O
Olivier Elemento
Researcher at Cornell University
Publications - 596
Citations - 38936
Olivier Elemento is an academic researcher from Cornell University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 82, co-authored 471 publications receiving 27739 citations. Previous affiliations of Olivier Elemento include Princeton University & Max Planck Society.
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Drug knowledge bases and their applications in biomedical informatics research.
TL;DR: A review of existing popular drug knowledge bases and their applications in drug-related studies is provided to help researchers recognize the state of the art and design better knowledge bases in the future.
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Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia.
Takenobu Nii,Varun V. Prabhu,Vivian Ruvolo,Neel Madhukar,Ran Zhao,Hong Mu,Lauren Heese,Yuki Nishida,Kensuke Kojima,Kensuke Kojima,Mathew J. Garnett,Ultan McDermott,Cyril H. Benes,Neil Charter,Sean Deacon,Olivier Elemento,Joshua E. Allen,Wolfgang Oster,Martin Stogniew,Jo Ishizawa,Michael Andreeff +20 more
TL;DR: Results suggest ONC212 as a novel therapeutic agent for AML as well as potential eradication of AML initiating cells in an NSG PDX model and was highly synergistic in combination with ABT-199.
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Prediction of Genetic Interactions Using Machine Learning and Network Properties.
TL;DR: The state-of-the-art approaches, strategies, and rigorous evaluation methods for learning and predicting GIs, both under general (healthy/standard laboratory) conditions and under specific contexts, such as diseases are reviewed.
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Integrative Molecular Analysis of Patients With Advanced and Metastatic Cancer
Verena Sailer,Kenneth Eng,Tuo Zhang,Rohan Bareja,David J. Pisapia,Alexandros Sigaras,Bhavneet Bhinder,Alessandro Romanel,David Wilkes,Evan Sticca,Joanna Cyrta,Rema Rao,Sheena Sahota,Chantal Pauli,Shaham Beg,Samaneh Motanagh,Myriam Kossai,Jacqueline Fontunge,Loredana Puca,Hanna Rennert,Jenny Xiang,Noah Greco,Rob Kim,Theresa Y. MacDonald,Terra J. McNary,Mirjam Blattner-Johnson,Marc H. Schiffman,Bishoy Faltas,Jeffrey P. Greenfield,David S. Rickman,Eleni Andreopoulou,Kevin Holcomb,Linda T. Vahdat,Douglas S. Scherr,Koen van Besien,Christopher E. Barbieri,Brian D. Robinson,Howard A. Fine,Allyson J. Ocean,Ana M. Molina,Manish A. Shah,David M. Nanus,Qiulu Pan,Francesca Demichelis,Scott T. Tagawa,Wei Song,Juan Miguel Mosquera,Andrea Sboner,Mark A. Rubin,Olivier Elemento,Himisha Beltran +50 more
TL;DR: A precision medicine program for patients with advanced cancer using integrative whole-exome sequencing and transcriptome analysis may uncover informative alterations for an advanced pan-cancer patient population.
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The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3
Giovanni Gambi,Elisabetta Di Simone,Veronica Basso,Luisa Ricci,Rui Wang,Akanksha Verma,Olivier Elemento,Maurilio Ponzoni,Giorgio Inghirami,Giorgio Inghirami,Giorgio Inghirami,Laura Icardi,Anna Mondino +12 more
TL;DR: This study delineates the transcriptional regulatory complex Sin3A as a mediator of STAT3 transcriptional repressor activity and identifies the STAT3/Sin3A axis as a druggable target to antagonize STAT3-addicted tumors.