G
Gonçalo R. Abecasis
Researcher at University of Michigan
Publications - 629
Citations - 271012
Gonçalo R. Abecasis is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 179, co-authored 595 publications receiving 230323 citations. Previous affiliations of Gonçalo R. Abecasis include Johns Hopkins University School of Medicine & Wellcome Trust Centre for Human Genetics.
Papers
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Journal ArticleDOI
Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology
Satria Sajuthi,Jamie L. Everman,Nathan D. Jackson,Benjamin Saef,Cydney Rios,Camille M. Moore,Angel C.Y. Mak,Celeste Eng,A. Fairbanks-Mahnke,Sandra Salazar,Jennifer R. Elhawary,Scott Huntsman,Vivian Medina,Deborah A. Nickerson,Soren Germer,Michael C. Zody,Gonçalo R. Abecasis,Hyun Min Kang,Kenneth Rice,Rajesh Kumar,Noah Zaitlen,Sam S. Oh,Jose R. Rodriguez-Santana,Esteban G. Burchard,Max A. Seibold +24 more
TL;DR: The authors performed a transcriptome-wide association study for asthma by combining RNA-seq data from the nasal airway epithelium of 681 children, with UK Biobank genetic association data.
Journal ArticleDOI
AbCD: arbitrary coverage design for sequencing-based genetic studies
TL;DR: AbCD (arbitrary coverage design) is a user-friendly interface providing pre-estimated effective sample sizes, specific to each minor allele frequency category, for designs with arbitrary coverage and sample size and for four major ethnic groups (Europeans, Africans, Asians and African Americans).
Posted ContentDOI
Genome-wide association study of 1 million people identifies 111 loci for atrial fibrillation
Jonas B. Nielsen,Rosa B. Thorolfsdottir,Lars G. Fritsche,Weichen Zhou,Morten W. Skov,Sarah E. Graham,Todd J. Herron,Shane McCarthy,Ellen M. Schmidt,Gardar Sveinbjornsson,Ida Surakka,Michael R. Mathis,Masatoshi Yamazaki,Ryan D. Crawford,Maiken Elvestad Gabrielsen,Anne Heidi Skogholt,Oddgeir L. Holmen,Maoxuan Lin,Brooke N. Wolford,Rounak Dey,Håvard Dalen,Håvard Dalen,Patrick Sulem,Jonathan H. Chung,Joshua D. Backman,David O. Arnar,Unnur Thorsteinsdottir,Aris Baras,Colm O'Dushlaine,Anders G. Holst,Xiaoquan Wen,Whitney E. Hornsby,Frederick E. Dewey,Michael Boehnke,Sachin Kheterpal,Seunggeun Lee,Hyun Min Kang,Hilma Holm,Jacob O. Kitzman,Jordan A. Shavit,José Jalife,Chad M. Brummett,Tanya M. Teslovich,David J. Carey,Daniel F. Gudbjartsson,Kari Stefansson,Gonçalo R. Abecasis,Kristian Hveem,Cristen J. Willer +48 more
TL;DR: Experiments in rabbits with heart failure and left atrial dilation identified a heterogeneous distributed molecular switch from MYH6 to MYH7 in the left atrium, which resulted in contractile and functional heterogeneity and may predispose to initiation and maintenance of atrial arrhythmia.
Journal ArticleDOI
Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program
Brian E. Cade,Brian E. Cade,Brian E. Cade,Jiwon Lee,Tamar Sofer,Tamar Sofer,Heming Wang,Heming Wang,Heming Wang,Man Zhang,Han Chen,Sina A. Gharib,Daniel J. Gottlieb,Daniel J. Gottlieb,Daniel J. Gottlieb,Xiuqing Guo,Jacqueline M. Lane,Jingjing Liang,Xihong Lin,Hao Mei,Sanjay R. Patel,Shaun Purcell,Shaun Purcell,Shaun Purcell,Richa Saxena,Neomi A. Shah,Daniel S. Evans,Craig L. Hanis,David R. Hillman,Sutapa Mukherjee,Lyle J. Palmer,Katie L. Stone,Gregory J. Tranah,Gonçalo R. Abecasis,Eric Boerwinkle,Eric Boerwinkle,Adolfo Correa,L. Adrienne Cupples,Robert C. Kaplan,Deborah A. Nickerson,Kari E. North,Bruce M. Psaty,Bruce M. Psaty,Jerome I. Rotter,Stephen S. Rich,Russell P. Tracy,Ramachandran S. Vasan,James G. Wilson,Xiaofeng Zhu,Susan Redline,Susan Redline,Susan Redline +51 more
TL;DR: The first whole-genome sequence analysis of SDB highlighted associations in genes that modulate lung development, inflammation, respiratory rhythmogenesis and HIF1A-mediated hypoxic response.
Journal ArticleDOI
Enrichment of colorectal cancer associations in functional regions: Insight for using epigenomics data in the analysis of whole genome sequence-imputed GWAS data.
Stephanie A. Bien,Paul L. Auer,Tabitha A. Harrison,Conghui Qu,Charles M. Connolly,Peyton Greenside,Sai Chen,Sonja I. Berndt,Stéphane Bézieau,Hyun Min Kang,Jeroen R. Huyghe,Hermann Brenner,Graham Casey,Andrew T. Chan,John L. Hopper,Barbara L. Banbury,Jenny Chang-Claude,Stephen J. Chanock,Robert W. Haile,Michael Hoffmeister,Christian Fuchsberger,Mark A. Jenkins,Suzanne M. Leal,Mathieu Lemire,Polly A. Newcomb,Steven Gallinger,John D. Potter,Robert E. Schoen,Martha L. Slattery,Joshua D. Smith,Loic Le Marchand,Emily White,Brent W. Zanke,Gonçalo R. Abecasis,Christopher S. Carlson,Ulrike Peters,Deborah A. Nickerson,Anshul Kundaje,Li Hsu,Ccfr +39 more
TL;DR: Although distance-based aggregation of less frequent variants in CR ARE surrounding TSS showed modest enrichment, future association studies would likely benefit from joint analysis of transcriptomes and epigenomes to better link regulatory variation with target genes.