K
Katherine S. Elliott
Researcher at University of Oxford
Publications - 51
Citations - 14778
Katherine S. Elliott is an academic researcher from University of Oxford. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 26, co-authored 43 publications receiving 13239 citations. Previous affiliations of Katherine S. Elliott include Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
Timothy M. Frayling,Nicholas J. Timpson,Michael N. Weedon,Eleftheria Zeggini,Eleftheria Zeggini,Eleftheria Zeggini,Rachel M. Freathy,Cecilia M. Lindgren,John R. B. Perry,Katherine S. Elliott,Katherine S. Elliott,Hana Lango,Nigel W. Rayner,Nigel W. Rayner,Nigel W. Rayner,Beverley M. Shields,Lorna W. Harries,Jeffrey C. Barrett,Jeffrey C. Barrett,Sian Ellard,Christopher J. Groves,Christopher J. Groves,Bridget A. Knight,Ann-Marie Patch,Andy R Ness,Shah Ebrahim,Debbie A Lawlor,Susan M. Ring,Yoav Ben-Shlomo,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Ulla Sovio,Ulla Sovio,Amanda J. Bennett,Amanda J. Bennett,David Melzer,Luigi Ferrucci,Ruth J. F. Loos,Inês Barroso,Nicholas J. Wareham,Fredrik Karpe,Fredrik Karpe,Katharine R. Owen,Katharine R. Owen,Lon R. Cardon,Mark Walker,Graham A. Hitman,Graham A. Hitman,Colin N. A. Palmer,Colin N. A. Palmer,Alex S. F. Doney,Alex S. F. Doney,Andrew D. Morris,George Davey Smith,Andrew T. Hattersley,Mark I. McCarthy +55 more
TL;DR: A genome-wide search for type 2 diabetes–susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI).
Journal ArticleDOI
Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
Eleftheria Zeggini,Michael N. Weedon,Cecilia M. Lindgren,Timothy M. Frayling,Katherine S. Elliott,Hana Lango,Nicholas J. Timpson,John R. B. Perry,Nigel W. Rayner,Rachel M. Freathy,Jeffrey C. Barrett,Beverley M. Shields,Andrew P. Morris,Sian Ellard,Christopher J. Groves,Lorna W. Harries,Jonathan Marchini,Katharine R. Owen,Beatrice Knight,Lon R. Cardon,Mark Walker,Graham A. Hitman,Andrew D. Morris,Alex S. F. Doney,Mark I. McCarthy,Andrew T. Hattersley +25 more
TL;DR: These findings provide insight into the genetic architecture of type 2 diabetes, emphasizing the contribution of multiple variants of modest effect and underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 1 diabetes.
Journal ArticleDOI
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Eleftheria Zeggini,Laura J. Scott,Richa Saxena,Benjamin F. Voight,Jonathan Marchini,T Hu,de Bakker Piw.,de Bakker Piw.,de Bakker Piw.,Gonçalo R. Abecasis,Peter Almgren,Gregers S. Andersen,Kristin Ardlie,Kristina Bengtsson Boström,Richard N. Bergman,Lori L. Bonnycastle,Knut Borch-Johnsen,Knut Borch-Johnsen,Noël P. Burtt,H Chen,Peter S. Chines,Mark J. Daly,P Deodhar,Ding C-J.,Doney Asf.,William L. Duren,Katherine S. Elliott,Mike Erdos,Timothy M. Frayling,Rachel