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Olivier Elemento
Researcher at Cornell University
Publications - 596
Citations - 38936
Olivier Elemento is an academic researcher from Cornell University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 82, co-authored 471 publications receiving 27739 citations. Previous affiliations of Olivier Elemento include Princeton University & Max Planck Society.
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A New Big-Data Paradigm For Target Identification And Drug Discovery
Neel Madhukar,Prashant K. Khade,Linda Huang,Kaitlyn Gayvert,Giuseppe Galletti,Martin Stogniew,Joshua E. Allen,Paraskevi Giannakakou,Olivier Elemento +8 more
TL;DR: BANDIT is developed, a novel paradigm that integrates multiple data types within a Bayesian machine-learning framework to predict the targets and mechanisms for small molecules with unprecedented accuracy and versatility that can be used as a resource to accelerate drug discovery and direct the clinical application of small molecule therapeutics with improved precision.
Journal ArticleDOI
Sox17 drives functional engraftment of endothelium converted from non-vascular cells.
William Schachterle,Chaitanya R. Badwe,Brisa Palikuqi,Balvir Kunar,Michael Ginsberg,Raphael Lis,Masataka Yokoyama,Olivier Elemento,Joseph M. Scandura,Joseph M. Scandura,Shahin Rafii +10 more
TL;DR: It is shown that only amniotic cells could convert to cells that maintain EC gene expression, and these converted cells perform sub-optimally in transplantation studies.
Journal ArticleDOI
A novel prognostic two-gene signature for triple negative breast cancer.
Mansour Alsaleem,Mansour Alsaleem,Graham Ball,Michael S. Toss,Sara Raafat,Mohammed A. Aleskandarany,Chitra Joseph,Angela Ogden,Shristi Bhattarai,Padmashree C.G. Rida,Francesca Khani,Melissa Davis,Olivier Elemento,Ritu Aneja,Ian O. Ellis,Andrew R. Green,Nigel P. Mongan,Nigel P. Mongan,Emad A. Rakha,Emad A. Rakha +19 more
TL;DR: This study identifies a prognostic gene signature that can predict prognosis in T NBC patients and could potentially be used to guide the clinical management of TNBC patients.
Journal ArticleDOI
EZH2 and BCL6 Cooperate To Create The Germinal Center B-Cell Phenotype and Induce Lymphomas Through Formation and Repression Of Bivalent Chromatin Domains
Matt Teater,Katerina Hatzi,Relja Popovich,Yanwen Jiang,Karen L. Bunting,Monica Rosen,Hao Shen,Shao Ning Yang,Young Rock Chung,Rita Shaknovich,Caretha L. Creasy,Randy D. Gascoyne,Leandro Cerchietti,Ross L. Levine,Omar Abdel-Wahab,Jonathan D. Licht,Olivier Elemento,Ari Melnick +17 more
TL;DR: It is demonstrated that EZH2 mediates the GC phenotype through de novo formation of bivalently marked chromatin domains at the promoters of target genes involved in cell cycle regulation and when aberrantly active may cooperate to form GC-derived B-cell lymphomas.