G
Gonçalo R. Abecasis
Researcher at University of Michigan
Publications - 629
Citations - 271012
Gonçalo R. Abecasis is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 179, co-authored 595 publications receiving 230323 citations. Previous affiliations of Gonçalo R. Abecasis include Johns Hopkins University School of Medicine & Wellcome Trust Centre for Human Genetics.
Papers
More filters
Journal ArticleDOI
Mapping the 17q12-21.1 Locus for Variants Associated with Early-onset Asthma in African Americans
Hongsheng Gui,Albert M. Levin,Donglei Hu,Patrick M. A. Sleiman,Shujie Xiao,Angel C.Y. Mak,Mao Yang,Andrea J. Barczak,Scott Huntsman,Celeste Eng,Samantha Hochstadt,Ellen Zhang,Kyle Whitehouse,Samantha Simons,Whitney Cabral,Sami Takriti,Gonçalo R. Abecasis,Thomas W. Blackwell,Hyun Min Kang,Deborah A. Nickerson,Soren Germer,David E. Lanfear,Frank D. Gilliland,W. James Gauderman,Rajesh Kumar,David J. Erle,Fernando D. Martinez,Hakon Hakonarson,Esteban G. Burchard,L. Keoki Williams +29 more
TL;DR: A splice acceptor polymorphism appears to be a causal variant for asthma at the 17q12-21.1 locus that appears to have the same magnitude of effect in individuals of African and European descent.
Journal ArticleDOI
Correction: Corrigendum: Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies
TL;DR: In Table 1 of the versions of this article initially published online and in print, the significance thresholds for C2 were incorrect, and the significance threshold for Cjoint in the case of πsamples = 0.20 were incorrect.
Posted ContentDOI
Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries
Jason Flannick,Josep M. Mercader,Christian Fuchsberger,Miriam S. Udler,Anubha Mahajan,Jennifer Wessel,Tanya M. Teslovich,Lizz Caulkins,Ryan Koesterer,Thomas W. Blackwell,Eric Boerwinkle,Eric Boerwinkle,Jennifer A. Brody,Lin Chen,Song Chen,Cecilia Contreras-Cubas,Emilio J. Cordova,Adolfo Correa,Maria L. Cortes,Ralph A. DeFronzo,Lawrence M. Dolan,Kimberly L. Drews,Amanda F. Elliott,Amanda F. Elliott,James S. Floyd,S. Gabriel,Garay-Sevilla Me,Humberto García-Ortiz,Myron D. Gross,Sohee Han,Hanks S,Nancy L. Heard-Costa,Anne U. Jackson,Marit E. Jørgensen,Marit E. Jørgensen,Marit E. Jørgensen,Hyun Min Kang,Kelsey M,Bong-Jo Kim,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Johanna Kuusisto,Joseph B. Leader,Allan Linneberg,Allan Linneberg,Ching-Ti Liu,Jianjun Liu,Jianjun Liu,Lyssenko,Lyssenko,Alisa K. Manning,Anthony Marcketta,Malacara-Hernandez Jm,Angélica Martínez-Hernández,Matsuo K,Elizabeth J. Mayer-Davis,Elvia Mendoza-Caamal,Karen L. Mohlke,Alanna C. Morrison,Anne Ndungu,Maggie C.Y. Ng,Colm O'Dushlaine,Anthony Payne,Catherine Pihoker,Wendy S. Post,Michael Preuss,Bruce M. Psaty,Bruce M. Psaty,Ramachandran S. Vasan,Rayner Nw,Alexander P. Reiner,Cristina Revilla-Monsalve,Neil R. Robertson,Nicola Santoro,Claudia Schurmann,Wing-Yee So,Heather M. Stringham,T. M. Strom,Claudia Ht Tam,Farook Thameem,Brian Tomlinson,Jason M. Torres,Russel Tracy,van Dam Rm,Marijana Vujkovic,Shuai Wang,Ryan P. Welch,Daniel R. Witte,Tien Yin Wong,Gil Atzmon,Gil Atzmon,Nir Barzilai,John Blangero,Lori L. Bonnycastle,Donald W. Bowden,John C. Chambers,John C. Chambers,John C. Chambers,Edmund Chan,Ching-Yu Cheng,Shin Yc,Francis S. Collins,de Vries Ps,Ravindranath Duggirala,Benjamin Glaser,Clicerio Gonzalez,Ma Elena Gonzalez,Leif Groop,Leif Groop,Jaspal S. Kooner,Soo Heon Kwak,Markku Laakso,Donna M. Lehman,Peter M. Nilsson,Tim D. Spector,Tai Es,Tiinamaija Tuomi,J. Tuomilehto,James G. Wilson,Carlos