Matteo Cassina

TL;DR: Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes.

TL;DR: The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index.

TL;DR: In this paper, the authors examined the association of both drugs with congenital malformations using data from the International Clearinghouse for Birth Defects Surveillance and Research (ICSBRS).

TL;DR: There is currently no evidence that metformin is associated with an increased risk of major birth defects in women affected by PCOS and treated during the first trimester, but larger ad hoc studies are warranted in order to definitely confirm the safety and efficacy of this drug in pregnancy.