O
Orr Ashenberg
Researcher at Broad Institute
Publications - 61
Citations - 6645
Orr Ashenberg is an academic researcher from Broad Institute. The author has contributed to research in topics: Biology & Immune system. The author has an hindex of 28, co-authored 48 publications receiving 3568 citations. Previous affiliations of Orr Ashenberg include Massachusetts Institute of Technology & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
Livnat Jerby-Arnon,Parin Shah,Michael S. Cuoco,Christopher Rodman,Mei-Ju Su,Johannes C. Melms,Rachel Leeson,Abhay Kanodia,Shaolin Mei,Jia-Ren Lin,Shu Wang,Bokang Rabasha,David Liu,Gao Zhang,Claire Margolais,Orr Ashenberg,Patrick A. Ott,Elizabeth I. Buchbinder,Rizwan Haq,F. Stephen Hodi,Genevieve M. Boland,Ryan J. Sullivan,Dennie T. Frederick,Benchun Miao,Tabea Moll,Keith T. Flaherty,Meenhard Herlyn,Russell W. Jenkins,Rohit Thummalapalli,Monika S. Kowalczyk,Israel Cañadas,Bastian Schilling,Bastian Schilling,Adam N.R. Cartwright,Adrienne M. Luoma,Shruti Malu,Patrick Hwu,Chantale Bernatchez,Marie Andrée Forget,David A. Barbie,Alex K. Shalek,Itay Tirosh,Peter K. Sorger,Kai W. Wucherpfennig,Eliezer M. Van Allen,Dirk Schadendorf,Bruce E. Johnson,Asaf Rotem,Asaf Rotem,Orit Rozenblatt-Rosen,Levi A. Garraway,Charles H. Yoon,Charles H. Yoon,Benjamin Izar,Aviv Regev +54 more
TL;DR: A resistance program expressed by malignant cells that is associated with T cell exclusion and immune evasion is identified, and this study provides a high-resolution landscape of ICI-resistant cell states, identifies clinically predictive signatures, and suggests new therapeutic strategies to overcome immunotherapy resistance.
Journal ArticleDOI
A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia
Ninib Baryawno,Dariusz Przybylski,Monika S. Kowalczyk,Youmna Kfoury,Nicolas Severe,Karin Gustafsson,Konstantinos D. Kokkaliaris,Francois Mercier,Marcin Tabaka,Matan Hofree,Danielle Dionne,Ani Papazian,Dongjun Lee,Orr Ashenberg,Ayshwarya Subramanian,Eeshit Dhaval Vaishnav,Orit Rozenblatt-Rosen,Aviv Regev,Aviv Regev,David T. Scadden +19 more
TL;DR: The data suggest that tissue stroma responds to malignant cells by disadvantaging normal parenchymal cells, and provides a comprehensive bone marrow cell census and experimental support for cancer cell crosstalk with specific stromal elements to impair normal tissue function and thereby enable emergent cancer.
Journal ArticleDOI
Rewiring the Specificity of Two-Component Signal Transduction Systems
Jeffrey M. Skerker,Barrett S. Perchuk,Albert Siryaporn,Emma A. Lubin,Orr Ashenberg,Mark Goulian,Michael T. Laub +6 more
TL;DR: The results shed light on the basis of molecular discrimination in two-component signaling pathways, provide a general approach for the rational rewiring of these pathways, and suggest that analyses of coevolution may facilitate the reprogramming of other signaling systems and protein-protein interactions.
Journal ArticleDOI
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.
