J
Julie So
Researcher at University Health Network
Publications - 8
Citations - 1051
Julie So is an academic researcher from University Health Network. The author has contributed to research in topics: Age of onset & Genetic linkage. The author has an hindex of 8, co-authored 8 publications receiving 980 citations. Previous affiliations of Julie So include University of Toronto & Toronto Western Hospital.
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Journal ArticleDOI
A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease: No Evidence of Benefit
M. Flint Beal,David Oakes,Ira Shoulson,Claire Henchcliffe,Wendy R. Galpern,Richard H. Haas,Jorge L. Juncos,John G. Nutt,Tiffini Voss,Bernard Ravina,Clifford M Shults,Karen Helles,Victoria Snively,Mark F. Lew,Brian Griebner,Arthur Watts,Shan Gao,Emmanuelle Pourcher,Louisette Bond,Katie Kompoliti,Pinky Agarwal,Cherissa Sia,Mandar Jog,Linda Cole,Munira Sultana,Roger Kurlan,Irene H. Richard,Cheryl Deeley,Cheryl Waters,Angel Figueroa,Ani Arkun,Matthew Brodsky,William G. Ondo,Christine Hunter,Joohi Jimenez-Shahed,Alicia Palao,Janis M. Miyasaki,Julie So,James W. Tetrud,Liza Reys,Katharine Smith,Carlos Singer,Anita Blenke,David S. Russell,Candace Cotto,Joseph H. Friedman,Margaret C. Lannon,Lin Zhang,Edward Drasby,Rajeev Kumar,Thyagarajan Subramanian,Donna Stuppy Ford,David Grimes,Diane Cote,Jennifer Conway,Andrew Siderowf,Marian L. Evatt,Barbara Sommerfeld,Abraham Lieberman,Michael S. Okun,Ramon L. Rodriguez,Stacy Merritt,Camille Swartz,W.R. Wayne Martin,Pamela King,Natividad Stover,Stephanie Guthrie,Ray L. Watts,Anwar Ahmed,Hubert H. Fernandez,Adrienna Winters,Zoltan Mari,Ted M. Dawson,Becky Dunlop,Andrew Feigin,Barbara Shannon,Melissa J. Nirenberg,Mattson Ogg,Samuel A. Ellias,Cathi-Ann Thomas,Karen Frei,Ivan Bodis-Wollner,Sofya Glazman,Thomas Mayer,Robert A. Hauser,Rajesh Pahwa,April Langhammer,Ranjit Ranawaya,Lorelei Derwent,Kapil D. Sethi,Buff Farrow,Rajan Prakash,Irene Litvan,Annette Robinson,Alok Sahay,Maureen Gartner,Vanessa K. Hinson,Samuel Markind,Melisa Pelikan,Joel S. Perlmutter,Johanna M Hartlein,Eric Molho,Sharon Evans,Charles H. Adler,Amy Duffy,Marlene Lind,Lawrence Elmer,Kathy Davis,Julia Spears,Stephanie Wilson,Maureen A. Leehey,Neal Hermanowicz,Shari Niswonger,Holly A. Shill,Sanja Obradov,Alex Rajput,Marilyn Cowper,Stephanie Lessig,David D. Song,Deborah Fontaine,Cindy Zadikoff,Karen Williams,Karen Blindauer,Jo Bergholte,Clara Schindler Propsom,Mark Stacy,Joanne Field,Dragos Mihaila,Mark Chilton,Ergun Y. Uc,Jeri Sieren,David Simon,Lauren Kraics,Althea Silver,James T. Boyd,Robert W. Hamill,Christopher T. Ingvoldstad,Jennifer Young,Karen Thomas,Sandra K. Kostyk,Joanne Wojcieszek,Ronald F. Pfeiffer,Michel Panisset,Monica Beland,Stephen G. Reich,Michelle Cines,Nancy Zappala,Jean Rivest,Richard M. Zweig,L Pepper Lumina,Colette Lynn Hilliard,Stephen Grill,Marye Kellermann,Paul J. Tuite,Susan Rolandelli,Un Jung Kang,Joan Young,Jayaraman Rao,Maureen Cook,Lawrence Severt,Karyn Boyar +160 more
TL;DR: Coenzyme Q10 was safe and well tolerated in this population, but showed no evidence of clinical benefit, and the study was terminated after a prespecified futility criterion was reached.
