Olivier Elemento

TL;DR: The data suggest that RNA-Seq does not detect a significant proportion of clinically relevant mutations and should be used with caution in clinical practice for detecting DNA mutations.

TL;DR: Pseudo-temporal reconstruction of the hierarchy of disease progression revealed dynamic time changes in the global population recapitulating individual patients and the development of an eight-marker classifier of disease severity.

TL;DR: It is demonstrated that oncogenic transcription factor overexpression is associated with global, reproducible and functionally coherent changes in chromatin organization, and a yet unappreciated role for transcription factors in promoting genomic alterations through their effect on chromatin architecture is suggested.

TL;DR: This paper showed that tumor secreted lactate downregulated p62 transcriptionally through a mechanism involving reduction of the NAD+/NADH ratio, which impairs poly(ADP-ribose)-polymerase 1 (PARP-1) activity.

TL;DR: In this paper, the putative extracellular matrix (ECM) cues that regulate the phenotypic, transcriptomic, and epigenetic underpinnings of prostate cancer were defined.