K
K. Ligon
Researcher at Georgia Regents University
Publications - 4
Citations - 199
K. Ligon is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Pramipexole & LRRK2. The author has an hindex of 4, co-authored 4 publications receiving 184 citations.
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Journal ArticleDOI
Long-term outcome of early versus delayed rasagiline treatment in early Parkinson's disease.
Robert A. Hauser,Mark F. Lew,Howard I. Hurtig,William G. Ondo,Joanne Wojcieszek,Cheryl Fitzer-Attas,Frederick J. Marshall,Irenita Gardiner,Nancy Pearson,Debra Berry,Kathleen M. Shannon,Jean A. Jaglin,William G. Ondo,Christine Hunter,Cathy R. Anderson,Peter A. LeWitt,Patricia Kaminski,Dawn Miller,Maryan DeAngelis,Janis M. Miyasaki,Julie So,Lisa Johnston,Caroline M. Tanner,Tracy Stewart,Lisa Tagg,Sheila Everett,Georgia Germain,Mickie Welsh,Micki McCollister,Linda L. Mann,Carlos Singer,William C. Koller,William J. Weiner,Dinorah Bateman,Tilak Mendis,Melodie Moterson,Cynthia Alcorn-Costa,Keely Haas,Peggy Gray,Davoud Mohtat,Neila Mendis,Laura Sutherland,Howard H. Hurtig,Mary Lloyd,Mary Mathews,Robert Hauser,Lisa Gauger,Patricia Dyches,Cheryl Newcomb,Jean P. Hubble,Karen Betcher,Carolyn C. Weeks,Sandra K. Kostyk,Ali H. Rajput,Marlene Gerow,Linda Klassen,Marianne Ewasnishin,Lawrence I. Golb,Vanessa Patterson,Deborah L. Caputo,Patricia Seuffert,Rajesh Pahwa,Tamara Gales,Lorette J. Jenkins,Amy Parsons,Scott Cradr,Jovianna N. Wellinghoff,Shantelle Coe,Cheryl Armstrong,Connie Kawai,Katherine B. Hawthorne,Kellie Gelles,Xiaoming Lu,Suzanne W. Schuman,Cheryl Cooper,Kenneth Marek,Barbara Fussell,Karen Caplan,Erica Barnabei,Karen Stavris,Kapil D. Sethi,J. Carpenter,James B. Osborne,Shoba Narayan,K. Ligon,Eric Molho,Sharon Evans,Jacqueline Nash,Diane Brown,Mark Stacy,Kelli Williamson,Peter Novak,Robert G. Feldman,Cathi A. Thomas,W.R. Wayne Martin,Pam King,Germanine McInnes,Shaunna Caouette,Jo Belden,Andew Feigin,Jean Ayan,Barbara Shannon,Charles H. Adler,Stephanie Newman,Teri Radam,Myrna Schear,Naomi Santoni,Sharon Wortzel,Nancy Saton,Paul J. Tuite,Susan Rolandelli,Jody Lowery,Brenda Ebbitt,Adrienne Baranauskas,Michael J. Aminoff,Mirann DiMinno,Jessie Roth,Tracey Borst,Julie Hevezi,Carolyn Deloa,Tracey Tam,Anita Lopez,John M. Bertoni,Larisa I. Skrypnik,Carolyn Peterson,Mark Forrest Gordon,Roberta Winnick,Sharyn Parness,Joanne Hamann,Vincent Calabrese,Peggy Roberge,Paul Atchison,Cathy W. Allen,Susan Rolli,Arif Dalvi,Un Jung Kang,Judy Richman,Shirley Uy +137 more
TL;DR: Compared to delayed start, early initiation of rasagiline provided long‐term clinical benefit, even in the face of treatment with other dopaminergic agents.