Toni Delorey,Carly G. K. Ziegler,Graham Heimberg,Rachelly Normand,Yiming Yang,Yiming Yang,Asa Segerstolpe,Domenic Abbondanza,Stephen J. Fleming,Ayshwarya Subramanian,Daniel T. Montoro,Karthik A. Jagadeesh,Kushal K. Dey,Pritha Sen,Michal Slyper,Yered Pita-Juárez,Devan Phillips,Jana Biermann,Zohar Bloom-Ackermann,Nikolaos Barkas,Andrea Ganna,Andrea Ganna,James Gomez,Johannes C. Melms,Igor Katsyv,Erica Normandin,Erica Normandin,Pourya Naderi,Pourya Naderi,Yury Popov,Yury Popov,Siddharth S. Raju,Siddharth S. Raju,Sebastian Niezen,Sebastian Niezen,Linus T.-Y. Tsai,Katherine J. Siddle,Katherine J. Siddle,Malika Sud,Victoria M. Tran,Shamsudheen K. Vellarikkal,Shamsudheen K. Vellarikkal,Yiping Wang,Liat Amir-Zilberstein,Deepak Atri,Deepak Atri,Joseph M. Beechem,Olga R. Brook,Jonathan H. Chen,Jonathan H. Chen,Prajan Divakar,Phylicia Dorceus,Jesse M. Engreitz,Jesse M. Engreitz,Adam Essene,Donna M. Fitzgerald,Robin Fropf,Steven Gazal,Joshua Gould,John Grzyb,Tyler Harvey,Jonathan L. Hecht,Jonathan L. Hecht,Tyler Hether,Judit Jané-Valbuena,Michael Leney-Greene,Hui Ma,Hui Ma,Cristin McCabe,Daniel E. McLoughlin,Eric M. Miller,Christoph Muus,Christoph Muus,Mari Niemi,Robert F. Padera,Robert F. Padera,Robert F. Padera,Liuliu Pan,Deepti Pant,Carmel Pe’er,Jenna Pfiffner-Borges,Christopher J. Pinto,Jacob Plaisted,Jason Reeves,Marty Ross,Melissa Rudy,Erroll H. Rueckert,Michelle Siciliano,Alexander Sturm,Ellen Todres,Avinash Waghray,Sarah Warren,Shuting Zhang,Daniel R. Zollinger,Lisa A. Cosimi,Rajat M. Gupta,Rajat M. Gupta,Nir Hacohen,Nir Hacohen,Hanina Hibshoosh,Winston Hide,Alkes L. Price,Jayaraj Rajagopal,Purushothama Rao Tata,Stefan Riedel,Stefan Riedel,Gyongyi Szabo,Gyongyi Szabo,Gyongyi Szabo,Timothy L. Tickle,Patrick T. Ellinor,Deborah T. Hung,Deborah T. Hung,Pardis C. Sabeti,Richard M. Novak,Robert S. Rogers,Robert S. Rogers,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber,Z. Gordon Jiang,Z. Gordon Jiang,Dejan Juric,Mehrtash Babadi,Samouil L. Farhi,Benjamin Izar,James R. Stone,Ioannis S. Vlachos,Isaac H. Solomon,Orr Ashenberg,Caroline B. M. Porter,Bo Li,Bo Li,Alex K. Shalek,Alexandra-Chloé Villani,Orit Rozenblatt-Rosen,Orit Rozenblatt-Rosen,Aviv Regev +137 more
TL;DR: In this article, single-cell analysis of lung, heart, kidney and liver autopsy samples shows the molecular and cellular changes and immune response resulting from severe SARS-CoV-2 infection.
Journal ArticleDOI
Decoding human fetal liver haematopoiesis
Dorin-Mirel Popescu,Rachel A. Botting,Emily Stephenson,Kile Green,Simone Webb,Laura Jardine,Emily Calderbank,Krzysztof Polanski,Issac Goh,Mirjana Efremova,Meghan Acres,Daniel Maunder,Peter Vegh,Yorick Gitton,Jong-Eun Park,Roser Vento-Tormo,Zhichao Miao,Zhichao Miao,David Dixon,Rachel Rowell,David McDonald,James Fletcher,Elizabeth Poyner,Gary Reynolds,Michael W. Mather,Corina Moldovan,Lira Mamanova,Frankie Greig,Matthew D. Young,Kerstin B. Meyer,Steven Lisgo,Jaume Bacardit,Andrew Fuller,Ben Millar,Barbara A. Innes,Susan Lindsay,Michael J. T. Stubbington,Monika S. Kowalczyk,Bo Li,Orr Ashenberg,Marcin Tabaka,Danielle Dionne,Timothy L. Tickle,Timothy L. Tickle,Michal Slyper,Orit Rozenblatt-Rosen,Andrew Filby,Peter D. Carey,Alexandra-Chloé Villani,Alexandra-Chloé Villani,Anindita Roy,Aviv Regev,Aviv Regev,Alain Chédotal,Irene Roberts,Berthold Göttgens,Sam Behjati,Sam Behjati,Elisa Laurenti,Sarah A. Teichmann,Sarah A. Teichmann,Muzlifah Haniffa,Muzlifah Haniffa +62 more
TL;DR: A shift in the haemopoietic composition of fetal liver during gestation away from being predominantly erythroid, accompanied by a parallel change in differentiation potential of HSC/MPPs is demonstrated, which is validated to produce an integrated map of fetal liver haematopoiesis.