Olivier Elemento

TL;DR: Small-molecule inhibitors that display higher affinity for BCL6 than its endogenous corepressor ligands are designed to evaluate their therapeutic efficacy for targeting ABC-DLBCL and indicate that ABC- DLBCL is a BCL 6-dependent disease that can be targeted by rationally designed inhibitors that exceed the binding affinity of natural BCL7 ligands.

TL;DR: A mutation encoding a truncated form of the pannexin-1 (PANX1) channel, PANX11–89, is identified as recurrently enriched in highly metastatic breast cancer cells, suggesting a molecular basis for metastatic cell survival on microvasculature-induced biomechanical trauma.

TL;DR: It is shown that, in pluripotent stem cells, certain histone marks and stem cell regulators remain associated with specific genomic regions of mitotic chromatin, a phenomenon known as mitotic bookmarking.

TL;DR: Implementing patient-specific computational and mathematical models of cancer will significantly improve the specificity and efficacy of targeted therapy, and will accelerate the adoption of personalized and precision cancer medicine.

TL;DR: An individual presenting with typical FA features who is deficient for the ubiquitin-conjugating enzyme (E2), UBE2T is described, demonstrating that deficiency of the protein UBE1T can lead to Fanconi anemia.