Journal ArticleDOI
Pramipexole in levodopa-treated Parkinson disease patients of African, Asian, and Hispanic heritage
Caroline M. Tanner,Cynthia L. Comella,Cornelia Kamp,Karl Kieburtz,David Oakes,Frederick J. Marshall,Denni Day,Julie H. Carter,Rajesh Pahwa,Ira Shoulson,Daniel Truong,An Hao Tran,Karen Thompson,Lisa M. Shulman,Dinorah Rodriguez,Mariella Fernandez,Carmen Serrano Ramos,Adelma Rivera Cruz,Giselle Petzinger,Sheila Everett,Jayaraman Rao,Clare Das,Kapil D. Sethi,K. Ligon,Cheryl H. Waters,Mickie Welsh,Andrew Feigin,Joel S. Perlmutter,Lori McGee-Minnich,Kenneth Marek,Susan Broshjeit,Janet S. Cellar,Howard I. Hurtig,Mary Matthews,Kathleen M. Shannon,Kimberly Janko,George W. Paulson,Carolyn C. Weeks,Carson Reider,Richard Trosch,Kathie Mistura,William C. Koller,Marian L. Evatt,C.D. Wood,Ronald F. Pfeiffer,Sara Rast,Brenda Pfeiffer,Alicia Brocht,Cindy Casaceli,Andrea Freimuth,Karen Hodgeman,Arthur Watts,Sam Goldman +52 more
TL;DR: Tolerability and safety overall were similar among the groups, but differences in profiles of adverse effects and tolerability were suggested.
Journal ArticleDOI
Mutations in LRRK2 other than G2019S are rare in a north-American based sample of familial Parkinson's didease
Nathan Pankratz,Michael W. Pauciulo,V. E. Elsaesser,Diane K. Marek,Cheyl A. Halter,Alice Rudolph,Clifford W. Shults,Clifford W. Shults,Tatiana Foroud,William C. Nichols,William C. Nichols,Cliff Shults,Frederick J. Marshall,David Oakes,Aileen Shinaman,Karen Marder,P. M. Conneally,Kelly E. Lyons,Eric Siemers,Stewart A. Factor,Donald S. Higgins,Sharon Evans,H. Shill,M. Stacy,J. Danielson,L. Marlor,K. Williamson,Joseph Jankovic,Christine Hunter,David Simon,P. Ryan,Lisa Scollins,Rachel Saunders-Pullman,Karyn Boyar,C. Costan-Toth,E. Ohmann,Lewis Sudarsky,C. Joubert,Joseph H. Friedman,Kelvin L. Chou,Hubert H. Fernandez,Margaret C. Lannon,Nestor Galvez-Jimenez,A. Podichetty,Peter A. LeWitt,Maryan DeAngelis,Christopher F. O'Brien,Lauren Seeberger,C. Dingmann,Deborah Judd,J. Fraser,Juliette Harris,John M. Bertoni,Carolyn Peterson,S. Chouinard,Michel Panisset,Michel Panisset,Jean Hall,Jean Hall,H. Poiffaut,Vincent Calabrese,Peggy Roberge,Joanne Wojcieszek,Joann Belden,Cheryl Halter,Danna Jennings,Kenneth Marek,Susan Mendick,Stephen G. Reich,Becky Dunlop,Mandar Jog,C. Horn,Jayaraman Rao,Maureen Cook,Ryan J. Uitti,Margaret F. Turk,T. Ajax,J. Mannetter,Kapil D. Sethi,J. Carpenter,K. Ligon,S. Narayan,L. Woodward,Karen Blindauer,Jeannine Petit,L. Elmer,E. Aiken,Kathy Davis,C. Schell,S. Wilson,Miodrag Velickovic,William C. Koller,S. Phipps,Andrew Feigin,Mark Forrest Gordon,Joanna Hamann,E. Licari,M. Marotta-Kollarus,Barbara Shannon,Roberta Winnick,Tatyana Simuni,A. Kaczmarek,Karen Williams +102 more
TL;DR: Although the G2019S mutation remains the most common mutation identified in familial PD patients, other mutations in LRRK2 are infrequent and only 1 of the 12 newly screened mutations, R1441C, was detected in a single family in the patient cohort.
