Olivier Elemento

TL;DR: It is found in SSCs that promoters essential to maintenance and differentiation of embryonic stem cells (ESCs) are enriched with histone H3-lysine4 and -lysine 27 trimethylations, and that both conversion of promoter chromatin states and activation of cell type-specific enhancers are prominent features of reprogramming.

TL;DR: This study provides the first comprehensive characterization of aberrations in DNA methylation in relapse DLBCLs and suggests that methylation changes associated with lymphomagenesis might frequently involve one allele only, perhaps due to differential nuclear localization of individual chromosomes.

TL;DR: In this article, the synergy between Rb1 loss and MYCN (encodes N-Myc) overexpression was characterized for the formation of AR-negative, poorly differentiated tumors with high metastatic potential.

TL;DR: It is found that INPP4B deficiency increases PI(3,4)P2 levels in endocytic vesicles but not at the plasma membrane, thus enhancing the duration and amplitude of signaling output upon growth factor stimulation, and promotes tumorigenesis by modulating RTK recycling and signaling duration.

TL;DR: A novel transgene is applied to label and manipulate neural stem/progenitor cells, and monitor their evolution during aging to analyze the subventricular zone (SVZ) cells from infancy to advanced age with unprecedented granularity.