G
Gonçalo R. Abecasis
Researcher at University of Michigan
Publications - 629
Citations - 271012
Gonçalo R. Abecasis is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 179, co-authored 595 publications receiving 230323 citations. Previous affiliations of Gonçalo R. Abecasis include Johns Hopkins University School of Medicine & Wellcome Trust Centre for Human Genetics.
Papers
More filters
Journal ArticleDOI
Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations
Toshiko Tanaka,Paul Scheet,Betti Giusti,Stefania Bandinelli,Maria Grazia Piras,Gianluca Usala,Sandra Lai,Antonella Mulas,Anna Maria Corsi,Anna Vestrini,Francesco Sofi,Anna Maria Gori,Rosanna Abbate,Jack M. Guralnik,Andrew B. Singleton,Gonçalo R. Abecasis,David Schlessinger,Manuela Uda,Luigi Ferrucci +18 more
TL;DR: The association of MTHFR, a gene consistently associated with homocysteine, was confirmed in this meta-analysis and the ALPL gene likely influences the catabolism of vitamin B6 while FUT2 interferes with absorption of Vitamin B12.
Exome-wide association study of plasma lipids in > 300,000 individuals
Dajiang J. Liu,Gina M. Peloso,Haojie Yu,Adam S. Butterworth,Xiao Wang,Anubha Mahajan,Danish Saleheen,Connor A. Emdin,Dewan S. Alam,Alexessander Couto Alves,Philippe Amouyel,Emanuele Di Angelantonio,Dominique Arveiler,Themistocles L. Assimes,Paul L. Auer,Usman Baber,Christie M. Ballantyne,Lia E. Bang,Marianne Benn,Joshua C. Bis,Michael Boehnke,Eric Boerwinkle,Jette Bork-Jensen,Erwin P. Bottinger,Ivan Brandslund,Morris J. Brown,Fabio Busonero,Mark J. Caulfield,John C. Chambers,Daniel I. Chasman,Y. Eugene Chen,Yii-Der Ida Chen,Rajiv Chowdhury,Cramer Christensen,Audrey Y. Chu,John M. C. Connell,Francesco Cucca,L. Adrienne Cupples,Scott M. Damrauer,Gail Davies,Ian J. Deary,George Dedoussis,Joshua C. Denny,Anna F. Dominiczak,Marie-Pierre Dubé,Tapani Ebeling,Gudny Eiriksdottir,Tõnu Esko,Aliki-Eleni Farmaki,Mary F. Feitosa,Marco M Ferrario,Jean Ferrières,Ian Ford,Myriam Fornage,Paul W. Franks,Timothy M. Frayling,Ruth Frikke-Schmidt,Lars G. Fritsche,Philippe M. Frossard,Valentin Fuster,Santhi K. Ganesh,Wei Gao,Melissa E. Garcia,Christian Gieger,Franco Giulianini,Mark O. Goodarzi,Harald Grallert,Niels Grarup,Leif Groop,Megan L. Grove,Vilmundur Gudnason,Torben Hansen,Tamara B. Harris,Caroline Hayward,Joel N. Hirschhorn,Oddgeir L. Holmen,Jennifer E. Huffman,Yong Huo,Kristian Hveem,Sehrish Jabeen,Anne U. Jackson,Johanna Jakobsdottir,Marjo-Riitta Järvelin,Gorm B. Jensen,Marit E. Jørgensen,J. Wouter Jukema,Johanne Marie Justesen,Pia R. Kamstrup,Stavroula Kanoni,Fredrik Karpe,Frank Kee,Amit Khera,Derek Klarin,Heikki A. Koistinen,Jaspal S. Kooner,Charles Kooperberg,Kari Kuulasmaa,Johanna Kuusisto,Markku Laakso,Timo A. Lakka,Claudia Langenberg,Anne Langsted,Lenore J. Launer,Torsten Lauritzen,David C. Liewald,Li-An Lin,Allan Linneberg,Ruth J. F. Loos,Yingchang Lu,Xiangfeng Lu,Reedik Mägi,Anders Mälarstig,Ani Manichaikul,Alisa K. Manning,Pekka Mäntyselkä,Eirini Marouli,Nicholas