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Olivier Elemento
Researcher at Cornell University
Publications - 596
Citations - 38936
Olivier Elemento is an academic researcher from Cornell University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 82, co-authored 471 publications receiving 27739 citations. Previous affiliations of Olivier Elemento include Princeton University & Max Planck Society.
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Journal ArticleDOI
LGG-47. Single-cell RNA Sequencing Reveals Immunosuppressive Myeloid Cell Diversity During Malignant Progression in Glioma
Sakthi Rajendran,Clayton R. Peterson,Alessandro Canella,Yang Hu,Amy C. Gross,Maren Cam,Akdes Serin-Harmanci,Rosario Distefano,Giovanni Nigita,Wesley Wang,Mark E. Hester,Katherine E. Miller,Olivier Elemento,Ryan D. Roberts,Eric C. Holland,Ganesh Rao,Elaine R. Mardis,Prajwal Rajappa +17 more
TL;DR: Targeting these factors during the LGG therapeutic window may inhibit myeloid cells and intra-tumoral macrophages and attenuate their immunosuppressive properties and impair malignant progression.
Journal ArticleDOI
Abstract PR008: An epigenetic memory of inflammation controls context-dependent lineage plasticity and KRAS-driven tumorigenesis in the pancreas
David J Falvo,Adrien Grimont,Paul Zumbo,Julie L. Yang,Alexa Osterhoudt,Grace Pan,André F. Rendeiro,John E. Wilkinson,Friederike Dundar,Olivier Elemento,Rhonda K. Yantiss,Doron Betel,Richard Koche,Rohit Chandwani +13 more
TL;DR: In this article , the authors employ lineage-traced mouse models to delineate the chromatin dynamics that accompany the cycle of metaplasia and regeneration following pancreatitis, and unveil the presence of an epigenetic memory of inflammation in the pancreatic acinar cell compartment.
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Abstract B55: Patient-Derived Organoids model time-dependent sensitivities to PARP inhibitors in patients with metastatic colorectal cancer
Mariangela Mastropaolo,Helen P. Kuo,John N. Nguyen,F. M. Rowdo,Jared A. Capuano,Jenna E. Moyer,Julianne M Hall,Olivier Elemento +7 more
TL;DR: Mastropaolo et al. as discussed by the authors used PDTOs to study the pharmacogenomics between PARPis and HR deficient cancer and found that organoids were more sensitive to talazoparib than to olaparib.
Journal ArticleDOI
Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma.
Evan Noch,Isaiah Yim,Yuqing Qiu,Hiranmayi Ravichandran,Junbum Kim,André F. Rendeiro,Melissa Davis,Olivier Elemento,David J. Pisapia,Kevin Zhai,H. Carl Lekaye,Jason A. Koutcher,Patrick Y. Wen,Keith L. Ligon,Lewis C. Cantley +14 more
TL;DR: The effect of anti-hyperglycemic regimens metformin and the ketogenic diet were evaluated in combination with PI3K inhibition in a mouse model of glioblastoma and evaluated the association of glycemic control as discussed by the authors .
Posted ContentDOI
Simple Linear Cancer Risk Prediction Models with Novel Features Outperform Complex Approaches
TL;DR: In this paper, the authors developed linear and machine learning models for the prediction of 12 different cancers diagnoses within a 10-year time span using data from the UK Biobank, a large prospective health study.