Olivier Elemento

TL;DR: The early findings of the impact of next-generation sequencing on cancer patient outcomes are discussed and increased transparency around the determination of “actionable mutations” and a heightened focus on investigating the variations in health insurance coverage across patients receiving sequencing-matched therapies are recommended.

TL;DR: H3.3 is a crucial maternal factor for oocyte reprogramming and provides a practical model to directly dissect the oocyte for its reprograming capacity, and can be rescued by injecting exogenous H3.2 mRNA into oocytes in SCNT embryos.

TL;DR: This study provides direct evidence that endogenous Rspo2 and RSPo3 chromosome rearrangements can initiate and maintain tumour development, and indicates a viable therapeutic window for LGK974 treatment of RSPO-fusion cancers.

TL;DR: In this paper, the authors used PfAP2-G, the master regulator of sexual conversion, as a marker of commitment in the early stages of the malaria life cycle and found that sexual conversion can occur by two different routes: the previously described route in which PfAP-G-expressing parasites complete a replicative cycle as committed forms before converting into gametocytes upon re-invasion, or a direct route with conversion within the same cycle as initial PfAP 2-G expression.

TL;DR: It is shown that Aid-null cells are transiently hyper-responsive to the reprogramming process, and hypermethylated genes associated with pluripotency fail to be stably upregulated, including many MYC target genes.