M
Mark E. Cooper
Researcher at University of Queensland
Publications - 1514
Citations - 141899
Mark E. Cooper is an academic researcher from University of Queensland. The author has contributed to research in topics: Diabetes mellitus & Diabetic nephropathy. The author has an hindex of 158, co-authored 1463 publications receiving 124887 citations. Previous affiliations of Mark E. Cooper include University of Cambridge & University of Adelaide.
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Journal ArticleDOI
Nox-4 deletion reduces oxidative stress and injury by PKC-α-associated mechanisms in diabetic nephropathy
Vicki Thallas-Bonke,Vicki Thallas-Bonke,Jay C. Jha,Jay C. Jha,Stephen P. Gray,David Barit,Hermann Haller,Harald H.H.W. Schmidt,Melinda T. Coughlan,Melinda T. Coughlan,Mark E. Cooper,Mark E. Cooper,Josephine M. Forbes,Josephine M. Forbes,Josephine M. Forbes,Karin Jandeleit-Dahm,Karin Jandeleit-Dahm +16 more
TL;DR: Examination of the effects of global deletion of a NADPH‐oxidase isoform, Nox4, was examined in mice with streptozotocin‐induced diabetes to suggest that deletion of Nx4 may alleviate renal injury via PKC‐dependent mechanisms, further strengthening the view that Nox 4 is a suitable target for renoprotection in diabetes.
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Genotype by environment interactions affecting grain sorghum. I. Characteristics that confound interpretation of hybrid yield
TL;DR: Past sorghum hybrid trials in north-eastern Australia have detected substantial genotype by environment (GxE) interactions for yield in sampling a variable target population of environments (TPE) that is affected by spatial and seasonal differences in crop water supply, which implies broad adaptation to different water regimes is required.
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Increased serum potassium affects renal outcomes : a post hoc analysis of the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial
Yan Miao,Daniela Dobre,H. J. Lambers Heerspink,Barry M. Brenner,Mark E. Cooper,H. H. Parving,Shahnaz Shahinfar,D. E. Grobbee,Dick de Zeeuw +8 more
TL;DR: Treatment with the ARB losartan is associated with a high risk of increased serum potassium levels, which is in turn associated with an increased risk of renal outcomes in patients with type 2 diabetes and nephropathy.
Journal ArticleDOI
Heparanase Is Involved in the Pathogenesis of Proteinuria as a Result of Glomerulonephritis
Vicki Levidiotis,Craig Freeman,Christos Tikellis,Christos Tikellis,Mark E. Cooper,Mark E. Cooper,David A. Power +6 more
TL;DR: Proteinuria was reduced in the absence of any altered glomerular C5b-9 activity, sheep IgG deposition, or rat anti-sheep antibody titers, and data suggest that heparanase contributes to the pathogenesis of proteinuria in PHN.
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Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes.
Melinda T. Coughlan,Melinda T. Coughlan,Tuong-Vi Nguyen,Sally A. Penfold,Gavin C Higgins,Gavin C Higgins,Vicki Thallas-Bonke,Sih Min Tan,Sih Min Tan,Nicole J Van Bergen,Karly C. Sourris,Karly C. Sourris,Brooke E. Harcourt,David R. Thorburn,Ian A. Trounce,Mark E. Cooper,Mark E. Cooper,Josephine M. Forbes,Josephine M. Forbes +18 more
TL;DR: Data show that changes in mitochondrial bioenergetics and dynamics may precede the development of the renal lesion in diabetes, and this supports the hypothesis that mitochondrial dysfunction is a primary cause of DKD.