G. D. Masca,Andrea Maschio,James B. Meigs,Olle Melander,Andres Metspalu,Andrew P. Morris,Alanna C. Morrison,Antonella Mulas,Martina Mueller-Nurasyid,Patricia B. Munroe,Matt Neville,Jonas B. Nielsen,Sune F. Nielsen,Børge G. Nordestgaard,Jose M. Ordovas,Roxana Mehran,C.J. O'Donnell,Marju Orho-Melander,Cliona Molony,Pieter Muntendam,Sandosh Padmanabhan,Colin N. A. Palmer,Dorota Pasko,Aniruddh P. Patel,Oluf Pedersen,Markus Perola,Annette Peters,Charlotta Pisinger,Giorgio Pistis,Ozren Polasek,Neil Poulter,Bruce M. Psaty,Daniel J. Rader,Asif Rasheed,Rainer Rauramaa,Dermot F. Reilly,Alexander P. Reiner,Frida Renström,Stephen S. Rich,Paul M. Ridker,John D. Rioux,Neil R. Robertson,Dan M. Roden,Jerome I. Rotter,Igor Rudan,Veikko Salomaa,Nilesh J. Samani,Serena Sanna,Naveed Sattar,Ellen M. Schmidt,Robert A. Scott,Peter S. Sever,Raquel S. Sevilla,Christian M. Shaffer,Xueling Sim,Suthesh Sivapalaratnam,Kerrin S. Small,Albert V. Smith,Blair H. Smith,Sangeetha Somayajula,Lorraine Southam,Tim D. Spector,Elizabeth K. Speliotes,John M. Starr,Kathleen Stirrups,Nathan O. Stitziel,Konstantin Strauch,Heather M. Stringham,Praveen Surendran,Hayato Tada,Alan R. Tall,Hua Tang,Jean-Claude Tardif,Kent D. Taylor,Stella Trompet,Philip S. Tsao,Jaakko Tuomilehto,Anne Tybjærg-Hansen,Natalie R. van Zuydam,Anette Varbo,Tibor V. Varga,Jarmo Virtamo,Melanie Waldenberger,Nan Wang,Nicholas J. Wareham,Helen R. Warren,Peter Weeke,Joshua S. Weinstock,Jennifer Wessel,James G. Wilson,Peter W.F. Wilson,Ming Xu,Hanieh Yaghootkar,Robin Young,Eleftheria Zeggini,He Zhang,Neil S Zheng,Weihua Zhang,Yan Zhang,Wei Zhou,Yanhua Zhou,Magdalena Zoledziewska,Joanna M. M. Howson,John Danesh,Mark I. McCarthy,Chad A. Cowan,Gonçalo R. Abecasis,Panos Deloukas,Kiran Musunuru,Cristen J. Willer,Sekar Kathiresan +226 more
Journal ArticleDOI
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Valérie Turcot,Yingchang Lu,Yingchang Lu,Heather M. Highland,Heather M. Highland,Claudia Schurmann,Anne E. Justice,Rebecca S. Fine,Rebecca S. Fine,Jonathan P. Bradfield,Tõnu Esko,Tõnu Esko,Tõnu Esko,Ayush Giri,Mariaelisa Graff,Xiuqing Guo,Audrey E. Hendricks,Audrey E. Hendricks,Tugce Karaderi,Tugce Karaderi,Adelheid Lempradl,Adam E. Locke,Adam E. Locke,Anubha Mahajan,Eirini Marouli,Suthesh Sivapalaratnam,Suthesh Sivapalaratnam,Suthesh Sivapalaratnam,Kristin L. Young,Tamuno Alfred,Mary F. Feitosa,Nicholas G. D. Masca,Nicholas G. D. Masca,Alisa K. Manning,Alisa K. Manning,Carolina Medina-Gomez,Poorva Mudgal,Maggie C.Y. Ng,Alexander P. Reiner,Alexander P. Reiner,Sailaja Vedantam,Sailaja Vedantam,Sara M. Willems,Thomas W. Winkler,Gonçalo R. Abecasis,Katja K.H. Aben,Dewan S. Alam,Sameer E. Al-Harthi,Sameer E. Al-Harthi,Matthew A. Allison,Philippe Amouyel,Philippe Amouyel,Philippe Amouyel,Folkert W. Asselbergs,Folkert W. Asselbergs,Paul L. Auer,Beverley Balkau,Lia E. Bang,Inês Barroso,Inês Barroso,Lisa Bastarache,Marianne Benn,Sven Bergmann,Sven Bergmann,Lawrence F. Bielak,Matthias Blüher,Michael Boehnke,Heiner Boeing,Eric