Journal ArticleDOI
Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease
Tatiana Foroud,Sean K. Uniacke,L. Liu,Nathan Pankratz,Anja Rudolph,Cheryl Halter,Clifford W. Shults,Karen Marder,P. M. Conneally,William C. Nichols,Lawrence I. Golbe,William C. Koller,Kelly E. Lyons,Frederick J. Marshall,David Oakes,Aileen Shinaman,Eric Siemers,Joanne Wojcieszek,Joann Belden,Julie H. Carter,Richard Camicioli,Pamela Andrews,Magali Fernandez,Jean P. Hubble,Carson Reider,Ali H. Rajput,Alex Rajput,Theresa Shirley,Michael Panisset,Jean Hall,Tilak Mendis,David Grimes,Peggy Gray,Carmen Serrano Ramos,Sandra Roque,Stephen G. Reich,Becky Dunlop,Robert A. Hauser,Juan Sanchez-Ramos,Theresa A. Zesiewicz,Holly Delgado,Joseph H. Friedman,Hubert H. Fernandez,Margaret C. Lannon,Lauren Seeberger,Christopher F. O'Brien,Deborah Judd,Lawrence Elmer,Kathy Davis,Deborah Fontaine,Ronald F. Pfeiffer,Brenda Pfeiffer,Michael J. Aminoff,Mariann DiMinno,Daniel D. Truong,Mayank Pathak,Anhoa Tran,Robert L. Rodnitzky,Judith Dobson,Rajesh Pahwa,Stephanie Thomas,Danna Jennings,Kenneth Marek,Susan Mendick,Juliette Harris,William J. Weiner,Roger Kurlan,Debra Berry,Peter A. LeWitt,Maryan DeAngelis,Paul J. Tuite,Robyn Schacherer,W.R. Wayne Martin,Marguerite Wieler,Bala V. Manyam,Patricia Simpson,John M. Bertoni,Carolyn Peterson,Mark Forrest Gordon,Joanna Hamann,Joseph Jankovic,Christine Hunter,Stewart A. Factor,Sharon Evans,Anette Nieves,Julie So,Mark Stacy,Kelli Williamson,Francis O. Walker,Victoria Hunt,Un Jung Kang,Shirley Uy,Karen Bindauer,Jeannine Petit,David Simon,Lisa Scollins,Rachel Saunders Pullman,Karyn Boyer,Paul Gordon +98 more
TL;DR: Mutations in the parkin gene occur among individuals with PD with an older age at onset (≥60 years) who have a positive family history of the disease, and the clinical findings of parkin-positive individuals are remarkably similar to those without mutations.