M. Freathy,Lauren Gianniny,Harald Grallert,Niels Grarup,Christopher J. Groves,Candace Guiducci,Torben Hansen,Christian Herder,Graham A. Hitman,Thomas Edward Hughes,Bo Isomaa,Anne U. Jackson,Torben Jørgensen,Augustine Kong,Kari Kubalanza,Finny G Kuruvilla,Finny G Kuruvilla,Johanna Kuusisto,Claudia Langenberg,Hana Lango,Torsten Lauritzen,Yun Li,Cecilia M. Lindgren,Cecilia M. Lindgren,Valeriya Lyssenko,Amanda F. Marvelle,Christine Meisinger,Kristian Midthjell,Karen L. Mohlke,Mario A. Morken,Andrew D. Morris,Narisu Narisu,Peter M. Nilsson,Katharine R. Owen,Palmer Cna.,Felicity Payne,Perry Jrb.,E Pettersen,Carl Platou,Inga Prokopenko,Inga Prokopenko,Lu Qi,Lu Qi,L Qin,Nigel W. Rayner,Nigel W. Rayner,Matthew G. Rees,J J Roix,A Sandbaek,Beverley M. Shields,Marketa Sjögren,Valgerdur Steinthorsdottir,Heather M. Stringham,Amy J. Swift,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Nicholas J. Timpson,Nicholas J. Timpson,Tiinamaija Tuomi,Jaakko Tuomilehto,Mark Walker,Richard M. Watanabe,Michael N. Weedon,Cristen J. Willer,Thomas Illig,Kristian Hveem,Frank B. Hu,Frank B. Hu,Markku Laakso,Kari Stefansson,Oluf Pedersen,Oluf Pedersen,Nicholas J. Wareham,Inês Barroso,Andrew T. Hattersley,Francis S. Collins,Leif Groop,Leif Groop,Mark I. McCarthy,Mark I. McCarthy,Michael Boehnke,David Altshuler +110 more
TL;DR: The results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D, and detect at least six previously unknown loci with robust evidence for association.
Journal ArticleDOI
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Benjamin F. Voight,Benjamin F. Voight,Laura J. Scott,Valgerdur Steinthorsdottir,Andrew P. Morris,Christian Dina,Christian Dina,Ryan P. Welch,Eleftheria Zeggini,Eleftheria Zeggini,Cornelia Huth,Yurii S. Aulchenko,Gudmar Thorleifsson,Laura J. McCulloch,Teresa Ferreira,Harald Grallert,Najaf Amin,Guanming Wu,Cristen J. Willer,Soumya Raychaudhuri,Soumya Raychaudhuri,Soumya Raychaudhuri,Steve McCarroll,Steve McCarroll,Claudia Langenberg,Oliver Hofmann,Josée Dupuis,Lu Qi,Lu Qi,Ayellet V. Segrè,Ayellet V. Segrè,Mandy van Hoek,Pau Navarro,Kristin Ardlie,Beverley Balkau,Rafn Benediktsson,Amanda J. Bennett,Roza Blagieva,Eric Boerwinkle,Lori L. Bonnycastle,Kristina Bengtsson Boström,Bert Bravenboer,Suzannah Bumpstead,N P Burtt,Guillaume Charpentier,Peter S. Chines,Marilyn C. Cornelis,David Couper,Gabe Crawford,Alex S. F. Doney,Katherine S. Elliott,Amanda F. Elliott,Amanda F. Elliott,Michael R. Erdos,Caroline S. Fox,Christopher S. Franklin,Martha Ganser,Christian Gieger,Niels Grarup,Todd Green,Todd Green,Simon J. Griffin,Christopher J. Groves,Candace Guiducci,Samy Hadjadj,Neelam Hassanali,Christian Herder,Bo Isomaa,Anne U. Jackson,Paul Johnson,Torben Jørgensen,Torben Jørgensen,Wen H. L. Kao,Norman Klopp,Augustine Kong,Peter