M
Mark E. Cooper
Researcher at University of Queensland
Publications - 1514
Citations - 141899
Mark E. Cooper is an academic researcher from University of Queensland. The author has contributed to research in topics: Diabetes mellitus & Diabetic nephropathy. The author has an hindex of 158, co-authored 1463 publications receiving 124887 citations. Previous affiliations of Mark E. Cooper include University of Cambridge & University of Adelaide.
Papers
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Journal ArticleDOI
Non-canonical Caspase-1 Signaling Drives RIP2-Dependent and TNF-α-Mediated Inflammation In Vivo
Sören Reinke,Mary Linge,Hans H. Diebner,Hella Luksch,Silke Glage,A Gocht,Avril A. B. Robertson,Mark E. Cooper,Sigrun R. Hofmann,Ronald Naumann,Mihail Sarov,Rayk Behrendt,Axel Roers,Frank Pessler,Joachim Roesler,Angela Rösen-Wolff,Stefan Winkler +16 more
TL;DR: Results reveal non-canonical caspase-1 signaling in vivo, and loss-of-function missense mutations in CASP1 secretes higher amounts of TNF-α.
Journal ArticleDOI
Cell division autoantigen 1 enhances signaling and the profibrotic effects of transforming growth factor-β in diabetic nephropathy
Yugang Tu,Tieqiao Wu,Aozhi Dai,Yen Pham,Phyllis Chew,Judy B. de Haan,Yu Wang,Ban-Hock Toh,Hong-Jian Zhu,Zemin Cao,Mark E. Cooper,Mark E. Cooper,Zhonglin Chai,Zhonglin Chai +13 more
TL;DR: In vitro and in vivo findings show that CDA1 has a critical role in TGF-β signaling in the kidney, and the Smad3 inhibitor, SIS3, markedly attenuated the activities of Cda1 in stimulating TGF -β signaling as well as gene expression of collagens I, III, and IV.
Book ChapterDOI
Modelling Plant Breeding Programs as Search Strategies on a Complex Response Surface
Dean Podlich,Mark E. Cooper +1 more
TL;DR: Simulation methodology was used to compare two selection strategies currently used in plant breeding and investigate their capacity to confront the diffculties associated with the influences of G×E interaction and epistasis.
Journal ArticleDOI
Diabetic retinopathy, classified using the lesion-aware deep learning system, predicts diabetic end-stage renal disease in chinese patients.
Lijun Zhao,Honghong Ren,Junlin Zhang,Yana Cao,Yiting Wang,Dan Meng,Yucheng Wu,Rui Zhang,Yutong Zou,Huan Xu,Lin Li,Jie Zhang,Mark E. Cooper,Nanwei Tong,Fang Liu +14 more
TL;DR: Although the severity of DR predicted diabetic ESRD in patients with T2DM and DN, the severities of DR and DN were not always consistent, especially in Patients with mild retinopathy or microalbuminuria.
Journal ArticleDOI
Renal function and risk for cardiovascular events in type 2 diabetic patients with hypertension: the RENAAL and LIFE studies.
Wouter B.A. Eijkelkamp,Zhongxin Zhang,Barry M. Brenner,Mark E. Cooper,Richard B. Devereux,B Dahlöf,Hans Ibsen,William F. Keane,Lars H Lindholm,Michael H. Olsen,Hans-Henrik Parving,Hans-Henrik Parving,Giuseppe Remuzzi,Shahnaz Shahinfar,Steven M. Snapinn,Kristian Wachtell,Dick de Zeeuw +16 more
TL;DR: A progressively higher risk for the composite cardiovascular endpoint was observed with incremental baseline serum creatinine in type 2 diabetic patients with hypertension, even within the normal range, and there appears to be no serum creat inine threshold level for an increased cardiovascular risk.