Journal ArticleDOI
Significant Linkage of Parkinson Disease to Chromosome 2q36-37
Nathan Pankratz,William C. Nichols,Sean K. Uniacke,Cheryl Halter,Alice Rudolph,Cliff Shults,Cliff Shults,P. Michael Conneally,Tatiana Foroud,Lawrence I. Golbe,William C. Koller,Kelly E. Lyons,Karen Marder,Frederick J. Marshall,David Oakes,Aileen Shinaman,Eric Siemers,Joanne Wojcieszek,Joann Belden,Julie H. Carter,Richard Camicioli,Pamela Andrews,Magali Fernandez,Jean P. Hubble,Carson Reider,Ali H. Rajput,Alex Rajput,Theresa Shirley,Michel Panisset,Jean Hall,Tilak Mendis,David Grimes,Peggy Gray,Carmen Serrano Ramos,Sandra Roque,Stephen G. Reich,Becky Dunlop,Robert A. Hauser,Juan Sanchez-Ramos,Theresa A. Zesiewicz,Holly Delgado,Joseph H. Friedman,Hubert H. Fernandez,Margaret C. Lannon,Lauren Seeberger,Christopher F. O'Brien,Deborah Judd,Lawrence Elmer,Kathy Davis,Deborah Fontaine,Ronald F. Pfeiffer,Brenda Pfeiffer,Michael J. Aminoff,Mariann DiMinno,Daniel D. Truong,Mayank Pathak,Anhoa Tran,Robert L. Rodnitzky,Judith Dobson,Rajesh Pahwa,Stephanie Thomas,Danna Jennings,Kenneth Marek,Susan Mendick,Juliette Harris,William J. Weiner,Roger Kurlan,Debra Berry,Peter A. LeWitt,Maryan DeAngelis,Paul J. Tuite,Robyn Schacherer,W.R. Wayne Martin,Marguerite Wieler,Bala V. Manyam,Patricia Simpson,John M. Bertoni,Carolyn Peterson,Mark Forrest Gordon,Joanna Hamann,Joseph Jankovic,Christine Hunter,Stewart A. Factor,Sharon Evans,Anette Nieves,Julie So,Mark Stacy,Kelli Williamson,Francis O. Walker,Victoria Hunt,Un Jung Kang,Shirley Uy,Karen Blindauer,Jeannine Petit,David Simon,Lisa Scollins,Rachel Saunders Pullman,Karyn Boyar,Paul Gordon,Joan Werner +99 more
TL;DR: This work has expanded the sample to include 150 families meeting the strictest diagnostic definition of verified PD, and performs analyses using only those pedigrees with the strongest family history of PD, which strongly suggests that variation in a gene on chromosome 2q36-37 contributes to PD susceptibility.
Journal ArticleDOI
Genome-wide linkage analysis and evidence of gene-by-gene interactions in a sample of 362 multiplex Parkinson disease families
Nathan Pankratz,William C. Nichols,Sean K. Uniacke,Cheryl Halter,Jill R. Murrell,Alice Rudolph,Clifford W. Shults,Clifford W. Shults,P. Michael Conneally,Tatiana Foroud,Daniel D. Truong,Mayank Pathak,An Tran,Robert L. Rodnitzky,Judith Dobson,William C. Koller,William J. Weiner,Kelly E. Lyons,Roger Kurlan,Debra Berry,John M. Bertoni,Carolyn Peterson,W.R. Wayne Martin,Marguerite Wieler,Paul J. Tuite,Robyn Schacherer,Karen Marder,Juliette Harris,Joseph Jankovic,Christine Hunter,Anthony E. Lang,Galit Kleimer-Fisman,Anette Nieves,Julie So,Stewart A. Factor,Sharon Evans,Bala V. Manyam,Brian Wulbrecht,Francis O. Walker,Victoria Hunt,Mark Forrest Gordon,Joanna Hamman,Un Jang Kang,Joan Young,Karen Blindauer,Jeannine Petit,Jayaraman Rao,Maureen Cook,Mark Stacy,Kelli Williamson,Rachel Saunders Pullman,Karyn Boyar,Maureen A. Leehey,Theresa Derian,Paul Gordon,Joan Werner,Brad A. Racette,Laura Good,David Simon,Lisa Scollins,Donna Schwieterman,Richard B. Dewey,Melinda Meacham,James Sutton,Brad Hutchinson,Mandar Jog,Cheryl Horn,Kapil D. Sethi,J. Carpenter,Paul Atchison,Susan Rolli,Lewis Sudarsky,Claire Corwin,Miodrag Velickovic,Sabrina Phipps,Tanya Simuni,Annette Kaczmarek,Neal Hermanowicz,Shari Niswonger,Andrew Feigin,Barbara Shannon,Vincent Calabrese,Peggy Roberge,Hunter Homes,Lisa M. Shulman,Kelly Dustin,Todd Ajax,Janet Mannetter,G. David Podskalny,Lisa Giffin,Ryan J. Uitti,Margaret F. Turk +91 more
TL;DR: Findings demonstrate consistent evidence of linkage to chromosomes 2 and X and also support the hypothesis that gene-by-gene interactions are important in PD susceptibility.