Kraft,Johanna Kuusisto,Torsten Lauritzen,Man Li,Aloysius G Lieverse,Cecilia M. Lindgren,Valeriya Lyssenko,Michel Marre,Michel Marre,Thomas Meitinger,Kristian Midthjell,Mario A. Morken,Narisu Narisu,Peter M. Nilsson,Katharine R. Owen,Felicity Payne,John R. B. Perry,Ann-Kristin Petersen,Carl G. P. Platou,Christine Proença,Inga Prokopenko,Inga Prokopenko,Wolfgang Rathmann,N. William Rayner,N. William Rayner,Neil R. Robertson,Neil R. Robertson,Ghislain Rocheleau,Michael Roden,Mike Sampson,Richa Saxena,Richa Saxena,Beverley M. Shields,Peter Shrader,Gunnar Sigurdsson,Thomas Sparsø,Klaus Strassburger,Heather M. Stringham,Qi Sun,Amy J. Swift,Barbara Thorand,Jean Tichet,Tiinamaija Tuomi,Rob M. van Dam,Timon W. van Haeften,Thijs T. W. van Herpt,Jana V. van Vliet-Ostaptchouk,G. Bragi Walters,Michael N. Weedon,Cisca Wijmenga,Jacqueline C. M. Witteman,Richard N. Bergman,Stéphane Cauchi,Francis S. Collins,Anna L. Gloyn,Ulf Gyllensten,Torben Hansen,Winston Hide,Graham A. Hitman,Albert Hofman,David J. Hunter,Kristian Hveem,Markku Laakso,Karen L. Mohlke,Andrew D. Morris,Colin N. A. Palmer,Peter P. Pramstaller,Igor Rudan,Igor Rudan,Eric J.G. Sijbrands,Lincoln Stein,Jaakko Tuomilehto,Jaakko Tuomilehto,André G. Uitterlinden,Mark Walker,Nicholas J. Wareham,Richard M. Watanabe,Gonçalo R. Abecasis,Bernhard O. Boehm,Harry Campbell,Mark J. Daly,Mark J. Daly,Andrew T. Hattersley,Frank B. Hu,Frank B. Hu,James B. Meigs,James S. Pankow,Oluf Pedersen,H-Erich Wichmann,Inês Barroso,Jose C. Florez,Timothy M. Frayling,Leif Groop,Leif Groop,Robert Sladek,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,James F. Wilson,Thomas Illig,Philippe Froguel,Philippe Froguel,Cornelia M. van Duijn,Kari Stefansson,Kari Stefansson,David Altshuler,Michael Boehnke,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy +183 more
TL;DR: By combining genome-wide association data from 8,130 individuals with type 2 diabetes and 38,987 controls of European descent and following up previously unidentified meta-analysis signals, 12 new T2D association signals are identified with combined P < 5 × 10−8.
Journal ArticleDOI
Genome-wide association study identifies eight loci associated with blood pressure
Christopher Newton-Cheh,Christopher Newton-Cheh,Toby Johnson,Toby Johnson,Vesela Gateva,Martin D. Tobin,Murielle Bochud,Lachlan J. M. Coin,Samer S. Najjar,Jing Hua Zhao,Simon Heath,Susana Eyheramendy,Konstantinos A. Papadakis,Benjamin F. Voight,Benjamin F. Voight,Laura J. Scott,Feng Zhang,Martin Farrall,Toshiko Tanaka,Toshiko Tanaka,Chris Wallace,Chris Wallace,John C. Chambers,Kay-Tee Khaw,Peter M. Nilsson,Pim van der Harst,Silvia Polidoro,Diederick E. Grobbee,N. Charlotte Onland-Moret,N. Charlotte Onland-Moret,Michiel L. Bots,Louise V. Wain,Katherine S. Elliott,Alexander Teumer,Jian'an