Mark E. Cooper

TL;DR: It is shown that pretomanid also possesses potent activity against Giardia lamblia and Entamoeba histolytica, thus expanding the therapeutic potential of nitroimidazooxazines and suggesting that promising subclasses of bicyclic nitroIMidazoles containing different core architectures have potential for further development.

TL;DR: In this paper , the authors apply the framework of the "breeder's equation", which is used to predict the response to selection for a breeding program cycle, to successfully breed crops with improved levels of drought resistance, where the target population of environments (TPEs) is a spatially and temporally heterogeneous mixture of drought-affected and favorable (water-sufficient) environments.

TL;DR: Molecular modelling indicates rapid aggregation of this class of antibacterial agent prior to membrane association and insertion and confocal microscopy studies indicate that the primary site of interaction for this family of compounds is the bacterial membrane.

TL;DR: The molecular mechanisms of diabetic nephropathy are discussed and new therapies, including those targeting the accumulation of advanced glycation end products (AGEs) and reactive oxygen species (ROS) generation, are likely to feature in future treatment regimens.

TL;DR: The low temperature oxidation of β-amido selenides with MCPBA affords the corresponding β-AMIDI selenones in situ treatment of the selenone with KOtBu gives Nacylaziridines in good yield as mentioned in this paper.