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Shirley Uy
Researcher at University of Chicago
Publications - 4
Citations - 509
Shirley Uy is an academic researcher from University of Chicago. The author has contributed to research in topics: Parkin & Age of onset. The author has an hindex of 4, co-authored 4 publications receiving 490 citations.
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Journal ArticleDOI
Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease
Tatiana Foroud,Sean K. Uniacke,L. Liu,Nathan Pankratz,Anja Rudolph,Cheryl Halter,Clifford W. Shults,Karen Marder,P. M. Conneally,William C. Nichols,Lawrence I. Golbe,William C. Koller,Kelly E. Lyons,Frederick J. Marshall,David Oakes,Aileen Shinaman,Eric Siemers,Joanne Wojcieszek,Joann Belden,Julie H. Carter,Richard Camicioli,Pamela Andrews,Magali Fernandez,Jean P. Hubble,Carson Reider,Ali H. Rajput,Alex Rajput,Theresa Shirley,Michael Panisset,Jean Hall,Tilak Mendis,David Grimes,Peggy Gray,Carmen Serrano Ramos,Sandra Roque,Stephen G. Reich,Becky Dunlop,Robert A. Hauser,Juan Sanchez-Ramos,Theresa A. Zesiewicz,Holly Delgado,Joseph H. Friedman,Hubert H. Fernandez,Margaret C. Lannon,Lauren Seeberger,Christopher F. O'Brien,Deborah Judd,Lawrence Elmer,Kathy Davis,Deborah Fontaine,Ronald F. Pfeiffer,Brenda Pfeiffer,Michael J. Aminoff,Mariann DiMinno,Daniel D. Truong,Mayank Pathak,Anhoa Tran,Robert L. Rodnitzky,Judith Dobson,Rajesh Pahwa,Stephanie Thomas,Danna Jennings,Kenneth Marek,Susan Mendick,Juliette Harris,William J. Weiner,Roger Kurlan,Debra Berry,Peter A. LeWitt,Maryan DeAngelis,Paul J. Tuite,Robyn Schacherer,W.R. Wayne Martin,Marguerite Wieler,Bala V. Manyam,Patricia Simpson,John M. Bertoni,Carolyn Peterson,Mark Forrest Gordon,Joanna Hamann,Joseph Jankovic,Christine Hunter,Stewart A. Factor,Sharon Evans,Anette Nieves,Julie So,Mark Stacy,Kelli Williamson,Francis O. Walker,Victoria Hunt,Un Jung Kang,Shirley Uy,Karen Bindauer,Jeannine Petit,David Simon,Lisa Scollins,Rachel Saunders Pullman,Karyn Boyer,Paul Gordon +98 more
TL;DR: Mutations in the parkin gene occur among individuals with PD with an older age at onset (≥60 years) who have a positive family history of the disease, and the clinical findings of parkin-positive individuals are remarkably similar to those without mutations.
Journal ArticleDOI
Significant Linkage of Parkinson Disease to Chromosome 2q36-37
Nathan Pankratz,William C. Nichols,Sean K. Uniacke,Cheryl Halter,Alice Rudolph,Cliff Shults,Cliff Shults,P. Michael Conneally,Tatiana Foroud,Lawrence I. Golbe,William C. Koller,Kelly E. Lyons,Karen Marder,Frederick J. Marshall,David Oakes,Aileen Shinaman,Eric Siemers,Joanne Wojcieszek,Joann Belden,Julie H. Carter,Richard Camicioli,Pamela Andrews,Magali Fernandez,Jean P. Hubble,Carson Reider,Ali H. Rajput,Alex Rajput,Theresa Shirley,Michel Panisset,Jean Hall,Tilak Mendis,David Grimes,Peggy Gray,Carmen Serrano Ramos,Sandra Roque,Stephen G. Reich,Becky Dunlop,Robert A. Hauser,Juan Sanchez-Ramos,Theresa A. Zesiewicz,Holly Delgado,Joseph H. Friedman,Hubert H. Fernandez,Margaret C. Lannon,Lauren Seeberger,Christopher F. O'Brien,Deborah Judd,Lawrence Elmer,Kathy Davis,Deborah Fontaine,Ronald F. Pfeiffer,Brenda Pfeiffer,Michael J. Aminoff,Mariann DiMinno,Daniel D. Truong,Mayank Pathak,Anhoa Tran,Robert L. Rodnitzky,Judith Dobson,Rajesh Pahwa,Stephanie Thomas,Danna Jennings,Kenneth Marek,Susan Mendick,Juliette Harris,William J. Weiner,Roger Kurlan,Debra Berry,Peter A. LeWitt,Maryan DeAngelis,Paul J. Tuite,Robyn Schacherer,W.R. Wayne Martin,Marguerite Wieler,Bala V. Manyam,Patricia Simpson,John M. Bertoni,Carolyn Peterson,Mark Forrest Gordon,Joanna Hamann,Joseph Jankovic,Christine Hunter,Stewart A. Factor,Sharon Evans,Anette Nieves,Julie So,Mark Stacy,Kelli Williamson,Francis O. Walker,Victoria Hunt,Un Jung Kang,Shirley Uy,Karen Blindauer,Jeannine Petit,David Simon,Lisa Scollins,Rachel Saunders Pullman,Karyn Boyar,Paul Gordon,Joan Werner +99 more
TL;DR: This work has expanded the sample to include 150 families meeting the strictest diagnostic definition of verified PD, and performs analyses using only those pedigrees with the strongest family history of PD, which strongly suggests that variation in a gene on chromosome 2q36-37 contributes to PD susceptibility.
