Olivier Elemento

TL;DR: Overexpression of MMSET can also induce gene repression by imposing EZH2 and H3K27me3 accumulation at specific genomic loci, and is validated as a therapeutic target by using KMS11 t(4;14)+ cells that express MMSet specific shRNA in the presence of doxycycline.

TL;DR: In this article , the authors developed a method to identify and quantify microanatomical tissue structures in multiplexed images without human intervention, which combines information on cellular phenotypes with the physical proximity of cells to accurately identify organ-specific microANATomical domains in healthy and diseased tissue.

TL;DR: The DepMap project is examined, and a lack of correlation between CRISPR and shRNA LoF results is found, and ECLIPSE, a machine learning approach, which combines genomic, cell line, and experimental design features to predict essential genes and platform specific essential genes in specific cancer cell lines is introduced.

TL;DR: In this article, a microtubule (MT) plus-end-binding CLIP-170 protein variant was found enriched in taxane-resistant cell lines and patient samples, and Imatinib treatment selectively depleted CLIP170S, thus completely reversing taxane resistance.

TL;DR: A curated scRNA-seq dataset of human muscle samples from 10 adult donors with diverse anatomical locations provides a new technical resource to examine human muscle tissue heterogeneity and identify potential targets in MuSC diversity and dysregulation in disease contexts.