O
Olivier Elemento
Researcher at Cornell University
Publications - 596
Citations - 38936
Olivier Elemento is an academic researcher from Cornell University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 82, co-authored 471 publications receiving 27739 citations. Previous affiliations of Olivier Elemento include Princeton University & Max Planck Society.
Papers
More filters
Journal ArticleDOI
HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway.
Yi Liu,Dong Soon Choi,Jianting Sheng,Joe Ensor,Diana Hwang Liang,Cristian Rodriguez-Aguayo,Amanda Polley,Steve Benz,Olivier Elemento,Akanksha Verma,Yang Cong,Helen Wong,Wei Qian,Zheng Li,Sergio Granados-Principal,Gabriel Lopez-Berestein,Melissa D. Landis,Roberto R. Rosato,Bhuvanesh Dave,Stephen T. C. Wong,Dario Marchetti,Anil K. Sood,Jenny C. Chang +22 more
TL;DR: It is revealed that BCSCs in TNBC depend on the transcription regulator HN1L for the sustained activation of the LEPR-STAT3 pathway, which makes it a potentially important target for both prognosis and BCSC therapy.
Journal ArticleDOI
Immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival
Geoffrey J. Markowitz,Lauren S. Havel,Michael J. Crowley,Yi Ban,Sharrell Lee,Jennifer S. Thalappillil,Navneet Narula,Bhavneet Bhinder,Olivier Elemento,Stephen T. C. Wong,Dingcheng Gao,Nasser K. Altorki,Vivek Mittal +12 more
TL;DR: Insight is provided into temporal evolution of the phenotypic effects of PD-1/PD-L1 activation and inhibition and targeting of this axis early in lung cancer progression is motivated.
Journal ArticleDOI
Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance
Reema P. Vazirani,Akanksha Verma,L Amanda Sadacca,Melanie S Buckman,Belén Picatoste,Muheeb Beg,Christopher Torsitano,Joanne Bruno,Rajesh T. Patel,Kotryna Simonyte,João Paulo G Camporez,Gabriela Virginia Moreira,Domenick J. Falcone,Domenico Accili,Olivier Elemento,Gerald I. Shulman,Barbara B. Kahn,Timothy E. McGraw +17 more
TL;DR: It is demonstrated that both insulin-stimulated glucose uptake and GLUT4 translocation to the plasma membrane are reduced by about half in adipocytes from adipose-specific Rab10 knockout (KO) mice, underscoring the physiological significance of the precise control of insulin-regulated trafficking in adipocyte trafficking.
Journal ArticleDOI
Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression
Viviana Anelli,Jacques A. Villefranc,Sagar Chhangawala,Raul Martinez-McFaline,Eleonora Riva,Anvy Nguyen,Akanksha Verma,Rohan Bareja,Zhengming Chen,Theresa Scognamiglio,Olivier Elemento,Yariv Houvras +11 more
TL;DR: A novel model of thyroid carcinoma in zebrafish that reveals temporal changes due to BRAFV600E is described and it is suggested that expression of TWIST2 plays a role in an early step of BRAFv600E-mediated transformation.
Journal ArticleDOI
Predictive features of ligand-specific signaling through the estrogen receptor.
Jerome C. Nwachukwu,Sathish Srinivasan,Yangfan Zheng,Song Wang,Jian Min,Chune Dong,Zongquan Liao,Jason Nowak,Nicholas J. Wright,René Houtman,Kathryn E. Carlson,Jatinder S. Josan,Olivier Elemento,John A. Katzenellenbogen,Hai-Bing Zhou,Kendall W. Nettles +15 more
TL;DR: In this paper, the authors synthesized 241 estrogen receptor-α (ERα)-targeted breast cancer therapies such as tamoxifen and compared ligand response using quantitative bioassays for canonical ERα activities and X-ray crystallography.