Journal ArticleDOI
Long-term outcome of early versus delayed rasagiline treatment in early Parkinson's disease.
Robert A. Hauser,Mark F. Lew,Howard I. Hurtig,William G. Ondo,Joanne Wojcieszek,Cheryl Fitzer-Attas,Frederick J. Marshall,Irenita Gardiner,Nancy Pearson,Debra Berry,Kathleen M. Shannon,Jean A. Jaglin,William G. Ondo,Christine Hunter,Cathy R. Anderson,Peter A. LeWitt,Patricia Kaminski,Dawn Miller,Maryan DeAngelis,Janis M. Miyasaki,Julie So,Lisa Johnston,Caroline M. Tanner,Tracy Stewart,Lisa Tagg,Sheila Everett,Georgia Germain,Mickie Welsh,Micki McCollister,Linda L. Mann,Carlos Singer,William C. Koller,William J. Weiner,Dinorah Bateman,Tilak Mendis,Melodie Moterson,Cynthia Alcorn-Costa,Keely Haas,Peggy Gray,Davoud Mohtat,Neila Mendis,Laura Sutherland,Howard H. Hurtig,Mary Lloyd,Mary Mathews,Robert Hauser,Lisa Gauger,Patricia Dyches,Cheryl Newcomb,Jean P. Hubble,Karen Betcher,Carolyn C. Weeks,Sandra K. Kostyk,Ali H. Rajput,Marlene Gerow,Linda Klassen,Marianne Ewasnishin,Lawrence I. Golb,Vanessa Patterson,Deborah L. Caputo,Patricia Seuffert,Rajesh Pahwa,Tamara Gales,Lorette J. Jenkins,Amy Parsons,Scott Cradr,Jovianna N. Wellinghoff,Shantelle Coe,Cheryl Armstrong,Connie Kawai,Katherine B. Hawthorne,Kellie Gelles,Xiaoming Lu,Suzanne W. Schuman,Cheryl Cooper,Kenneth Marek,Barbara Fussell,Karen Caplan,Erica Barnabei,Karen Stavris,Kapil D. Sethi,J. Carpenter,James B. Osborne,Shoba Narayan,K. Ligon,Eric Molho,Sharon Evans,Jacqueline Nash,Diane Brown,Mark Stacy,Kelli Williamson,Peter Novak,Robert G. Feldman,Cathi A. Thomas,W.R. Wayne Martin,Pam King,Germanine McInnes,Shaunna Caouette,Jo Belden,Andew Feigin,Jean Ayan,Barbara Shannon,Charles H. Adler,Stephanie Newman,Teri Radam,Myrna Schear,Naomi Santoni,Sharon Wortzel,Nancy Saton,Paul J. Tuite,Susan Rolandelli,Jody Lowery,Brenda Ebbitt,Adrienne Baranauskas,Michael J. Aminoff,Mirann DiMinno,Jessie Roth,Tracey Borst,Julie Hevezi,Carolyn Deloa,Tracey Tam,Anita Lopez,John M. Bertoni,Larisa I. Skrypnik,Carolyn Peterson,Mark Forrest Gordon,Roberta Winnick,Sharyn Parness,Joanne Hamann,Vincent Calabrese,Peggy Roberge,Paul Atchison,Cathy W. Allen,Susan Rolli,Arif Dalvi,Un Jung Kang,Judy Richman,Shirley Uy +137 more
TL;DR: Compared to delayed start, early initiation of rasagiline provided long‐term clinical benefit, even in the face of treatment with other dopaminergic agents.