Journal ArticleDOI
R1514Q substitution in Lrrk2 is not a pathogenic Parkinson's disease mutation
William C. Nichols,William C. Nichols,Diane K. Marek,Michael W. Pauciulo,Nathan Pankratz,Cheryl Halter,Alice Rudolph,Clifford W. Shults,Clifford W. Shults,Joanne Wojcieszek,Tatiana Foroud,Cliff Shults,Frederick J. Marshall,David Oakes,Anja Rudolph,Aileen Shinaman,Karen Marder,P. M. Conneally,T. Foroud,C. Halter,Kelly E. Lyons,Eric Siemers,Stewart A. Factor,Donald S. Higgins,Sharon Evans,Holly A. Shill,Mark Stacy,J. Danielson,Lynn Marlor,Kelli Williamson,Joseph Jankovic,Christine Hunter,David Simon,P. Ryan,Lisa Scollins,Rachel Saunders-Pullman,Karyn Boyar,C. Costan-Toth,E. Ohmann,Lewis Sudarsky,C. Joubert,Joseph H. Friedman,Kelvin L. Chou,Hubert H. Fernandez,Margaret C. Lannon,Nestor Galvez-Jimenez,A. Podichetty,Peter A LeWitt,Maryan DeAngelis,Christopher F. O'Brien,Lauren Seeberger,C. Dingmann,Deborah Judd,J. Fraser,Juliette Harris,John M. Bertoni,Carolyn Peterson,S. Chouinard,M. Panisset,J. Hall,H. Poiffaut,Vincent Calabrese,Peggy Roberge,J. Wojcieszek,Joann Belden,Danna Jennings,Kenneth Marek,Susan Mendick,Stephen G. Reich,Becky Dunlop,Mandar Jog,C. Horn,Jayaraman Rao,Maureen Cook,Ryan J. Uitti,Margaret F. Turk,T. Ajax,J. Mannetter,Kapil D. Sethi,J. Carpenter,K. Ligon,S. Narayan,L. Woodward,Karen Blindauer,Jeannine Petit,L. Elmer,E. Aiken,Kathy Davis,C. Schell,S. Wilson,Miodrag Velickovic,William C. Koller,S. Phipps,Andrew Feigin,Marc L. Gordon,Joanna Hamann,E. Licari,M. Marotta-Kollarus,Barbara Shannon,Roberta Winnick,Tanya Simuni,A. Kaczmarek,Karen Williams,M. Wolff,Magali Fernandez,Jean P. Hubble,Sandra K. Kostyk,A. Campbell,Carson Reider,Richard Camicioli,Julie H. Carter,Pam Andrews,S. Morehouse,C. Stone,Tilak Mendis,David Grimes,Peggy Gray,K. Haas,James Sutton,B. Hutchinson,Joan Young,A. H. Rajput,L. Klassen,T. Shirley,Bala V. Manyam,Patricia Simpson,J. Whetteckey,Brian Wulbrecht,Daniel D. Truong,Mayank Pathak,N. Luong,T. Tra,An Tran,J. Vo,Anthony E. Lang,Galit Kleiner-Fisman,Anette Nieves,Julie So,G. Podskalny,L. Giffin,Paul Atchison,C. Allen,W.R. Wayne Martin,Marguerite Wieler,Oksana Suchowersky,Mary Lou Klimek,Neal Hermanowicz,Shari Niswonger,Deborah Fontaine,Michael J. Aminoff,Chad W. Christine,Mariann DiMinno,J. Hevezi,Arif Dalvi,Un Jung Kang,Judy Richman,Shirley Uy,Alok Sahay,Donna Schwieterman,Maureen A. Leehey,S. Culver,Theresa Derian,T. Demarcaida,S. Belber,Robert L. Rodnitzky,Judith Dobson,Rajesh Pahwa,T. Gales,Stephanie Thomas,L. Shulman,W. Weiner,K. Dustin,Carlos Singer,L. Zelaya,Paul J. Tuite,V. Hagen,Susan Rolandelli,Robyn Schacherer,Paul Gordon,Joan Werner,Carmen Serrano,Sandra Roque,R. Kurlan,Debra Berry,Irenita Gardiner,Robert A. Hauser,Juan Sanchez-Ramos,Theresa A. Zesiewicz,Holly Delgado,K. Price,P. Rodriguez,Ronald F. Pfeiffer,L. Davis,Brenda Pfeiffer,Richard B. Dewey,B. Hayward,M. Meacham,Francis O. Walker,Vicki Hunt,Brad A. Racette,L. Good,M. Rundle,Arthur Watts,A. Wang,Tori Ross,Susan Bennett,D. Kamp,E. Julian-Baros +207 more
TL;DR: Data suggest that the R1514Q variant is not a pathogenic LRRK2 mutation, and it is imperative that the causative nature of any newly identified genetic variant be determined before it is included in any panel for diagnostic testing.