K
Koichiro Ohmura
Researcher at Kyoto University
Publications - 184
Citations - 7612
Koichiro Ohmura is an academic researcher from Kyoto University. The author has contributed to research in topics: Rheumatoid arthritis & Medicine. The author has an hindex of 37, co-authored 157 publications receiving 6004 citations.
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Journal ArticleDOI
Genetics of rheumatoid arthritis contributes to biology and drug discovery
Yukinori Okada,Yukinori Okada,Di Wu,Di Wu,Di Wu,Gosia Trynka,Gosia Trynka,Towfique Raj,Towfique Raj,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Shinji Yoshida,Robert R. Graham,A. Manoharan,Ward Ortmann,Tushar Bhangale,Joshua C. Denny,Robert J. Carroll,Anne E. Eyler,Jeff Greenberg,Joel M. Kremer,Dimitrios A. Pappas,Lei Jiang,Jian Yin,Lingying Ye,Ding Feng Su,Jian Yang,Gang Xie,E.C. Keystone,Harm-Jan Westra,Tõnu Esko,Tõnu Esko,Tõnu Esko,Andres Metspalu,Xuezhong Zhou,Namrata Gupta,Daniel B. Mirel,Eli A. Stahl,Dorothee Diogo,Dorothee Diogo,Jing Cui,Jing Cui,Katherine P. Liao,Katherine P. Liao,Michael H. Guo,Michael H. Guo,Keiko Myouzen,Takahisa Kawaguchi,Marieke J H Coenen,Piet L. C. M. van Riel,Mart A F J van de Laar,Henk-Jan Guchelaar,Tom W J Huizinga,Philippe Dieudé,Xavier Mariette,S. Louis Bridges,Alexandra Zhernakova,Alexandra Zhernakova,René E. M. Toes,Paul P. Tak,Paul P. Tak,Paul P. Tak,Corinne Miceli-Richard,So Young Bang,Hye Soon Lee,Javier Martin,Miguel A. Gonzalez-Gay,Luis Rodriguez-Rodriguez,Solbritt Rantapää-Dahlqvist,Lisbeth Ärlestig,Hyon K. Choi,Hyon K. Choi,Yoichiro Kamatani,Pilar Galan,Mark Lathrop,Steve Eyre,Steve Eyre,John Bowes,John Bowes,Anne Barton,Niek de Vries,Larry W. Moreland,Lindsey A. Criswell,Elizabeth W. Karlson,Atsuo Taniguchi,Ryo Yamada,Michiaki Kubo,Jun Liu,Sang Cheol Bae,Jane Worthington,Jane Worthington,Leonid Padyukov,Lars Klareskog,Peter K. Gregersen,Soumya Raychaudhuri,Soumya Raychaudhuri,Barbara E. Stranger,Philip L. De Jager,Philip L. De Jager,Lude Franke,Peter M. Visscher,Matthew A. Brown,Hisashi Yamanaka,Tsuneyo Mimori,Atsushi Takahashi,Huji Xu,Timothy W. Behrens,Katherine A. Siminovitch,Shigeki Momohara,Fumihiko Matsuda,Kazuhiko Yamamoto,Robert M. Plenge,Robert M. Plenge +115 more
TL;DR: A genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries provides empirical evidence that the genetics of RA can provide important information for drug discovery, and sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis.
Journal ArticleDOI
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
Yukinori Okada,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Takahisa Kawaguchi,Eli A. Stahl,Eli A. Stahl,Fina A S Kurreeman,Fina A S Kurreeman,Fina A S Kurreeman,Nao Nishida,Hiroko Ohmiya,Keiko Myouzen,Meiko Takahashi,Tetsuji Sawada,Yuichi Nishioka,Masao Yukioka,Tsukasa Matsubara,Shigeyuki Wakitani,Ryota Teshima,Shigeto Tohma,Kiyoshi Takasugi,Kota Shimada,Akira Murasawa,Shigeru Honjo,Keitaro Matsuo,Hideo Tanaka,Kazuo Tajima,Taku Suzuki,Takuji Iwamoto,Yoshiya Kawamura,Hisashi Tanii,Yuji Okazaki,Tsukasa Sasaki,Peter K. Gregersen,Leonid Padyukov,Jane Worthington,Katherine A. Siminovitch,Mark Lathrop,Atsuo Taniguchi,Atsushi Takahashi,Katsushi Tokunaga,Michiaki Kubo,Yusuke Nakamura,Naoyuki Kamatani,Tsuneyo Mimori,Robert M. Plenge,Robert M. Plenge,Hisashi Yamanaka,Shigeki Momohara,Ryo Yamada,Fumihiko Matsuda,Kazuhiko Yamamoto +54 more
TL;DR: This study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10−8, including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2.
Journal ArticleDOI
Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome
Kazuhiko Arima,Akira Kinoshita,Hiroyuki Mishima,Nobuo Kanazawa,Takeumi Kaneko,Tsunehiro Mizushima,Kunihiro Ichinose,Hideki Nakamura,Akira Tsujino,Atsushi Kawakami,Masahiro Matsunaka,Shimpei Kasagi,Seiji Kawano,Shunichi Kumagai,Koichiro Ohmura,Tsuneyo Mimori,Makito Hirano,Satoshi Ueno,Keiko Tanaka,Masami Tanaka,Itaru Toyoshima,Hirotoshi Sugino,Akio Yamakawa,Keiji Tanaka,Norio Niikawa,Fukumi Furukawa,Shigeo Murata,Katsumi Eguchi,Hiroaki Ida,Koh-ichiro Yoshiura +29 more
TL;DR: The results show that a mutation within a proteasomesome subunit is the direct cause of a human disease and suggest that decreased proteasome activity can cause inflammation.
Journal ArticleDOI
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
Yuta Kochi,Yukinori Okada,Akari Suzuki,Katsunori Ikari,Chikashi Terao,Atsushi Takahashi,Keiko Yamazaki,Naoya Hosono,Keiko Myouzen,Tatsuhiko Tsunoda,Naoyuki Kamatani,Tatsuya Furuichi,Shiro Ikegawa,Koichiro Ohmura,Tsuneyo Mimori,Fumihiko Matsuda,Takuji Iwamoto,Shigeki Momohara,Hisashi Yamanaka,Ryo Yamada,Michiaki Kubo,Yusuke Nakamura,Kazuhiko Yamamoto +22 more
TL;DR: The results suggest that CCR6 is critically involved in IL-17–driven autoimmunity in human diseases, and is associated with susceptibility to Graves' and Crohn's diseases.
Journal ArticleDOI
The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody
Ran Nakashima,Yoshitaka Imura,Shio Kobayashi,Naoichiro Yukawa,Hajime Yoshifuji,Takaki Nojima,Daisuke Kawabata,Koichiro Ohmura,Takashi Usui,Takao Fujii,Katsuya Okawa,Tsuneyo Mimori +11 more
TL;DR: The anti-CADM-140 antibody was shown to recognize IFN induced with helicase C domain protein 1 (IFIH1), also known as the melanoma differentiation-associated gene 5 (MDA5), which is one of the RIG-I-like receptors and plays a role in innate immune responses.