Boerwinkle,Eric Boerwinkle,Carsten A. Böger,Jette Bork-Jensen,Michiel L. Bots,Erwin P. Bottinger,Donald W. Bowden,Ivan Brandslund,Gerome Breen,Gerome Breen,Murray H. Brilliant,Linda Broer,Marco Brumat,Amber A. Burt,Adam S. Butterworth,Peter T. Campbell,Stefania Cappellani,David J. Carey,Eulalia Catamo,Mark J. Caulfield,John C. Chambers,John C. Chambers,Daniel I. Chasman,Daniel I. Chasman,Yii-Der Ida Chen,Rajiv Chowdhury,Cramer Christensen,Audrey Y. Chu,Audrey Y. Chu,Massimiliano Cocca,Francis S. Collins,James P. Cook,Janie Corley,Jordi Corominas Galbany,Amanda J. Cox,Amanda J. Cox,David S. Crosslin,Gabriel Cuellar-Partida,Gabriel Cuellar-Partida,Angela D'Eustacchio,John Danesh,John Danesh,Gail Davies,Gail Davies,Paul I.W. de Bakker,Mark C.H. De Groot,Renée de Mutsert,Ian J. Deary,Ian J. Deary,George Dedoussis,Ellen W. Demerath,Martin den Heijer,Anneke I. den Hollander,Hester M. den Ruijter,Joe Dennis,Josh C. Denny,Emanuele Di Angelantonio,Fotios Drenos,Fotios Drenos,Mengmeng Du,Mengmeng Du,Marie-Pierre Dubé,Alison M. Dunning,Douglas F. Easton,Todd L. Edwards,David Ellinghaus,Patrick T. Ellinor,Patrick T. Ellinor,Paul Elliott,Evangelos Evangelou,Evangelos Evangelou,Aliki-Eleni Farmaki,Aliki-Eleni Farmaki,I. Sadaf Farooqi,Jessica D. Faul,Sascha Fauser,Shuang Feng,Ele Ferrannini,Jean Ferrières,Jose C. Florez,Jose C. Florez,Ian Ford,Myriam Fornage,Oscar H. Franco,Andre Franke,Paul W. Franks,Paul W. Franks,Paul W. Franks,Nele Friedrich,Ruth Frikke-Schmidt,Tessel E. Galesloot,Wei Gan,Ilaria Gandin,Paolo Gasparini,Jane Gibson,Vilmantas Giedraitis,Anette P. Gjesing,Penny Gordon-Larsen,Mathias Gorski,Hans-Jörgen Grabe,Hans-Jörgen Grabe,Struan F.A. Grant,Niels Grarup,Helen Griffiths,Megan L. Grove,Vilmundur Gudnason,Stefan Gustafsson,Jeffrey Haessler,Hakon Hakonarson,Anke R. Hammerschlag,Torben Hansen,Kathleen Mullan Harris,Tamara B. Harris,Andrew T. Hattersley,Christian Theil Have,Caroline Hayward,Liang He,Liang He,Nancy L. Heard-Costa,Nancy L. Heard-Costa,Andrew C. Heath,Iris M. Heid,Øyvind Helgeland,Jussi Hernesniemi,Alex W. Hewitt,Alex W. Hewitt,Alex W. Hewitt,Oddgeir L. Holmen,G. Kees Hovingh,Joanna M. M. Howson,Yao Hu,Paul L. Huang,Jennifer E. Huffman,M. Arfan Ikram,Erik Ingelsson,Erik Ingelsson,Anne U. Jackson,Jan-Håkan Jansson,Gail P. Jarvik,Gorm B. Jensen,Yucheng Jia,Stefan Johansson,Marit E. Jørgensen,Marit E. Jørgensen,Torben Jørgensen,Torben Jørgensen,J. Wouter Jukema,Bratati Kahali,Bratati Kahali,René S. Kahn,Mika Kähönen,Pia R. Kamstrup,Stavroula Kanoni,Jaakko Kaprio,Jaakko Kaprio,Maria Karaleftheri,Sharon L.R. Kardia,Fredrik Karpe,Sekar Kathiresan,Sekar Kathiresan,Frank Kee,Lambertus A. Kiemeney,Eric Kim,Hidetoshi Kitajima,Pirjo Komulainen,Jaspal S. Kooner,Jaspal S. Kooner,Charles Kooperberg,Tellervo Korhonen,Tellervo Korhonen,Tellervo Korhonen,Peter Kovacs,Helena Kuivaniemi,Helena Kuivaniemi,Zoltán Kutalik,Zoltán Kutalik,Kari Kuulasmaa,Johanna Kuusisto,Markku Laakso,Timo A. Lakka,David Lamparter,David Lamparter,Ethan M. Lange,Leslie