Véronique Golfier

TL;DR: TARDBP mutations are described in two patients with FTLD‐MND, presenting with a behavioral variant of FTLD and semantic dementia, suggesting that TDP‐43 may also have a direct pathogenic role in FTLD disorders.

TL;DR: The findings suggest that immune system processes (link to 6p21.3) and possibly lysosomal and autophagy pathways ( link to 11q14) are potentially involved in FTD.

TL;DR: This study shows that fvFTD is clinically a rather homogeneous entity and provides evidence that different behavioural presentations at onset are related to different anatomical localizations of degenerative damage, and demonstrates the prognostic value of brainstem hypoperfusion in a subgroup of patients with a short survival.

TL;DR: It is supported that PGRN null mutations represent a more frequent cause of FTD than MAPT mutations but are not responsible for FTD‐MND, and genetic testing should be considered more systematically, even in patients without obvious familial history ofFTD.

TL;DR: This study increases the number of 9p-linked families now reported and shows that this locus may have a major effect on frontotemporal dementia (FTD) and motor neuron disease (MND).