A. Aguilar-Salinas,Erwin P. Bottinger,Brian Burke,David J. Carey,Juliana C.N. Chan,Josée Dupuis,Philippe M. Frossard,Heckbert,Mi Yeong Hwang,Young-Jin Kim,Kirchner Hl,Lee J,Loos R,Ronald C.W. Ma,Morris Ad,C.J. O'Donnell,Colin N. A. Palmer,James S. Pankow,Ki-Sun Park,Ki-Sun Park,Ki-Sun Park,Asif Rasheed,Danish Saleheen,Xueling Sim,Kerrin S. Small,Yik Ying Teo,Christopher A. Haiman,Craig L. Hanis,Brian E. Henderson,Lorena Orozco,Teresa Tusié-Luna,Frederick E. Dewey,Aris Baras,Christian Gieger,Thomas Meitinger,Konstantin Strauch,Leslie A. Lange,Niels Grarup,Torben Hansen,Torben Hansen,Oluf Pedersen,Zeitler P,Dana Dabelea,Gonçalo R. Abecasis,Graeme I. Bell,Nancy J. Cox,Mark Seielstad,Mark Seielstad,Robert Sladek,James B. Meigs,James B. Meigs,S. S. Rich,Jerome I. Rotter,David Altshuler,Noël P. Burtt,Laura J. Scott,Andrew P. Morris,Jose C. Florez,Mark I. McCarthy,Boehnke M +179 more
TL;DR: An exome sequence analysis of type 2 diabetes cases and controls presents a Bayesian framework to recalibrate association p-values as posterior probabilities of association, estimating that reaching p<0.05 in this study increases the odds of causal T2D association for a nonsynonymous variant by a factor of 1.3.
Journal ArticleDOI
Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder.
Xiaoming Jia,Fernando S. Goes,Adam E. Locke,Duncan Palmer,Weiqing Wang,Sarah Cohen-Woods,Sarah Cohen-Woods,Giulio Genovese,Anne U. Jackson,Chen Jiang,Mark N. Kvale,Niamh Mullins,Hoang T. Nguyen,Mehdi Pirooznia,Margarita Rivera,Margarita Rivera,Douglas M. Ruderfer,Ling Shen,Khanh K. Thai,Matthew Zawistowski,Yongwen Zhuang,Gonçalo R. Abecasis,Huda Akil,Sarah E. Bergen,Margit Burmeister,Sinéad B. Chapman,Melissa DelaBastide,Anders Juréus,Hyun Min Kang,Pui-Yan Kwok,Jun Li,Shawn Levy,Eric T. Monson,Jennifer L. Moran,Janet L. Sobell,Stanley J. Watson,Virginia L. Willour,Sebastian Zöllner,Rolf Adolfsson,Douglas Blackwood,Michael Boehnke,Gerome Breen,Aiden Corvin,Nicholas John Craddock,Arianna DiFlorio,Christina M. Hultman,Mikael Landén,Mikael Landén,Cathryn M. Lewis,Steven A. McCarroll,W. Richard McCombie,Peter McGuffin,Andrew M. McIntosh,Andrew McQuillin,Derek W. Morris,Derek W. Morris,Richard M. Myers,Michael Conlon O'Donovan,Roel A. Ophoff,Marco P. Boks,René S. Kahn,Willem H. Ouwehand,Michael John Owen,Carlos N. Pato,Carlos N. Pato,Michele T. Pato,Michele T. Pato,Danielle Posthuma,James B. Potash,Andreas Reif,Pamela Sklar,Jordan W. Smoller,Jordan W. Smoller,Patrick F. Sullivan,John B. Vincent,John B. Vincent,James T.R. Walters,Benjamin M. Neale,Benjamin M. Neale,Shaun Purcell,Shaun Purcell,Neil Risch,Catherine Schaefer,Eli A. Stahl,Peter P. Zandi,Laura J. Scott +85 more
TL;DR: In this article, the authors examined the protein-coding (exonic) sequences of 3,987 unrelated individuals with bipolar disorder and 5,322 controls of predominantly European ancestry across four cohorts from the Bipolar Sequencing Consortium (BSC).
Posted ContentDOI
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies
Wei Zhou,Jonas B. Nielsen,Lars G. Fritsche,Rounak Dey,Maiken Elvestad Gabrielsen,Brooke N. Wolford,Jonathon LeFaive,Peter VandeHaar,Aliya Gifford,Lisa Bastarache,Wei-Qi Wei,Joshua C. Denny,Maoxuan Lin,Kristian Hveem,Hyun Min Kang,Gonçalo R. Abecasis,Cristen J. Willer,Seunggeun Lee +17 more
TL;DR: It is shown that SAIGE can efficiently analyze large sample data, controlling for unbalanced case-control ratios and sample relatedness, and can be applicable to GWAS for thousands of phenotypes by large biobanks.