A. Lange,Claudia Langenberg,Eric B. Larson,Eric B. Larson,Nanette R. Lee,Terho Lehtimäki,Cora E. Lewis,Huaixing Li,Jin Li,Ruifang Li-Gao,Honghuang Lin,Keng-Hung Lin,Li-An Lin,Xu Lin,Lars Lind,Jaana Lindström,Allan Linneberg,Ching-Ti Liu,Dajiang J. Liu,Yongmei Liu,Ken Sin Lo,Artitaya Lophatananon,Andrew J. Lotery,Anu Loukola,Jian'an Luan,Steven A. Lubitz,Steven A. Lubitz,Leo-Pekka Lyytikäinen,Satu Männistö,Gaëlle Marenne,Angela L. Mazul,Mark I. McCarthy,Roberta McKean-Cowdin,Sarah E. Medland,Karina Meidtner,Lili Milani,Vanisha Mistry,Paul Mitchell,Karen L. Mohlke,Leena Moilanen,Marie Moitry,Grant W. Montgomery,Grant W. Montgomery,Dennis O. Mook-Kanamori,Carmel Moore,Trevor A. Mori,Andrew D. Morris,Andrew P. Morris,Andrew P. Morris,Martina Müller-Nurasyid,Patricia B. Munroe,Mike A. Nalls,Narisu Narisu,Christopher P. Nelson,Christopher P. Nelson,Matt Neville,Sune F. Nielsen,Kjell Nikus,Pål R. Njølstad,Børge G. Nordestgaard,Dale R. Nyholt,Dale R. Nyholt,Jeffrey R. O'Connel,Michelle L. O'Donoghue,Loes M. Olde Loohuis,Roel A. Ophoff,Roel A. Ophoff,Katharine R. Owen,Chris J. Packard,Sandosh Padmanabhan,Colin N. A. Palmer,Nicholette D. Palmer,Gerard Pasterkamp,Aniruddh P. Patel,Aniruddh P. Patel,Alison Pattie,Oluf Pedersen,Peggy L. Peissig,Gina M. Peloso,Craig E. Pennell,Markus Perola,Markus Perola,Markus Perola,James A. Perry,John R. B. Perry,Tune H. Pers,Tune H. Pers,Thomas N. Person,Annette Peters,Eva Rb Petersen,Patricia A. Peyser,Ailith Pirie,Ozren Polasek,Ozren Polasek,Tinca J. C. Polderman,Hannu Puolijoki,Olli T. Raitakari,Asif Rasheed,Rainer Rauramaa,Dermot F. Reilly,Frida Renström,Frida Renström,Myriam Rheinberger,Paul M. Ridker,John D. Rioux,Manuel A. Rivas,Manuel A. Rivas,David J. Roberts,David J. Roberts,David J. Roberts,Neil R. Robertson,Antonietta Robino,Olov Rolandsson,Igor Rudan,Katherine S. Ruth,Danish Saleheen,Veikko Salomaa,Nilesh J. Samani,Nilesh J. Samani,Yadav Sapkota,Naveed Sattar,Robert E. Schoen,Pamela J. Schreiner,Matthias B. Schulze,Robert A. Scott,Marcelo P. Segura-Lepe,Svati H. Shah,Wayne H-H Sheu,Wayne H-H Sheu,Xueling Sim,Xueling Sim,Andrew J. Slater,Kerrin S. Small,Albert V. Smith,Lorraine Southam,Lorraine Southam,Tim D. Spector,Elizabeth K. Speliotes,John M. Starr,Kari Stefansson,Kari Stefansson,Valgerdur Steinthorsdottir,Kathleen Stirrups,Kathleen Stirrups,Konstantin Strauch,Heather M. Stringham,Michael Stumvoll,Liang Sun,Liang Sun,Praveen Surendran,Amy J. Swift,Hayato Tada,Hayato Tada,Katherine E. Tansey,Katherine E. Tansey,Jean-Claude Tardif,Kent D. Taylor,Alexander Teumer,Deborah J. Thompson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Betina H. Thuesen,Anke Tönjes,Gerard Tromp,Gerard Tromp,Stella Trompet,Emmanouil Tsafantakis,Jaakko Tuomilehto,Anne Tybjærg-Hansen,Jonathan Tyrer,Rudolf Uher,André G. Uitterlinden,Matti Uusitupa,Sander W. van der Laan,Cornelia M. van Duijn,Nienke van Leeuwen,Nienke van Leeuwen,Jessica van Setten,Mauno Vanhala,Anette Varbo,Tibor V. Varga,Rohit Varma,Digna R. Velez