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Olivier Elemento
Researcher at Cornell University
Publications - 596
Citations - 38936
Olivier Elemento is an academic researcher from Cornell University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 82, co-authored 471 publications receiving 27739 citations. Previous affiliations of Olivier Elemento include Princeton University & Max Planck Society.
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Journal ArticleDOI
Clinical interpretation of whole-genome and whole-transcriptome sequencing for precision oncology
Olivier Elemento,Haoqing Jiang +1 more
TL;DR: In this paper , the authors describe the challenges of interpreting WGTS interpretation and the opportunities with comprehensive genomic testing and the challenges associated with these comprehensive tests are accompanied by many challenges ranging from the extent and diversity of sequence alterations detected by these methods to the complexity and limited existing standardization in interpreting them.
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Precision medicine program for whole-exome sequencing (WES) provides new insight on platinum sensitivity in advanced prostate cancer (PCa).
Himisha Beltran,Andrea Sboner,Juan Miguel Mosquera,David S. Rickman,Kenneth Eng,Davide Prandi,Myriam Kossai,Bishoy Faltas,Chantal Pauli,Jacqueline Fontugne,Colin Collins,Martin E. Gleave,Yuzhuo Wang,Brian D. Robinson,Alessandro Romanel,David M. Nanus,Scott T. Tagawa,Francesca Demichelis,Olivier Elemento,Mark A. Rubin +19 more
TL;DR: WES has provided insight into the genomic landscape of PCa and the next step for precision medicine requires prospective patient follow-up and clinical and functional validation of patients with PCa.
Journal ArticleDOI
Multicenter Phase II Study of Cabazitaxel in Advanced Gastroesophageal Cancer: Association of HER2 Expression and M2-Like Tumor-Associated Macrophages with Patient Outcome
Manish A. Shah,Peter C. Enzinger,Andrew H. Ko,Allyson J. Ocean,Philip A. Philip,Prashant V. Thakkar,Kyle Cleveland,Yao Lu,Jeremy S. Kortmansky,Paul J. Christos,Chao Zhang,Navjot Kaur,Dina Elmonshed,Giuseppe Galletti,Sandipto Sarkar,Bhavneet Bhinder,Meredith E. Pittman,Olga Plotnikova,Nikita Kotlov,Felix Frenkel,Aleksander Bagaev,Olivier Elemento,Doron Betel,Paraskevi Giannakakou,Heinz-Josef Lenz +24 more
TL;DR: Cabazitaxel has modest activity in advanced gastric cancer, including in patients previously treated with taxanes, and Her2 amplification/overexpression and M2 high macrophage signature are potential biomarkers for taxane efficacy that warrant further evaluation.
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Generating a neoantigen map of advanced urothelial carcinoma by whole exome sequencing.
Bishoy Faltas,Bhavneet Bhinder,Himisha Beltran,Scott T. Tagawa,Ana M. Molina,David M. Nanus,Olivier Elemento,Mark A. Rubin +7 more
TL;DR: A significant correlation between global somatic mutation rates, and neo-epitope burden was observed, and a similar correlation was observed between single nucleotide variants (SNV) and Neoantigen burdens.
Posted ContentDOI
Extracellular Microenvironment in Patient-derived Hydrogel Organoids of Prostate Cancer Regulates Therapeutic Response
Matthew J. Mosquera,Rohan Bareja,Rohan Bareja,Jacob Bernheim,Muhammad Asad,Cynthia Cheung,Michael Sigouros,Varun V. Prabhu,Joshua E. Allen,M. Laura Martin,Loredana Puca,Mark A. Rubin,Mark A. Rubin,Himisha Beltran,Himisha Beltran,Juan Miguel Mosquera,Juan Miguel Mosquera,Olivier Elemento,Olivier Elemento,Ankur Singh +19 more
TL;DR: The synthetic platform can provide a more realistic prostate-specific microenvironment and subsequently enable the development of effective targeted therapeutics for prostate cancers, and develop synthetic hydrogels that recapitulate the tumor ECM.