Mark E. Cooper

TL;DR: The composite of 40% decline in eGFR, ESKD or renal death appears to provide reliable results similar to the traditional 57% decline as well as other surrogate kidney endpoints.

TL;DR: The broad substrate specificity of Set7 serves to control key transcriptional networks in embryonic stem cells and smooth muscle (SM) associated genes are subject to Set7-mediated regulation.

TL;DR: It is shown that in the absence of GMP synthase, C. neoformans becomes a guanine auxotroph, the production of key virulence factors is compromised, and the ability to infect nematodes and mice is abolished, highlighting the potential of GMp synthase to be exploited in the development of new therapeutic agents for the treatment of disseminated, life-threatening fungal infections.

TL;DR: Plasma AGE levels and NF-κB activity in PBMC were independent determinants of diastolic and pulse pressure in healthy normotensive individuals, suggesting a role for AGEs in the etiology of hypertension, possibly via the initiation of CLAIS and aortic stiffening.

TL;DR: The germplasm collection was found to be deficient in genotypes with high stolon density, high number of branches, highNumber of rooted nodes and large leaves, which could produce breeding populations to be used in recurrent selection for the development of white clover cultivars for dryland summer moisture stress environments in Australia.