Luan,Gavin Lucas,Johanna Kuusisto,Paul Burton,David Hadley,Wendy L. McArdle,Morris J. Brown,Anna F. Dominiczak,Stephen Newhouse,Nilesh J. Samani,John Webster,Eleftheria Zeggini,Eleftheria Zeggini,Jacques S. Beckmann,Sven Bergmann,Sven Bergmann,Noha Lim,Kijoung Song,Peter Vollenweider,Gérard Waeber,Dawn M. Waterworth,Xin Yuan,Leif Groop,Marju Orho-Melander,Alessandra Allione,Alessandra Di Gregorio,Simonetta Guarrera,Salvatore Panico,Fulvio Ricceri,Valeria Romanazzi,Carlotta Sacerdote,Paolo Vineis,Inês Barroso,Manjinder S. Sandhu,Manjinder S. Sandhu,Robert Luben,Gabriel Crawford,Pekka Jousilahti,Markus Perola,Markus Perola,Michael Boehnke,Lori L. Bonnycastle,Francis S. Collins,Anne U. Jackson,Karen L. Mohlke,Heather M. Stringham,Timo T. Valle,Cristen J. Willer,Richard N. Bergman,Mario A. Morken,Angela Döring,Christian Gieger,Thomas Illig,Thomas Meitinger,Elin Org,Arne Pfeufer,H.-Erich Wichmann,Sekar Kathiresan,Sekar Kathiresan,Jaume Marrugat,Christopher J. O'Donnell,Christopher J. O'Donnell,Stephen M. Schwartz,David S. Siscovick,Isaac Subirana,Nelson B. Freimer,Anna-Liisa Hartikainen,Mark I. McCarthy,Paul F. O'Reilly,Leena Peltonen,Leena Peltonen,Anneli Pouta,Anneli Pouta,Paul E. de Jong,Harold Snieder,Wiek H. van Gilst,Robert Clarke,Anuj Goel,Anders Hamsten,David Altshuler,David Altshuler,Marjo Ritta Jarvelin,Marjo Ritta Jarvelin,Marjo Ritta Jarvelin,Paul Elliott,Edward G. Lakatta,Nita G. Forouhi,Nicholas J. Wareham,Ruth J. F. Loos,Panos Deloukas,Sheila Bingham,Diana Zelenika,David P. Strachan,Nicole Soranzo,Nicole Soranzo,Frances M K Williams,Guangju Zhai,Tim D. Spector,John F. Peden,Hugh Watkins,Luigi Ferrucci,Mark J. Caulfield,Patricia B. Munroe,Göran Berglund,Olle Melander,Guiseppe Matullo,Cuno S. P. M. Uiterwaal,Yvonne T. van der Schouw,Mattijs E. Numans,Florian Ernst,Georg Homuth,Uwe Völker,Roberto Eluosa,Markku Laakso,John M. C. Connell,Vincent Mooser,Veikko Salomaa,Jaakko Tuomilehto,Jaakko Tuomilehto,Maris Laan,Gerjan Navis,Udo Seedorf,Ann-Christine Syvänen,Giovanni Tognoni,Serena Sanna,Manuela Uda,Paul Scheet,David Schlessinger,Angelo Scuteri,Marcus Dörr,Stephan B. Felix,Thorsten Reffelmann,Roberto Lorbeer,Henry Völzke,Rainer Rettig,Pilar Galan,Serge Hercberg,Jaspal S. Kooner,Stefania Bandinelli,Pierre Meneton,Gonçalo R. Abecasis,John R. Thompson,Carolina A. Braga Marcano,Beverley Barke,Richard Dobson,Johannie Gungadoo,Kate L. Lee,Abiodun Onipinla,I. Wallace,Mingzhan Xue,David Clayton,H. T. Leung,Sarah Nutland,Neil Walker,John A. Todd,Helen Stevens,David B. Dunger,Barry Widmer,Kate Downes,Kate Downes,Lou R. Cardon,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Jeffrey C. Barrett,David M. Evans,Andrew P. Morris,Cecilia M. Lindgren,Nigel W. Rayner,N J Timpson,N J Timpson,Emily J. Lyons,Fredrik O. Vannberg,Adrian