. F. Doney,Marcus Doerr,Samuel C. Dudley,Michael E. Dunn,Gunnar Engström,Tõnu Esko,Stephan B. Felix,Chris Finan,Ian Ford,Mohsen Ghanbari,Sahar Ghasemi,Vilmantas Giedraitis,Franco Giulianini,John S. Gottdiener,Stefan Gross,Daniel F. Gudbjartsson,Rebecca Gutmann,Christopher M. Haggerty,Pim van der Harst,Craig L. Hyde,Erik Ingelsson,J. Wouter Jukema,Maryam Kavousi,Kay-Tee Khaw,Marcus E. Kleber,Lars Køber,Andrea Koekemoer,Claudia Langenberg,Lars Lind,Cecilia M. Lindgren,Barry London,Luca A. Lotta,Ruth C. Lovering,Jian'an Luan,Patrik K. E. Magnusson,Anubha Mahajan,Kenneth B. Margulies,Winfried Maerz,Olle Melander,Ify R. Mordi,Thomas M. Morgan,Andrew D. Morris,Andrew P. Morris,Alanna C. Morrison,Michael W. Nagle,Christopher P. Nelson,Alexander Niessner,Teemu J. Niiranen,Michelle L. O'Donoghue,Anjali T. Owens,Colin N. A. Palmer,Helen M. Parry,Markus Perola,Eliana Portilla-Fernandez,Bruce M. Psaty,Kenneth Rice,Paul M. Ridker,Simon P. R. Romaine,Jerome I. Rotter,Perttu Salo,Veikko Salomaa,Jessica van Setten,Alaa Shalaby,Diane T. Smelser,Nicholas L. Smith,Steen Stender,David J. Stott,Per Svensson,Mari-Liis Tammesoo,Kent D. Taylor,Maris Teder-Laving,Alexander Teumer,Gudmundur Thorgeirsson,Unnur Thorsteinsdottir,Christian Torp-Pedersen,Stella Trompet,Benoit Tyl,André G. Uitterlinden,Abirami Veluchamy,Uwe Voelker,Adriaan A. Voors,Xiaosong Wang,Nicholas J. Wareham,Dawn M. Waterworth,Peter Weeke,Raul Weiss,Kerri L. Wiggins,Heming Xing,Laura M. Yerges-Armstrong,Bing Yu,Faiez Zannad,Jing Hua Zhao,Harry Hemingway,Nilesh J. Samani,John J.V. McMurray,Jian Yang,Peter M. Visscher,Christopher Newton-Cheh,Anders Mälarstig,Hilma Holm,Steven A. Lubitz,Naveed Sattar,Michael V. Holmes,Thomas P. Cappola,Folkert W. Asselbergs,Aroon D. Hingorani,Karoline Kuchenbaecker,Patrick T. Ellinor,Chim C. Lang,Kari Stefansson,J. Gustav Smith,Ramachandran S. Vasan,Daniel I. Swerdlow,R. Thomas Lumbers,Gonçalo R. Abecasis,Joshua D. Backman,Xiaodong Bai,Suganthi Balasubramanian,Nilanjana Banerjee,Aris Baras,Leland Barnard,Christina Beechert,Andrew Blumenfeld,Michael N. Cantor,Yating Chai,Giovanni Coppola,Amy Damask,Frederick E. Dewey,Aris N. Economides,Gisu Eom,Caitlin Forsythe,Erin D. Fuller,Zhenhua Gu,Lauren Gurski,Paloma M. Guzzardo,Lukas Habegger,Young Hahn,Alicia Hawes,Cristopher V. Van Hout,Marcus B. Jones,Shareef Khalid,Michael Lattari,Alexander H. Li,Nan Lin,Daren Liu,Alexander Lopez,Kia Manoochehri,Jonathan Marchini,Anthony Marcketta,Evan Maxwell,Shane A. McCarthy,Lyndon J. Mitnaul,Colm O'Dushlaine,John D. Overton,Maria Sotiropoulos Padilla,Charles Paulding,John Penn,Manasi Pradhan,Jeffrey G. Reid,Thomas D. Schleicher,Claudia Schurmann,Alan R. Shuldiner,Jeffrey Staples,Dylan Sun,Karina Toledo,Ricardo H. Ulloa,Louis Widom,Sarah E. Wolf,Ashish Yadav,Bin Ye +201 more
TL;DR: In this paper, the authors report results from a genome-wide association studies (GWAS) meta-analysis of heart failure comprising 47,309 cases and 930,014 controls.
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A genome-wide association study on African-ancestry populations for asthma.
