O
Olivier Elemento
Researcher at Cornell University
Publications - 596
Citations - 38936
Olivier Elemento is an academic researcher from Cornell University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 82, co-authored 471 publications receiving 27739 citations. Previous affiliations of Olivier Elemento include Princeton University & Max Planck Society.
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Journal ArticleDOI
TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells.
Nipun Verma,Nipun Verma,Heng Pan,Louis C. Dore,Abhijit Shukla,Qing V. Li,Qing V. Li,Bobbie Pelham-Webb,Virginia Teijeiro,Virginia Teijeiro,Federico Gonzalez,Andrei V. Krivtsov,Chan Jung Chang,Eirini P. Papapetrou,Chuan He,Olivier Elemento,Danwei Huangfu +16 more
TL;DR: It is concluded that TET proteins safeguard bivalent promoters from de novo methylation to ensure robust lineage-specific transcription upon differentiation.
Journal ArticleDOI
Oncogene-mediated alterations in chromatin conformation.
David S. Rickman,David Soong,Benjamin J. Moss,Juan Miguel Mosquera,Jan Dlabal,Stéphane Terry,Theresa Y. MacDonald,Joseph Tripodi,Karen L. Bunting,Vesna Najfeld,Francesca Demichelis,Ari Melnick,Olivier Elemento,Mark A. Rubin +13 more
TL;DR: It is demonstrated that oncogenic transcription factor overexpression is associated with global, reproducible, and functionally coherent changes in chromatin organization, as genomic alterations in other cancer types frequently give rise to aberrant transcription factor expression.
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Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells
Alejandra Mendoza,Victoria Fang,Cynthia Chen,Madhavika N. Serasinghe,Akanksha Verma,James E. Muller,V. Sai Chaluvadi,Michael L. Dustin,Michael L. Dustin,Timothy Hla,Olivier Elemento,Jerry E. Chipuk,Susan R. Schwab +12 more
TL;DR: S1P signalling maintains the mitochondrial content of naive T cells, providing cells with the energy to continue their constant migration, and these findings suggest that it may be possible simultaneously to target autoreactive or malignant cell survival.
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NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche.
Chiung-Ying Chang,H. Amalia Pasolli,Eugenia G. Giannopoulou,Géraldine Guasch,Richard M. Gronostajski,Olivier Elemento,Elaine Fuchs +6 more
TL;DR: These findings reveal how melanocyte and hair follicle stem cell behaviours maintain reliance upon cooperative factors within the niche, and how this can be uncoupled in injury, stress and disease states.
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Fast and systematic genome-wide discovery of conserved regulatory elements using a non-alignment based approach.
Olivier Elemento,Saeed Tavazoie +1 more
TL;DR: A powerful new approach for discovering globally conserved regulatory elements between two genomes is described, which is fast, simple and comprehensive, without requiring alignments.