Edwards,Sita H. Vermeulen,Giovanni Veronesi,Henrik Vestergaard,Henrik Vestergaard,Veronique Vitart,Thomas F. Vogt,Uwe Völker,Dragana Vuckovic,Lynne E. Wagenknecht,Mark Walker,Lars Wallentin,Feijie Wang,Carol A. Wang,Shuai Wang,Yiqin Wang,Erin B. Ware,Nicholas J. Wareham,Helen R. Warren,Dawn M. Waterworth,Jennifer Wessel,Harvey D. White,Cristen J. Willer,James G. Wilson,Daniel R. Witte,Andrew R. Wood,Ying Wu,Hanieh Yaghootkar,Jie Yao,Pang Yao,Laura M. Yerges-Armstrong,Laura M. Yerges-Armstrong,Robin Young,Robin Young,Eleftheria Zeggini,Xiaowei Zhan,Weihua Zhang,Weihua Zhang,Jing Hua Zhao,Wei Zhao,Wei Zhao,Wei Zhou,Krina T. Zondervan,Jerome I. Rotter,John Andrew Pospisilik,Fernando Rivadeneira,Ingrid B. Borecki,Panos Deloukas,Panos Deloukas,Timothy M. Frayling,Guillaume Lettre,Kari E. North,Cecilia M. Lindgren,Joel N. Hirschhorn,Joel N. Hirschhorn,Ruth J. F. Loos +489 more
TL;DR: Exome-wide analysis identifies rare and low-frequency coding variants associated with body mass index that confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
Journal ArticleDOI
Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk
Oddgeir L. Holmen,He-Ming Zhang,Yanbo Fan,Daniel H. Hovelson,Ellen M. Schmidt,Wei-Wei Zhou,Yanhong Guo,Ji Zhang,Arnulf Langhammer,Maja-Lisa Løchen,Santhi K. Ganesh,Lars J. Vatten,Frank Skorpen,Håvard Dalen,Jifeng Zhang,Subramaniam Pennathur,Jin-jin Chen,Carl G. P. Platou,Ellisiv B. Mathiesen,Tom Wilsgaard,Inger Njølstad,Michael Boehnke,Y. Eugene Chen,Gonçalo R. Abecasis,Kristian Hveem,Cristen J. Willer +25 more
TL;DR: This study demonstrates that systematic assessment of coding variation can quickly point to a candidate causal gene within a locus previously known as NCAN-CILP2-PBX4 or 19p13.
Journal ArticleDOI
Population genetic differentiation of height and body mass index across Europe
Matthew R. Robinson,Gibran Hemani,Carolina Medina-Gomez,Massimo Mezzavilla,Tõnu Esko,Tõnu Esko,Tõnu Esko,Konstantin Shakhbazov,Joseph E. Powell,Anna A. E. Vinkhuyzen,Sonja I. Berndt,Stefan Gustafsson,Anne E. Justice,Bratati Kahali,Adam E. Locke,Tune H. Pers,Tune H. Pers,Tune H. Pers,Sailaja Vedantam,Sailaja Vedantam,Andrew R. Wood,Wouter van Rheenen,Ole A. Andreassen,Paolo Gasparini,Andres Metspalu,Leonard H. van den Berg,Jan H. Veldink,Fernando Rivadeneira,Thomas Werge,Thomas Werge,Gonçalo R. Abecasis,Dorret I. Boomsma,Dorret I. Boomsma,Daniel I. Chasman,Eco J. C. de Geus,Eco J. C. de Geus,Timothy M. Frayling,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Jouke-Jan Hottenga,Jouke-Jan Hottenga,Erik Ingelsson,Erik Ingelsson,Ruth J. F. Loos,Ruth J. F. Loos,Patrik K. E. Magnusson,Nicholas G. Martin,Grant W. Montgomery,Kari E. North,Kari E. North,Nancy L. Pedersen,Tim D. Spector,Elizabeth K. Speliotes,Michael E. Goddard,Michael E. Goddard,Jian Yang,Peter M. Visscher +57 more
TL;DR: It is found that many independent loci contribute to population genetic differences in height and body mass index in 9,416 individuals across 14 European countries.