Olivier Elemento

TL;DR: A robust precision cancer care platform that integrates whole-exome sequencing with a living biobank that enables high-throughput drug screens on patient-derived tumor organoids is described, which promotes the discovery of novel therapeutic approaches that can be assessed in clinical trials and provides personalized therapeutic options where standard clinical options have been exhausted.

TL;DR: Nuclear enriched abundant transcript 1 (NEAT1) is identified as the most significantly overexpressed lncRNA in prostate cancer and evidence that NEAT1 drives oncogenic growth by altering the epigenetic landscape of target gene promoters to favour transcription is provided.

TL;DR: It is shown that clusters of transcription factors, angiocrine growth factors, adhesion molecules, and chemokines are expressed in unique combinations by ECs of each organ.

TL;DR: It is demonstrated that inactivation of the Fto gene, encoding a nucleic acid demethylase, impairs dopamine receptor type 2 (D2R) and type 3 (D3R) (collectively, 'D2-like receptor')-dependent control of neuronal activity and behavioral responses.

TL;DR: Dan Robinson, Eliezer M. Robinson, Andrea Sboner, Marc Schiffman, David M. Smith, Christine Brennan, Javed Siddiqui, Rohit Mehra, Yu Chen, Dana E. Rathkopf, Michael J. Morris, Stephen B. Solomon, Jeremy C. Tomlins, Kathleen A. Reuter, Anuradha Gopalan, Jianjiong Gao, Massimo Loda, Rosina T.