G
Gonçalo R. Abecasis
Researcher at University of Michigan
Publications - 629
Citations - 271012
Gonçalo R. Abecasis is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 179, co-authored 595 publications receiving 230323 citations. Previous affiliations of Gonçalo R. Abecasis include Johns Hopkins University School of Medicine & Wellcome Trust Centre for Human Genetics.
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Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome
Henry Richard Johnston,Yi-Juan Hu,Jingjing Gao,Timothy D. O’Connor,Gonçalo R. Abecasis,Genevieve L. Wojcik,Christopher R. Gignoux,Pierre-Antoine Gourraud,Antoine Lizee,Mark Hansen,Rob Genuario,Dave Bullis,Cindy Lawley,Eimear E. Kenny,Carlos Bustamante,Terri H. Beaty,Rasika A. Mathias,Kathleen C. Barnes,Zhaohui S. Qin +18 more
TL;DR: This array is designed based on the novel variation identified in 642 CAAPA samples of African ancestry with high coverage whole genome sequence data, and will enable better GWAS analyses for researchers with individuals of African descent in their study populations.
Posted ContentDOI
Exploring Various Polygenic Risk Scores for Basal Cell Carcinoma, Cutaneous Squamous Cell Carcinoma and Melanoma in the Phenomes of the Michigan Genomics Initiative and the UK Biobank
Lars G. Fritsche,Lauren J. Beesley,Peter VandeHaar,Robert B. Peng,Maxwell Salvatore,Matthew Zawistowski,Sarah A Gagliano Taliun,Sayantan Das,Jonathon LeFaive,Erin O. Kaleba,Thomas T. Klumpner,Stephanie E. Moser,Victoria M. Blanc,Chad M. Brummett,Sachin Kheterpal,Gonçalo R. Abecasis,Stephen B. Gruber,Bhramar Mukherjee +17 more
TL;DR: This paper examines the three most common skin cancer subtypes in the USA and conducts a phenome-wide association study (PheWAS) within the MGI data to evaluate their association with secondary traits and develops a web platform called PRSweb that provides detailed P heWAS results and allows users to directly compare different PRS construction methods.
Posted ContentDOI
Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries
Alan Kwong,Thomas W. Blackwell,Jonathon LeFaive,Mariza de Andrade,John Barnard,Kathleen C. Barnes,John Blangero,Eric Boerwinkle,Esteban G. Burchard,Brian E. Cade,Daniel I. Chasman,Han Chen,Matthew P. Conomos,L. Adrienne Cupples,Patrick T. Ellinor,Celeste Eng,Yan Gao,Xiuqing Guo,Marguerite R. Irvin,Tanika N. Kelly,Wonji Kim,Charles Kooperberg,Steven A. Lubitz,Angel C.Y. Mak,Ani Manichaikul,Rasika A. Mathias,May E. Montasser,Courtney G. Montgomery,Solomon K. Musani,Nicholette D. Palmer,Gina M. Peloso,Dandi Qiao,Alexander P. Reiner,Dan M. Roden,M. Benjamin Shoemaker,Jennifer A. Smith,Nicholas L. Smith,Jessica Lasky-Su,Hemant K. Tiwari,Daniel E. Weeks,Scott T. Weiss,Laura J. Scott,Albert V. Smith,Gonçalo R. Abecasis,Michael Boehnke,Hyun Min Kang +45 more
TL;DR: This manuscript presents the Robust Unified Test for HWE (RUTH), a practical and scalable software tool to rapidly perform HWE tests across millions of markers and hundreds of thousands of individuals while supporting standard VCF/BCF formats, and demonstrates different tradeoffs between false positives and statistical power across the methods.
Posted ContentDOI
Association Analysis and Meta-Analysis of Multi-allelic Variants for Large Scale Sequence Data
Xiaowei Zhan,Sai Chen,Yu Jiang,Mengzhen Liu,William G. Iacono,John K. Hewitt,John E. Hokanson,Kenneth Krauter,Markku Laakso,Kevin Li,Sharon M. Lutz,Matt McGue,Anita Pandit,Gregory J.M. Zajac,Michael Boehnke,Gonçalo R. Abecasis,Bibo Jiang,Scott I. Vrieze,Dajiang J. Liu +18 more
TL;DR: The joint modeling approach provided an unbiased estimate of genetic effects, greatly improved the power of single variant association tests, and enhanced gene-level tests over existing approaches and was evaluated through extensive simulations and a large meta-analysis.
Genome-wide association analysis of psoriatic arthritis
Rajan P. Nair,Philip E. Stuart,LC Tsoi,Eva Ellinghaus,John P. Walsh,Chandran,Trilokraj Tejasvi,T Esko,Kristina Callis Duffin,Robert W. Ike,Anne M. Bowcock,J.J. Voorhees,Henry Lim,Michael Weichenthal,Andre Franke,Proton Rahman,Gerald G. Krueger,Gonçalo R. Abecasis,Dafna D. Gladman,James T. Elder +19 more