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Olivier Elemento
Researcher at Cornell University
Publications - 596
Citations - 38936
Olivier Elemento is an academic researcher from Cornell University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 82, co-authored 471 publications receiving 27739 citations. Previous affiliations of Olivier Elemento include Princeton University & Max Planck Society.
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Journal ArticleDOI
Nuclear envelope expansion is crucial for proper chromosomal segregation during a closed mitosis
Ai Takemoto,Shigehiro A. Kawashima,Juanjuan Li,Linda Jeffery,Kenzo Yamatsugu,Olivier Elemento,Paul Nurse +6 more
TL;DR: Identification of a new fatty acid synthase inhibitor for nuclear division by a chemical genetic screen revealed a link between nuclear envelope expansion and faithful chromosome segregation in a closed mitosis.
Journal ArticleDOI
Integrative multiplatform molecular profiling of benign prostatic hyperplasia identifies distinct subtypes.
Deli Liu,Jonathan Shoag,Daniel Poliak,Ramy Goueli,Vaishali Ravikumar,David Redmond,Aram Vosoughi,Jacqueline Fontugne,Jacqueline Fontugne,Heng Pan,Daniel J. Lee,Domonique Thomas,Keyan Salari,Zongwei Wang,Alessandro Romanel,Alexis E. Te,Richard K. Lee,Bilal Chughtai,Aria F. Olumi,Juan Miguel Mosquera,Juan Miguel Mosquera,Francesca Demichelis,Olivier Elemento,Olivier Elemento,Mark A. Rubin,Mark A. Rubin,Andrea Sboner,Christopher E. Barbieri,Christopher E. Barbieri +28 more
TL;DR: It is concluded that Benign prostatic hyperplasia consists of distinct molecular subgroups, with potential for subtype-specific precision therapy, and men exposed to mTOR inhibitors show a significant decrease in prostate size.
Journal ArticleDOI
The GA4GH Phenopacket schema defines a computable representation of clinical data
Julius O.B. Jacobsen,Michael Baudis,Gareth Baynam,Jacques S. Beckmann,Sergi Beltran,Orion J. Buske,Tiffany J. Callahan,Christopher G. Chute,Mélanie Courtot,Daniel Danis,Olivier Elemento,Andrea Essenwanger,Robert R. Freimuth,Michael A. Gargano,Tudor Groza,Ada Hamosh,Nomi L. Harris,Rajaram Kaliyaperumal,Kevin C K Lloyd,Alyazia Khalifa,Peter Krawitz,Sebastian Köhler,Bryan Laraway,Heikki Lehväslaiho,Leslie Matalonga,Julie A. McMurry,Alejandro Metke-Jimenez,Christopher J. Mungall,Monica Munoz-Torres,Soichi Ogishima,Anastasios Papakonstantinou,D. Piscia,Nikolas Pontikos,Núria Queralt-Rosinach,Marco Roos,Julian Sass,Paul N. Schofield,Dominik Seelow,Anastasios Siapos,Damian Smedley,Lindsay Smith,Robin Steinhaus,Jagadish Chandrabose Sundaramurthi,Emilia M. Swietlik,Sylvia Thun,Nicole Vasilevsky,Alex H. Wagner,Jeremy L. Warner,Claus Weiland,Melissa A. Haendel,Peter N. Robinson +50 more
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Epigenetic reprogramming sensitizes immunologically silent EBV+ lymphomas to virus-directed immunotherapy.
Tanner Dalton,Ekaterina Doubrovina,Dmitry Pankov,Raymond Reynolds,Hanna Scholze,Annamalai Selvakumar,Teresa Vizconde,Bhumesh Savalia,Vadim G. Dyomin,Christoph Weigel,Christopher C. Oakes,Alicia Alonso,Olivier Elemento,Heng Pan,Jude M. Phillip,Richard J. O'Reilly,Benjamin E. Gewurz,Benjamin E. Gewurz,Ethel Cesarman,Lisa Giulino-Roth +19 more
TL;DR: Decitabine is identified as a potent inducer of immunogenic EBV antigens including LMP1, EBNA2 and EBNA3C and highlighted in a novel therapeutic approach to sensitize EBV+ lymphomas to immunotherapy.
Journal ArticleDOI
A Computational Drug Repositioning Approach for Targeting Oncogenic Transcription Factors
Kaitlyn Gayvert,Etienne Dardenne,Cynthia Cheung,Mary Regina Boland,Tal Lorberbaum,Jackline Wanjala,Yu Chen,Mark A. Rubin,Nicholas P. Tatonetti,David S. Rickman,Olivier Elemento +10 more
TL;DR: Application of CRAFTT to ERG, a pro-invasive, frequently overexpressed oncogenic TF, predicted that dexamethasone would inhibit ERG activity, and analysis of electronic medical record data indicates a protective role for dexamETHasone against prostate cancer.