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Lawrence W. Brown

Researcher at Children's Hospital of Philadelphia

Publications -  38
Citations -  1466

Lawrence W. Brown is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Tourette syndrome & Genome-wide association study. The author has an hindex of 12, co-authored 36 publications receiving 981 citations. Previous affiliations of Lawrence W. Brown include Hospital of the University of Pennsylvania & University of Pennsylvania.

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Journal ArticleDOI

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Phil Lee, +606 more
- 12 Dec 2019 - 
TL;DR: Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes.
Journal Article

NREM sleep instability is reduced in children with attention-deficit/hyperactivity disorder. Commentary

TL;DR: In this article, the authors evaluated non-rapid eye movement sleep instability (NREM), as measured by the cyclic alternating pattern (CAP), in a cohort of children with attention-deficit/hyperactivity disorder (ADHD) and normal controls.
Journal ArticleDOI

Periodic limb movement in sleep in children with Williams syndrome

TL;DR: An association between Williams syndrome and PLMS is reported and clonazepam may reduce the clinical symptoms of PLMS in some of these children.
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Potentiation of neuromuscular weakness in infant botulism by aminoglycosides.

TL;DR: A retrospective study of ten patients with infant botulism who received gentamicin or kanamycin suggests that aminoglycoside antibiotics potentiate muscular weakness and precipitate respiratory failure as late as 27 days after onset of the disease.