Olivier Elemento

TL;DR: This collective effort to track and share information will be invaluable in predicting hotspots of disease outbreak, identifying which factors control the rate of spreading, informing immediate policy decisions, evaluating the effectiveness of measures taken by health organizations on pandemic control, and providing critical insight on the etiology of COVID-19.

TL;DR: It is shown that UC patients harbor a high prevalence of putative deleterious germline variants that truncate tumor suppressor proteins, suggesting a critical role for these pGVs in tumor progression.

TL;DR: UCHL1 loss correlates with metastatic potential in PNETs and its re-expression induces a less aggressive phenotype in vitro, in part by inducing cell-cycle arrest through post-translational regulation of phosphorylated CHK2.

TL;DR: STMN1 is overexpressed in human ACC samples, and knockdown of this target in vitro resulted in a less aggressive phenotype of ACC, particularly under serum-starved conditions, and the feasibility of interfering with STMN1 as a potential therapeutic target is investigated.

TL;DR: It is demonstrated that reduced SIRT1 levels are associated with elevated levels of acetyl–HIF-1α, HIF- 1α, and aromatase in breast tissue of obese women compared with lean women.