Olivier Elemento

TL;DR: In this paper, the authors carried out transcriptome profiling to define the molecular changes that occur in the breast related to excess body fat and white adipose tissue (WAT) inflammation.

TL;DR: In this article, the authors explored potential mechanisms and clinical relevance of cohesin deficiency in germinal center (GC) derived lymphoma in mice and found that cohesins deficiency largely induces lymphomas through disruption of enhancer-promoter interactions of terminal differentiation and tumor suppressor genes.

TL;DR: The aim of this study was to determine whether differences in the expression of specific genes could differentiate HCC from benign Hürthle cell nodules by evaluating differential gene expression in Hürthy cell disease.

TL;DR: It is found that ECs provide pro-tumorigenic signals and mitigate drug responses to individual T-ALL PDXs suggesting unique crosstalk interactions and/or intrinsic tumor features and can contribute to elucidating leukemia-microenvironment interactions and identify effective compounds and therapeutic vulnerabilities.

TL;DR: Mlynarczyk et al. as mentioned in this paper found that mutations affecting BTG1 disrupt a critical immune gatekeeper mechanism that strictly limits B cell fitness during antibody affinity maturation, leading to aggressive invasive lymphomas.