Olivier Elemento

TL;DR: A comprehensively surveyed DNA-binding specificities of all 27 members of the ApiAP2 protein family from Plasmodium falciparum revealing unique binding preferences for the majority of these DNA binding proteins and infer the trans-factors associated with previously reported plasmodial cis-elements.

TL;DR: This survey provides a systematic review on the emerging field of graph convolutional networks and their applications in drug discovery and molecular informatics and describes the existing applications through four perspectives: molecular property and activity prediction, interaction prediction, synthesis prediction and de novo drug design.

TL;DR: It is found that breakdown of stem cell lineage confinement-granting privileges associated with both fates-is not only hallmark but also functional in cancer development and shows that lineage plasticity is critical in wound repair, where it operates transiently to redirect fates.

TL;DR: The generation and characterization of tumor organoids derived from needle biopsies of metastatic lesions from four patients are reported, and genomic, transcriptomic, and epigenomic concordance between organoids and their corresponding patient tumors are demonstrated.

TL;DR: This work performed whole-exome sequencing and clonality analysis of 72 urothelial carcinoma samples, including 16 matched sets of primary and advanced tumors prospectively collected before and after chemotherapy, to provide insights into how selective pressure from chemotherapy directs the evolution of uroclinical carcinoma and shapes its clonal architecture.