Journal ArticleDOI
Long-term outcome of early versus delayed rasagiline treatment in early Parkinson's disease.
Robert A. Hauser,Mark F. Lew,Howard I. Hurtig,William G. Ondo,Joanne Wojcieszek,Cheryl Fitzer-Attas,Frederick J. Marshall,Irenita Gardiner,Nancy Pearson,Debra Berry,Kathleen M. Shannon,Jean A. Jaglin,William G. Ondo,Christine Hunter,Cathy R. Anderson,Peter A. LeWitt,Patricia Kaminski,Dawn Miller,Maryan DeAngelis,Janis M. Miyasaki,Julie So,Lisa Johnston,Caroline M. Tanner,Tracy Stewart,Lisa Tagg,Sheila Everett,Georgia Germain,Mickie Welsh,Micki McCollister,Linda L. Mann,Carlos Singer,William C. Koller,William J. Weiner,Dinorah Bateman,Tilak Mendis,Melodie Moterson,Cynthia Alcorn-Costa,Keely Haas,Peggy Gray,Davoud Mohtat,Neila Mendis,Laura Sutherland,Howard H. Hurtig,Mary Lloyd,Mary Mathews,Robert Hauser,Lisa Gauger,Patricia Dyches,Cheryl Newcomb,Jean P. Hubble,Karen Betcher,Carolyn C. Weeks,Sandra K. Kostyk,Ali H. Rajput,Marlene Gerow,Linda Klassen,Marianne Ewasnishin,Lawrence I. Golb,Vanessa Patterson,Deborah L. Caputo,Patricia Seuffert,Rajesh Pahwa,Tamara Gales,Lorette J. Jenkins,Amy Parsons,Scott Cradr,Jovianna N. Wellinghoff,Shantelle Coe,Cheryl Armstrong,Connie Kawai,Katherine B. Hawthorne,Kellie Gelles,Xiaoming Lu,Suzanne W. Schuman,Cheryl Cooper,Kenneth Marek,Barbara Fussell,Karen Caplan,Erica Barnabei,Karen Stavris,Kapil D. Sethi,J. Carpenter,James B. Osborne,Shoba Narayan,K. Ligon,Eric Molho,Sharon Evans,Jacqueline Nash,Diane Brown,Mark Stacy,Kelli Williamson,Peter Novak,Robert G. Feldman,Cathi A. Thomas,W.R. Wayne Martin,Pam King,Germanine McInnes,Shaunna Caouette,Jo Belden,Andew Feigin,Jean Ayan,Barbara Shannon,Charles H. Adler,Stephanie Newman,Teri Radam,Myrna Schear,Naomi Santoni,Sharon Wortzel,Nancy Saton,Paul J. Tuite,Susan Rolandelli,Jody Lowery,Brenda Ebbitt,Adrienne Baranauskas,Michael J. Aminoff,Mirann DiMinno,Jessie Roth,Tracey Borst,Julie Hevezi,Carolyn Deloa,Tracey Tam,Anita Lopez,John M. Bertoni,Larisa I. Skrypnik,Carolyn Peterson,Mark Forrest Gordon,Roberta Winnick,Sharyn Parness,Joanne Hamann,Vincent Calabrese,Peggy Roberge,Paul Atchison,Cathy W. Allen,Susan Rolli,Arif Dalvi,Un Jung Kang,Judy Richman,Shirley Uy +137 more
TL;DR: Compared to delayed start, early initiation of rasagiline provided long‐term clinical benefit, even in the face of treatment with other dopaminergic agents.