Journal ArticleDOI
R1514Q substitution in Lrrk2 is not a pathogenic Parkinson's disease mutation
William C. Nichols,William C. Nichols,Diane K. Marek,Michael W. Pauciulo,Nathan Pankratz,Cheryl Halter,Alice Rudolph,Clifford W. Shults,Clifford W. Shults,Joanne Wojcieszek,Tatiana Foroud,Cliff Shults,Frederick J. Marshall,David Oakes,Anja Rudolph,Aileen Shinaman,Karen Marder,P. M. Conneally,T. Foroud,C. Halter,Kelly E. Lyons,Eric Siemers,Stewart A. Factor,Donald S. Higgins,Sharon Evans,Holly A. Shill,Mark Stacy,J. Danielson,Lynn Marlor,Kelli Williamson,Joseph Jankovic,Christine Hunter,David Simon,P. Ryan,Lisa Scollins,Rachel Saunders-Pullman,Karyn Boyar,C. Costan-Toth,E. Ohmann,Lewis Sudarsky,C. Joubert,Joseph H. Friedman,Kelvin L. Chou,Hubert H. Fernandez,Margaret C. Lannon,Nestor Galvez-Jimenez,A. Podichetty,Peter A LeWitt,Maryan DeAngelis,Christopher F. O'Brien,Lauren Seeberger,C. Dingmann,Deborah Judd,J. Fraser,Juliette Harris,John M. Bertoni,Carolyn Peterson,S. Chouinard,M. Panisset,J. Hall,H. Poiffaut,Vincent Calabrese,Peggy Roberge,J. Wojcieszek,Joann Belden,Danna Jennings,Kenneth Marek,Susan Mendick,Stephen G. Reich,Becky Dunlop,Mandar Jog,C. Horn,Jayaraman Rao,Maureen Cook,Ryan J. Uitti,Margaret F. Turk,T. Ajax,J. Mannetter,Kapil D. Sethi,J. Carpenter,K. Ligon,S. Narayan,L. Woodward,Karen Blindauer,Jeannine Petit,L. Elmer,E. Aiken,Kathy Davis,C. Schell,S. Wilson,Miodrag Velickovic,William C. Koller,S. Phipps,Andrew Feigin,Marc L. Gordon,Joanna Hamann,E. Licari,M. Marotta-Kollarus,Barbara Shannon,Roberta Winnick,Tanya Simuni,A. Kaczmarek,Karen Williams,M. Wolff,Magali Fernandez,Jean P. Hubble,Sandra K. Kostyk,A. Campbell,Carson Reider,Richard Camicioli,Julie H. Carter,Pam Andrews,S. Morehouse,C. Stone,Tilak Mendis,David Grimes,Peggy Gray,K. Haas,James Sutton,B. Hutchinson,Joan Young,A. H. Rajput,L. Klassen,T. Shirley,Bala V. Manyam,Patricia Simpson,J. Whetteckey,Brian Wulbrecht,Daniel D. Truong,Mayank Pathak,N. Luong,T. Tra,An Tran,J. Vo,Anthony E. Lang,Galit Kleiner-Fisman,Anette Nieves,Julie So,G. Podskalny,L. Giffin,Paul Atchison,C. Allen,W.R. Wayne Martin,Marguerite Wieler,Oksana Suchowersky,Mary Lou Klimek,Neal Hermanowicz,Shari Niswonger,Deborah Fontaine,Michael J. Aminoff,Chad W. Christine,Mariann DiMinno,J. Hevezi,Arif Dalvi,Un Jung Kang,Judy Richman,Shirley Uy,Alok Sahay,Donna Schwieterman,Maureen A. Leehey,S. Culver,Theresa Derian,T. Demarcaida,S. Belber,Robert L. Rodnitzky,Judith Dobson,Rajesh Pahwa,T. Gales,Stephanie Thomas,L. Shulman,W. Weiner,K. Dustin,Carlos Singer,L. Zelaya,Paul J. Tuite,V. Hagen,Susan Rolandelli,Robyn Schacherer,Paul Gordon,Joan Werner,Carmen Serrano,Sandra Roque,R. Kurlan,Debra Berry,Irenita Gardiner,Robert A. Hauser,Juan Sanchez-Ramos,Theresa A. Zesiewicz,Holly Delgado,K. Price,P. Rodriguez,Ronald F. Pfeiffer,L. Davis,Brenda Pfeiffer,Richard B. Dewey,B. Hayward,M. Meacham,Francis O. Walker,Vicki Hunt,Brad A. Racette,L. Good,M. Rundle,Arthur Watts,A. Wang,Tori Ross,Susan Bennett,D. Kamp,E. Julian-Baros +207 more
TL;DR: Data suggest that the R1514Q variant is not a pathogenic LRRK2 mutation, and it is imperative that the causative nature of any newly identified genetic variant be determined before it is included in any panel for diagnostic testing.