O
Olivier Elemento
Researcher at Cornell University
Publications - 596
Citations - 38936
Olivier Elemento is an academic researcher from Cornell University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 82, co-authored 471 publications receiving 27739 citations. Previous affiliations of Olivier Elemento include Princeton University & Max Planck Society.
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Journal ArticleDOI
Prostate-Specific Membrane Antigen Is a Potential Antiangiogenic Target in Adrenocortical Carcinoma
Michael J. Crowley,Theresa Scognamiglio,Yifang Liu,David A. Kleiman,Toni Beninato,Anna Aronova,He Liu,Yuliya Jhanwar,Ana M. Molina,Scott T. Tagawa,Neil H. Bander,Rasa Zarnegar,Olivier Elemento,Olivier Elemento,Thomas J. Fahey +14 more
TL;DR: PSMA expression can be used to image ACC metastases in vivo and may be considered as a potential diagnostic and therapeutic target in ACC.
Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer
Hui Liu,Charles J. Murphy,Florian A. Karreth,Kristina B. Emdal,Forest M. White,Olivier Elemento,Alex Toker,Gerburg M. Wulf,Lewis C. Cantley +8 more
TL;DR: The study suggests that the combination of WES and RNA-seq on human TNBC will lead to the identification of actionable therapeutic targets for precision medicine-guided TNBC treatment and demonstrates that approved or experimental drugs efficiently induce tumor regression specifically in tumors harboring somatic aberrations of the drug target.
Journal ArticleDOI
The ERβ4 variant induces transformation of the normal breast mammary epithelial cell line MCF-10A; the ERβ variants ERβ2 and ERβ5 increase aggressiveness of TNBC by regulation of hypoxic signaling
Michelle Faria,Samaneh Karami,Sergio Granados-Principal,Prasenjit Dey,Akanksha Verma,Dong S. Choi,Olivier Elemento,Tasneem Bawa-Khalfe,Jenny C. Chang,Anders Ström,Jan-Åke Gustafsson,Jan-Åke Gustafsson +11 more
TL;DR: It is proposed that ERβ variants may be good diagnostic tools and also serve as novel targets for treatment of breast cancer.
Posted ContentDOI
Novel patterns of complex structural variation revealed across thousands of cancer genome graphs
Kevin Hadi,Xiaotong Yao,Julie M. Behr,Aditya Deshpande,Xanthopoulakis C,Joel Rosiene,Darmofal M,Huasong Tian,DeRose J,Mortensen R,Emily M. Adney,Zoran Gajic,Kenneth Eng,Jeremiah Wala,Jeremiah Wala,Jeremiah Wala,Kazimierz O. Wrzeszczynski,Kanika Arora,Minita Shah,Anne-Katrin Emde,Felice,Mayu O. Frank,Robert B. Darnell,Mahmoud Ghandi,Franklin W. Huang,Franklin W. Huang,John Maciejowski,de Lange T,Jeremy Setton,Nadeem Riaz,Jorge S. Reis-Filho,Simon N. Powell,David A. Knowles,Ed Reznik,Bud Mishra,Rameen Beroukhim,Rameen Beroukhim,Michael C. Zody,Nicolas Robine,Kenji Oman,Carissa A. Sanchez,Kuhner Mk,Smith Lp,Patricia C. Galipeau,Thomas G. Paulson,Brian J. Reid,Xiaohong Li,David Wilkes,Andrea Sboner,Juan Miguel Mosquera,Olivier Elemento,Marcin Imielinski +51 more
TL;DR: Clustering of tumors according to genome graph-derived features identifies subgroups associated with DNA repair defects and poor prognosis using a novel genome graph computational paradigm.