Olivier Elemento

TL;DR: It is argued that systems-level approaches are needed to help understand the concerted impact of tumor-specific and immune-specific molecular features on clinical outcomes, predict responders and unravel the complexity of tumor ecosystems.

TL;DR: This work shows that the expression profile for at least one third of zygotically active genes is coupled to the concomitant degradation of the corresponding maternal mRNAs, and proposes that this regulatory mode links morphogen gradients with temporal regulation during the maternal-to-zygotic transition.

TL;DR: In this paper , the authors used commercially available cell lines for the identification of novel drugs for the treatment of bladder cancer and confirmed the effects of one of these drugs, clofarabine, in patient derived cell lines and two different mouse models, thereby demonstrating the potential clinical relevance of this substance in bladder cancer treatment.

TL;DR: In this article, a hierarchical map of myogenic cell populations and identifying stage-specific regulatory programs that govern their contributions to muscle regeneration is provided. But, a unified organization of muscle stem and progenitor cells and their subpopulations remains unresolved.

TL;DR: In this article , the mutagenic signatures attributed to APOBEC3 cytidine deaminases are pervasive in human cancers and the authors showed that transgenic expression of human APEC3G promotes mutagenesis, genomic instability, and kataegis, leading to shorter survival in a murine bladder cancer model.