Rasika A. Mathias,Audrey V. Grant,Nicholas Rafaels,T. Hand,Li Gao,Candelaria Vergara,Yuhjung J. Tsai,Mao Yang,Monica Campbell,Cassandra Foster,Peisong Gao,Alkis Togias,Nadia N. Hansel,Gregory B. Diette,N. Franklin Adkinson,Mark C. Liu,Mezbah U. Faruque,Georgia M. Dunston,Harold Watson,Michael B. Bracken,Josephine Hoh,Pissamai Maul,Trevor Maul,Anne E. Jedlicka,Tanda Murray,Jacqueline B. Hetmanski,Roxann Ashworth,Chrissie M. Ongaco,Kurt N. Hetrick,Kimberly F. Doheny,Elizabeth W. Pugh,Charles N. Rotimi,Jean G. Ford,Celeste Eng,Esteban G. Burchard,Patrick M. A. Sleiman,Hakon Hakonarson,Erick Forno,Benjamin A. Raby,Scott T. Weiss,Alan F. Scott,Michael Kabesch,Liming Liang,Gonçalo R. Abecasis,Miriam F. Moffatt,William O.C.M. Cookson,Ingo Ruczinski,Terri H. Beaty,Kathleen C. Barnes +48 more
TL;DR: This study illustrates the complexity of identifying true associations for a complex and heterogeneous disease, such as asthma, in admixed populations, especially populations of African descent.
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Meta-analysis of gene-level tests for rare variant association
Dajiang J. Liu,Gina M. Peloso,Xiaowei Zhan,Oddgeir L. Holmen,Matthew Zawistowski,Shuang Feng,Majid Nikpay,Paul L. Auer,Paul L. Auer,Anuj Goel,He Zhang,Ulrike Peters,Ulrike Peters,Martin Farrall,Marju Orho-Melander,Marju Orho-Melander,Charles Kooperberg,Charles Kooperberg,Ruth McPherson,Hugh Watkins,Cristen J. Willer,Kristian Hveem,Olle Melander,Olle Melander,Sekar Kathiresan,Gonçalo R. Abecasis +25 more
TL;DR: The approach retains useful features from single-variant meta-analysis approaches and is demonstrated to use in a study of blood lipid levels in ∼18,500 individuals genotyped with exome arrays.
Journal ArticleDOI
Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin
Lam C. Tsoi,Matthew K. Iyer,Philip E. Stuart,William R. Swindell,Johann E. Gudjonsson,Trilokraj Tejasvi,Mrinal K. Sarkar,Bingshan Li,Bingshan Li,Jun Ding,Jun Ding,John J. Voorhees,Hyun Min Kang,Rajan P. Nair,Arul M. Chinnaiyan,Gonçalo R. Abecasis,James T. Elder +16 more
TL;DR: It is found that many lncRNAs, in particular those that are differentially expressed, are co-expressed with genes involved in immune related functions, and that novel lnc RNAs are enriched for localization in the epidermal differentiation complex.
Journal ArticleDOI
Meta-analysis of Genome-Wide Association Studies From the CHARGE Consortium Identifies Common Variants Associated With Carotid Intima Media Thickness and Plaque
Joshua C. Bis,Maryam Kavousi,Nora Franceschini,Aaron Isaacs,Gonçalo R. Abecasis,Ulf Schminke,Wendy S. Post,Albert V. Smith,L. Adrienne Cupples,L. Adrienne Cupples,Hugh S. Markus,Reinhold Schmidt,Jennifer E. Huffman,Terho Lehtimäki,Jens Baumert,Thomas Münzel,Susan R. Heckbert,Susan R. Heckbert,Abbas Dehghan,Kari E. North,Ben A. Oostra,Steve Bevan,Eva Maria Stoegerer,Caroline Hayward,Olli T. Raitakari,Christa Meisinger,Arne Schillert,Serena Sanna,Henry Völzke,Yu-Ching Cheng,Bolli Thorsson,Caroline S. Fox,Caroline S. Fox,Kenneth Rice,Fernando Rivadeneira,Vijay Nambi,Vijay Nambi,Eran Halperin,Eran Halperin,Katja Petrovic,Leena Peltonen,Leena Peltonen,H.-Erich Wichmann,Renate B. Schnabel,Marcus Dörr,Afshin Parsa,Thor Aspelund,Serkalem Demissie,Sekar Kathiresan,Sekar Kathiresan,Muredach P. Reilly,Kent D. Taylor,André G. Uitterlinden,David Couper,Matthias Sitzer,Mika Kähönen,Thomas Illig,Philipp S. Wild,Marco Orru,Jan Lüdemann,Alan R. Shuldiner,Alan R. Shuldiner,Gudny Eiriksdottir,Charles C. White,Jerome I. Rotter,Albert Hofman,Jochen Seissler,Tanja Zeller,Gianluca Usala,Florian Ernst,Lenore J. Launer,Ralph B. D'Agostino,Daniel H. O'Leary,Christie M. Ballantyne,Joachim Thiery,Andreas Ziegler,Edward G. Lakatta,Ravi Kumar Chilukoti,Tamara B. Harris,Philip A. Wolf,Philip A. Wolf,Bruce M. Psaty,Bruce M. Psaty,Joseph F. Polak,Xia Li,Wolfgang Rathmann,Manuela Uda,Eric Boerwinkle,Norman Klopp,Helena Schmidt,James F. Wilson,Jorma Viikari,Wolfgang Koenig,Stefan Blankenberg,Anne B. Newman,Jacqueline C.M. Witteman,Gerardo Heiss,Cornelia M. van Duijn,Angelo Scuteri,Georg Homuth,Braxton D. Mitchell,Vilmundur Gudnason,Christopher J. O'Donnell,Christopher J. O'Donnell +103 more
TL;DR: A meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium identified three genomic regions associated with common carotid intima media thickness and two different areas associated with the presence of carotids plaque.