V. S. Hill,Yik Ying Teo,Kirk A. Rockett,Nicholas John Craddock,Antony P. Attwood,Antony P. Attwood,Claire Bryan,Suzannah Bumpstead,Amy Chaney,Jilur Ghori,Rhian G. William,Sarah E. Hunt,Michael Inouye,Emma Keniry,Emma King,Ralph McGinnis,Simon C. Potter,Rathi Ravindrarajan,Pamela Whittaker,David Withers,David Bentley,David Bentley,Christopher J. Groves,Audrey Duncanson,Willem H. Ouwehand,Willem H. Ouwehand,James P. Boorman,James P. Boorman,Barbera Cant,Jennifer Jolley,Alexandra S. Knight,Kerstin Koch,Niall C. Taylor,Nicholas A. Watkins,Nicholas A. Watkins,Thilo Winzer,Peter S. Braund,Richard J. Dixon,Massimo Mangino,Suzanne Stevens,Peter Donnely,Dan Davidson,Jonathan Marchini,I. C.A. Spencer,Niall Cardin,Teresa Ferreira,Joanne Pereira-Gale,Ingeleif B. Hallgrimsdottir,Bryan Howie,Zhan Su,Damjan Vukcevic,Doug Easton,Ursula Everson,Judith M. Hussey,Elizabeth Meech,Christopher Prowse,Graham R. Walters,Richard Jones,Susan M. Ring,Marcus Prembey,Marcus Prembey,Gerome Breen,David St Clair,Sian Ceasar,Katherine Gordon-Smith,Katherine Gordon-Smith,Lisa Jones,Lisa Jones,Elaine K. Green,Detelinea Grozeva,Marian L. Hamshere,Peter Holmans,Ian Jones,George Kirov,Valentina Moskovina,Ivan Nikolov,Michael Conlon O'Donovan,Michael John Owen,David A. Collier,Amanda Elkin,Anne Farmer,Richard Williamson,Peter McGruffin,Allan H. Young,I. Nicol Ferrier,Stephen G. Ball,Anthony J. Balmforth,Jennifer H. Barrett,D. Timothy Bishop,Mark M. Iles,Azhar Maqbool,Nadira Yuldasheva,Alistair S. Hall,Francesca Bredin,Mark Tremelling,Miles Parkes,Hazel E. Drummond,Charlie W. Lees,Elaine R. Nimmo,Jack Satsangi,Sheila A. Fisher,Cathryn M. Lewis,Clive M. Onnie,Nathalie J. Prescott,Christopher G. Mathew,Alastair Forbes,Jeremy D. Sanderson,Christopher Mathew,Jamie Barbour,M. Khalid Mohiuddin,Catherine E. Todhunter,John C. Mansfield,Tariq Ahmad,Fraser Cummings,Derek P. Jewell,Anne Barton,Ian N. Bruce,Hannah Donovan,Steve Eyre,Paul D. Gilbert,Samantha L. Hider,Anne Hinks,Sally John,Catherine Potter,Alan J. Silman,Deborah P M Symmons,Wendy Thomson,Jane Worthington,Timothy M. Frayling,Rachel M. Freathy,Hana Lango,John R. B. Perry,Michael N. Weedon,Andrew T. Hattersley,Beverley M. Shields,Graham A. Hitman,Mark Walker,Melanie J. Newport,Giorgio Sirugo,David J. Conway,Muminatou Jallow,Linda A. Bradbury,Jennifer L. Pointon,Matthew A. Brown,Matthew A. Brown,C Farrar,Paul Wordsworth,Jayne A. Franklyn,Joanne M. Heward,Matthew J. Simmonds,Stephen C.L. Cough,Sheila Seal,Michael R. Stratton,Nazneen Rahman,An Goris,Stephen Sawcer,Alastair Compston +362 more
TL;DR: In this paper, the association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10(-24)), CYP1A2(P = 1 × 10-23), FGF5 (P=1 × 10 -21), SH2B3(P= 3 × 10−18), MTHFR(MTHFR), c10orf107(P), ZNF652(ZNF652), PLCD3 (P,P = 5 × 10 −9),