O
Olivier Elemento
Researcher at Cornell University
Publications - 596
Citations - 38936
Olivier Elemento is an academic researcher from Cornell University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 82, co-authored 471 publications receiving 27739 citations. Previous affiliations of Olivier Elemento include Princeton University & Max Planck Society.
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Journal ArticleDOI
Genomic instability is enriched in localized prostate cancers from men of African ancestry.
Jones T. Nauseef,Yajas Shah,Alon Shaiber,Joel Rosiene,David Wilkes,Michael Sigouros,Jyothi Manohar,Panagiotis J. Vlachostergios,Brian D. Robinson,Olivier Elemento,David M. Nanus,Juan Miguel Mosquera,Marcin Imielinski +12 more
TL;DR: Analysis of the largest AA cohort to date of WGS HNPC has revealed an ancestry-specific somatic mutational processes resulting in elevated rate of MMR-linked SNVs, replication-slippage associated small deletions, and MSI, relative to EA.
Journal ArticleDOI
Abstract 1031: PRMT5 inhibition alters mitochondrial dynamics in mantle cell lymphoma, creating vulnerability to BH3 mimetic compounds
Claire Hinterschied,Fiona Brown,Janani Ravikrishnan,J. Helmig-Mason,Kris Vaddi,Peggy Scherle,Jennifer A. Woyach,Selina Chen-Kiang,Olivier Elemento,J. Paik,Robert A. Baiocchi +10 more
TL;DR: Results provide rationale for combining BH3 mimetics and PRMT5 inhibition in clinical trials as a novel treatment strategy for MCL, and identify the intrinsic apoptotic pathway as an attractive target in MCL.
Posted ContentDOI
Liquid-biopsy transcriptomic profiling uncovers molecular mediators of resistance to androgen receptor signaling inhibition in lethal prostate cancer
Jiaren Zhang,Zimmermann B,Giuseppe Galletti,Susan Halabi,Ada Gjyrezi,Qian Yang,Santosh Gupta,Akanksha Verma,Andrea Sboner,Monika Anand,Daniel J. George,Simon G. Gregory,S. Hong,S. Hong,Pascual,Mavragani Cp,Emmanuel S. Antonarakis,David M. Nanus,Scott T. Tagawa,Olivier Elemento,Andrew J. Armstrong,Paraskevi Giannakakou +21 more
TL;DR: In this paper, the authors performed transcriptome analysis of circulating tumor cells (CTCs) and peripheral blood mononuclear cells (PBMC) in the context of a prospective clinical trial of men with metastatic castration-resistant prostate cancer (mCRPC) treated with abiraterone (Abi) or enzalutamide (Enza).
Proceedings ArticleDOI
1117 A patient-derived tumor organoid platform to investigate radiation-induced neoantigen exposure
Samantha J. Van Nest,Jared A. Capuano,Tuo Zhang,Bhavneet Bhinder,Xiang Zhao,Adriana Irizarry,Laura Martin,Silvia C. Formenti,Olivier Elemento,Nils Rudqvist,Sandra Demaria +10 more
TL;DR: Lhuillier et al. as discussed by the authors showed that radiation therapy (RT) upregulates the expression of genes containing MANA in a preclinical model, resulting in enhanced presentation of the derived MANA.
Journal ArticleDOI
034 Tissue specificity of dendritic cells supersedes subset identity
TL;DR: In this article , the authors found that tissue myeloid maturation and migration programing supersedes subset diversification, and is enforced at the level of the chromatin, and confirmed a site-specific regulation of IFNgR1 signaling in Dendritic cells.