Olivier Elemento

TL;DR: MethSig as discussed by the authors provides a novel statistical framework for the analysis of DNA methylation changes in cancer, to specifically identify candidate DNAmethylation driver genes of cancer progression and relapse, empowering the discovery of epigenetic mechanisms that enhance cancer cell fitness.

TL;DR: It is hypothesized that the corresponding gene, ERBB2, is affected by mutations in a subset of UBC and that these mutations impact ErbB2 function, signaling, UBC proliferation, gene expression, and predict response to lapatinib.

TL;DR: In this paper, the ability to differentiate human pluripotent stem cells into endothelial cells with properties of cord-blood endothelial colony-forming cells (CB-ECFCs) may enable the derivation of clinically relevant numbers of highly proliferative blood vessel forming cells to restore endothelial function in patients with vascular disease.

TL;DR: It is shown by ChIP-seq experiments that the chromatin remodeler CHD8 mostly binds promoters under proliferation conditions, however, upon progestin stimulation,CHD8 re-localizes to PR enhancers also enriched in p300 and H3K4me1.