M
Mark E. Cooper
Researcher at University of Queensland
Publications - 1514
Citations - 141899
Mark E. Cooper is an academic researcher from University of Queensland. The author has contributed to research in topics: Diabetes mellitus & Diabetic nephropathy. The author has an hindex of 158, co-authored 1463 publications receiving 124887 citations. Previous affiliations of Mark E. Cooper include University of Cambridge & University of Adelaide.
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Journal ArticleDOI
Pre-emptive intervention versus treatment as usual for infants showing early behavioural risk signs of autism spectrum disorder: a single-blind, randomised controlled trial.
Andrew J. O. Whitehouse,Andrew J. O. Whitehouse,Kandice J. Varcin,Gail A. Alvares,Josephine Barbaro,Josephine Barbaro,Catherine A Bent,Maryam Boutrus,Maryam Boutrus,Lacey Chetcuti,Lacey Chetcuti,Mark E. Cooper,Alena Clark,Emma Davidson,Stefanie Dimov,Cheryl Dissanayake,Cheryl Dissanayake,Jane Doyle,Megan Grant,Teresa Iacono,Murray T. Maybery,Sarah Pillar,Michelle Renton,Catherine Rowbottam,Nancy Sadka,Leonie Segal,Vicky Slonims,Carol Taylor,Scott Wakeling,Ming Wai Wan,John Wray,Jonathan Green,Jonathan Green,Kristelle Hudry +33 more
TL;DR: The efficacy of a pre-emptive intervention designed for infants showing early behavioural signs of autism spectrum disorder was tested and no significant differences were observed on secondary outcomes measuring caregiver non-directiveness, caregiver sensitive responding, and infant attentiveness.
Journal ArticleDOI
Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling
Daniel E. Croker,Peter N. Monk,Reena Halai,Geraldine Kaeslin,Zoe Schofield,Mike Cl Wu,Richard J. Clark,Mark At Blaskovich,Dimitrios Morikis,Christodoulos A. Floudas,Mark E. Cooper,Trent M. Woodruff +11 more
TL;DR: Two ligands were identified as functionally selective C5aR2 ligands, exhibiting selective recruitment of β‐arrestin 2 via C5 aR2, partial inhibition of C5A‐induced ERK1/2 activation and lipopolysaccharide‐stimulated interleukin‐6 release from human monocyte‐derived macrophages.
Journal Article
Ocular Delivery of Compacted DNA-Nanoparticles Does Not Elicit Toxicity in the Mouse Retina
TL;DR: Investigations show no signs of local inflammatory responses associated with subretinal injection of compacted DNA nanoparticles, indicating that the retina may be a suitable target for clinical nanoparticle-based interventions.
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PB1-F2 Peptide Derived from Avian Influenza A Virus H7N9 Induces Inflammation via Activation of the NLRP3 Inflammasome.
Anita A. Pinar,Jennifer K. Dowling,Natalie J. Bitto,Avril A. B. Robertson,Eicke Latz,Eicke Latz,Eicke Latz,Cameron R. Stewart,Grant R Drummond,Mark E. Cooper,Julie L. McAuley,Michelle D. Tate,Ashley Mansell,Ashley Mansell +13 more
TL;DR: It is suggested that PB1-F2 from H7N9 avian influenza A virus may be a major contributory factor to disease pathophysiology and excessive inflammation characteristic of clinical infections and that targeting the NLRP3 inflammasome may be an effective means to reduce the inflammatory burden associated with H7n9 infections.
Journal ArticleDOI
Pathophysiology of diabetic nephropathy
Mark E. Cooper,Mark E. Cooper,Richard E. Gilbert,Richard E. Gilbert,Murray Epstein,Murray Epstein +5 more
TL;DR: The importance of the various components, particularly with regard to the progression of DN, is currently being explored with the assistance of targeted drug intervention studies.